SEARCH · PubMed Health

Results for “Thinking”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,027 records · Page 57Linked to original sources

PubMed2002

The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function.

Proper synaptic development is critical for establishing all aspects of neural function including learning, memory, and locomotion. Here, we describe the phenotypic consequences of mutations in the wishful thinking (wit) gene, the Drosophila homolog of the vertebrate BMP type II receptor. Mutations in wit result in pharate lethality that can be rescued by expression of a wit transgene in motor neurons but not in muscles. Mutant larvae exhibit small synapses, severe defects in evoked junctional potentials, a lower frequency of spontaneous vesicle release, and an alteration in the ultrastructure of synaptic active zones. These results reveal a novel role for BMP signaling in regulating Drosophila neuromuscular junction synapse assembly and activity and may indicate that similar pathways could govern vertebrate synapse development.

Animals↗

PubMed2003

Pre-frontal executive committee for perception, working memory, attention, long-term memory, motor control, and thinking: a tutorial review.

As an explicit organizing metaphor, memory aid, and conceptual framework, the prefrontal cortex may be viewed as a five-member 'Executive Committee,' as the prefrontal-control extensions of five sub-and-posterior-cortical systems: (1) the 'Perceiver' (dominant-right-hemisphere ventral-lateral prefrontal cortex--VL/PERC-PFC) is the frontal extension of the ventral perceptual stream (the VL/PERC system) which represents the world and self in object coordinates; (2) the 'Verbalizer' (dominant-left-hemisphere ventral-lateral prefrontal cortex system--VL/VERB-PFC) is the frontal extension of the language stream (the VL/VERB system) which represents the world and self in language coordinates; (3) the 'Motivator' (ventral/medial-orbital pre-frontal cortex--VMO-PFC) is the frontal cortical extension of a subcortical extended-amygdala stream (the VMO system) which represents the world and self in motivational/emotional coordinates; (4) the 'Attender' (dorsal-medial/anterior cingulate--DM/AC-PFC) is the frontal cortical extension of a subcortical extended-hippocampal stream (the DM/AC system) which represents the world and self in spatiotemporal coordinates and directs attention to internal and external events; and (5) the 'Coordinator' (the dorsolateral prefrontal cortex--DL-PFC) is the frontal extension of the dorsal perceptual stream (the DL system) which represents the world and self in body- and eye-coordinates and controls willed action and working memory. This tutorial review examines the interacting roles of these five systems in perception, working memory, attention, long-term memory, motor control, and thinking.

Attention↗

PubMed2000

Continuous self-improvement: systems thinking in a personal context.

BACKGROUND: Continuous quality improvement (CQI) thinking and tools have broad applicability to improving people's lives--in continuous self-improvement (CSI). Examples include weight loss, weight gain, increasing exercise time, and improving relationship with spouse. In addition, change agents, who support and facilitate organizational efforts, can use CSI to help employees understand steps in CQI. A STEP-BY-STEP APPROACH: Team members should be involved in both the definition of the problem and the search for the solution. How do everyday processes and routines affect the habit that needs to change? What are the precursors of the event? Clients list possible solutions, prioritize them, and pilot test the items selected. One needs to change the daily routines until the desired behavior is accomplished habitually and with little external decision. DISCUSSION: CSI is successful because of its emphasis on habits embedded in personal processes. CSI organizes support from process owners, buddies, and coaches, and encourages regular measurement, multiple small improvement cycles, and public reporting.

Activities of Daily Living↗

PubMed1994

Linking outcomes measurement to continual improvement: the serial "V" way of thinking about improving clinical care.

BACKGROUND: Outcomes measurement, process improvement, and continual improvement all have been used to improve quality in health care. However, the mutually complementary approaches have been used primarily in isolation from each other. The "Serial V" ("Vee") concept attempts to integrate these approaches to provide a fuller assessment and practical approach to quality improvement. METHODS: Outcomes measurement is used primarily to identify variations in care and possibly to determine corrective actions that may minimize those variations. Process improvement focuses on breaking down the components of a specific process of health care delivery, identifying or reworking problem areas in the process, then rebuilding the process. Continual improvement involves pinpointing a particular area for improvement, proposing specific changes, testing the instituted changes, and evaluating the success of such changes. The Serial V concept is an integrative strategy that incorporates aspects of all three approaches to create a comprehensive way to evaluate, institute, and reflect on change aimed at improvement. While this way of thinking appears complex at first glance, a practical worksheet that details each step in the process can be used to begin the clinical improvement work. Use of the Serial V approach, which unites measurement of outcomes, analysis of the clinical process, and repeated pilot tests to improve outcomes in real-world clinical settings, will accelerate improvement in health care outcomes and eliminate unnecessary costs.

