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PubMed1990

Lung function 8-18 years after intermittent positive pressure ventilation for hyaline membrane disease.

Lung function and respiratory symptoms were studied in 40 children aged 8-18 years who had been ventilated for hyaline membrane disease after birth; 11 had had bronchopulmonary dysplasia. Also studied were 38 age matched children who had had hyaline membrane disease but had not required ventilation, 25 unmatched children who were born prematurely but did not develop hyaline membrane disease, and 39 randomly selected pupils of similar age. There was no difference in thoracic gas volume, total lung capacity, inspiratory vital capacity, residual volume, or transfer factor for carbon monoxide between the groups. Respiratory symptoms during the three years before the study and the frequency of clinically diagnosed asthma in patients and their family were similar in all the children with hyaline membrane disease irrespective of whether they had been ventilated or had had bronchopulmonary dysplasia. The children with bronchopulmonary dysplasia, however, had a lower forced expiratory volume in one second (FEV1) before bronchodilator