Clinical Protocols↗

PubMed1995

Think globally, act locally: an approach to implementation of clinical practice guidelines.

BACKGROUND: In an environment of concern about the rising costs of medical care, the Vermont Program for Quality in Health Care (VPQHC; the program) was incorporated in 1988 as a nonprofit organization and in 1989 was made a peer review organization by the state legislature. The program acts a resource center for health care in Vermont, coordinating three functions: implementation and maintenance of a statewide database for healthcare quality; training for health care providers in continuous quality improvement (CQI) methods and support for their CQI projects; and focusing clinical study group work on specific diagnoses or procedures. METHODS: The program uses a seven-step process for implementing CQI: pick a process (modify a nationally developed guideline or develop a new guideline); select a team of people involved in doing the work; establish goals and key quality factors; document the clinical process; determine what and how to measure; measure and analyze data; and modify the process to improve. GUIDELINE: This article describes the implementation of a guideline from the American College of Obstetricians and Gynecologists (ACOG) on cesarean section (C-section). Except for a few specific contraindications, the ACOG paper states that it is reasonable to encourage vaginal birth after C-section. A related set of criteria from ACOG states that the benchmark for emergency C-section should be 30 minutes from the decision to proceed with an emergency C-section until the baby is born. CASE STUDY: State C-section rates from 1985-1990 showed wide variation by hospital. Such wide variation is based as much on practice style as on sound science. C-section rates (primary and repeated) were measured, plotted, and shared with Vermont hospitals. Successful vaginal birth after C-section (VBAC) rates from the statewide data-base also were shared. Based on these data, one hospital, Hospital A, developed a plan to lower its repeated C-section rate and improve its VBAC rate. Hospital A collected and reviewed local data, which showed interesting variations. The time from decision to birth became the focus of the overall project; Hospital A designed its project to study events during the time from decision to birth. RESULTS: Most recent data (1992-1993) from Hospital A shows improvement in three areas. First, 89% of patients having emergency C-sections met the goal of a 30-minute time frame from decision to incision. Second, the VBAC success rate for the same time period increased to 85.7% from 69% in the previous year, and from a mere 7% before the implementation of the project. Third, the percentage of total C-sections that were repeat C-sections fell to 36% from a high of 51%. In a follow-up evaluation, one-third of the C-section performed from October 1, 1993, to July 31, 1994 were performed because of patient refusal to attempt VBAC, suggesting that there is a communitywide culture that influences behavior. A major effort at patient education on VBAC is underway. CONCLUSIONS: Think globally, act locally, might be the motto for the program. Implementing guidelines starts with obtaining national guidelines and literature but needs the use of local data to sharpen the focus on narrow areas to address. Specifically, it is unrealistic to tackle the entire problem at once. Success comes from finding specific opportunities for improvement.

Cesarean Section↗

PubMed2001

Thinking about the unknown.

A long tradition of research suggests that children and adults with no formal education are prone to reason only on the basis of their first-hand experience, and do not encode and reason from novel generalizations supplied by other people. However, recent research reveals that when given simple prompts, even pre-school children can reason from adults' unfamiliar claims. A radical implication of these findings is that young children arrive at school with a pre-existing capacity for thinking and reasoning about the unknown. The assumption that early learning should be rooted in children's own empirical experience could be mistaken.

Journal Article↗

PubMed2003

Behavioural studies of strategic thinking in games.

Game theory is a mathematical language for describing strategic interactions, in which each player's choice affects the payoff of other players (where players can be genes, people, companies, nation-states, etc.). The impact of game theory in psychology has been limited by the lack of cognitive mechanisms underlying game-theoretic predictions. 'Behavioural game theory' is a recent approach linking game theory to cognitive science by adding cognitive details about 'social utility functions', theories of limits on iterated thinking, and statistical theories of how players learn and influence others. New directions include the effects of game descriptions on choice ('framing'), strategic heuristics, and mental representation. These ideas will help root game theory more deeply in cognitive science and extend the scope of both enterprises.

Journal Article↗

PubMed1999

The role of gesture in communication and thinking.

People move their hands as they talk - they gesture. Gesturing is a robust phenomenon, found across cultures, ages, and tasks. Gesture is even found in individuals blind from birth. But what purpose, if any, does gesture serve? In this review, I begin by examining gesture when it stands on its own, substituting for speech and clearly serving a communicative function. When called upon to carry the full burden of communication, gesture assumes a language-like form, with structure at word and sentence levels. However, when produced along with speech, gesture assumes a different form - it becomes imagistic and analog. Despite its form, the gesture that accompanies speech also communicates. Trained coders can glean substantive information from gesture - information that is not always identical to that gleaned from speech. Gesture can thus serve as a research tool, shedding light on speakers' unspoken thoughts. The controversial question is whether gesture conveys information to listeners not trained to read them. Do spontaneous gestures communicate to ordinary listeners? Or might they be produced only for speakers themselves? I suggest these are not mutually exclusive functions - gesture serves as both a tool for communication for listeners, and a tool for thinking for speakers.

Journal Article↗

PubMed2002

Persons and their bodies: how we should think about human embryos.

The status of human embryos is discussed particularly in the light of the claim by Fox, in Health Care Analysis 8 that it would be useful to think of them in terms of cyborg metaphors. It is argued that we should consider human embryos for what they are--partially formed human bodies--rather than for what they are like in some respects (and unlike in others)--cyborgs. However to settle the issue of the status of the embryo is not to answer the moral questions which arise concerning how embryos should be treated. Since persons rather than bodies have rights, embryos do not have rights. However, whether or not embryos have rights, people can have duties concerning them. Furthermore, the persons whose fully developed bodies embryos will, might (or might have) become can have rights. Contrary to what is often assumed, it is not merely persons who have (or have had) living, developed human bodies who have moral rights: so it is argued in this paper.

Embryo, Mammalian↗

PubMed2003

Examining the role of implementation quality in school-based prevention using the PATHS curriculum. Promoting Alternative THinking Skills Curriculum.

In order for empirically validated school-based prevention programs to "go to scale," it is important to understand the processes underlying program dissemination. Data collected in effectiveness trials, especially those measuring the quality of program implementation and administrative support, are valuable in explicating important factors influencing implementation. This study describes findings regarding quality of implementation in a recent effectiveness trial conducted in a high-risk, American urban community. This delinquency prevention trial is a locally owned intervention, which used the Promoting Alternative THinking Skills Curriculum as its major program component. The intervention involved 350 first graders in 6 inner-city public schools. Three schools implemented the intervention and the other 3 were comparison schools from the same school district. Although intervention effects were not found for all the intervention schools, the intervention was effective in improving children's emotional competence and reducing their aggression in schools which effectively supported the intervention. This study, utilizing data from the 3 intervention schools (13 classrooms and 164 students), suggested that 2 factors contributed to the success of the intervention: (a) adequate support from school principals and (b) high degree of classroom implementation by teachers. These findings are discussed in light of the theory-driven models in program evaluation that emphasized the importance of the multiple factors influencing the implementation of school-based interventions.

Child↗

PubMed2001

Exfoliation (pseudoexfoliation) syndrome: toward a new understanding. Proceedings of the First International Think Tank.

Exfoliation (pseudoexfoliation; PEX) syndrome is the single most common identifiable cause of open-angle glaucoma, however, very few investigators are engaged in basic research on this disease. To stimulate the field, the First International Think Tank on Exfoliation Syndrome was held in New York in July 1999, comprising clinicians and scientists. This report is a summary of the proceedings of this meeting.

Exfoliation Syndrome↗

PubMed1999

Stereotypes and terror management: evidence that mortality salience enhances stereotypic thinking and preferences.

If stereotypes function to protect people against death-related concerns, then mortality salience should increase stereotypic thinking and preferences for stereotype-confirming individuals. Study 1 demonstrated that mortality salience increased stereotyping of Germans. In Study 2, it increased participants' tendency to generate more explanations for stereotype-inconsistent than stereotype-consistent gender role behavior. In Study 3, mortality salience increased participants' liking for a stereotype-consistent African American and decreased their liking for a stereotype-inconsistent African American; control participants exhibited the opposite preference. Study 4 replicated this pattern with evaluations of stereotype-confirming or stereotype-disconfirming men and women. Study 5 showed that, among participants high in need for closure, mortality salience led to decreased liking for a stereotype-inconsistent gay man.

Adult↗

PubMed1996

The separability of working memory resources for spatial thinking and language processing: an individual differences approach.

The current study demonstrates the separability of spatial and verbal working memory resources among college students. In Experiment 1, we developed a spatial span task that taxes both the processing and storage components of spatial working memory. This measure correlates with spatial ability (spatial visualization) measures, but not with verbal ability measures. In contrast, the reading span test, a common test of verbal working memory, correlates with verbal ability measures, but not with spatial ability measures. Experiment 2, which uses an interference paradigm to cross the processing and storage demands of span tasks, replicates this dissociation and further demonstrates that both the processing and storage components of working memory tasks are important for predicting performance on spatial thinking and language processing tasks.

Adult↗

PubMed1995

Magical thinking about illness virulence: conceptions of germs from "safe" versus "dangerous" others.

AIDS-related research has documented overreactions to casual contact and underreactions to sexual risk. This contradiction is explained by "magical contagion", a principle of thinking common in traditional societies, wherein contagion is considered socially discriminating, such that harmfulness depends on the nature of the relationship between source and recipient. In Study 1, 100 undergraduate participants drew germs described as their own, a stranger's, their lover's, or a disliked peer's. Lovers' germs were depicted as less threatening than disliked peers' germs. In Study 2, scenarios described contact with a flu-infected lover, stranger, or disliked peer. New undergraduate participants (N = 133) rated how likely they were to become ill and how severely. Although likelihood ratings did not differ, severity ratings followed a linear trend, effects of lover contact being least severe and contact with disliked peer most severe. Behavioral implications of the blurring of feelings about germ source with estimates of germ virulence are discussed.

Acquired Immunodeficiency Syndrome↗

PubMed2005

Thinking quantitatively about transcriptional regulation.

By thinking about the chemical and physical mechanisms that are involved in the stepwise elongation of RNA transcripts, we can begin to understand the way that these mechanisms are controlled within the cell to reflect the different requirements for transcription that are posed by various metabolic, developmental and disease states. Here, we focus on the mechanistic details of the single-nucleotide addition (or excision) cycle in the transcription process, as this is the level at which many regulatory mechanisms function and can be explained in quantitative terms.

DNA Helicases↗

PubMed2001

Implications of organizational learning for nursing managers from the cultural, interpersonal and systems thinking perspectives.

This paper discusses the implications of organizational learning to healthcare administrators, in particular nursing managers, from the cultural, interpersonal and systems thinking perspectives. In the various perspectives the reasons for organizational ineffectiveness and remedies are presented. There is little doubt that pressure for nurses to perform is escalating as healthcare institutions attempt to improve the quality of service through restructuring and change, which leads to greater job dissatisfaction, higher turnover, lower morale and increased industrial actions of nurses. An integrated approach to organizational learning is arguably important for the effective management of nurses during periods of transition.

Humans↗

PubMed1995

Critical thinking and intuitive nursing practice.

In this paper, we analyse how critical thinking and intuitive practice are related to expertise in nursing. We examine how intuitive practice, when performed automatically without care, vigilance, and criticism, can result in prejudice and patterns of practice which are misinformed. We will show that the student nurse develops intuitive, skillful performance in nursing by reasoning about nursing knowledge and applying reflective, critical thought in practice situations, thereby gaining increasing expertise in reasoning as a reliable professional ensuring quality client care. The elements of thought necessary for sound reasoning in clinical practice will be explored. Finally, we suggest educational strategies and tactics which promote the development of the intellectual capacities of student nurses as independent critical thinkers.

Clinical Competence↗

PubMed1996

Intuition and rational decision-making in professional thinking: a false dichotomy?

A number of researchers have sought to understand what enables the 'expert' professional to achieve a rapid and effortless understanding of presenting situations. Central to many of the explanations offered is the term 'intuition'. It might be thought, therefore, that the word describes a coherent concept embracing certain related features and used with consistency. A study of the literature suggests that this is not so. 'Intuition' is more than a contested concept, it is also used in ways that lack both clarity and coherence. Some of the confusion associated with the concept seems to stem from the belief that intuition is an irrational process. As a consequence, it is assumed that intuition can be neither fully understood nor explained. In this paper we discuss a number of issues relating to the nature of 'intuition'. We argue that intuition may be understood as an irrational process that has a rational basis. Intuitive thinking has certain essential features and involves the use of a sound, rational, relevant knowledge base in situations that, through experience, are so familiar that the person has learned how to recognize and act on appropriate patterns.

Awareness↗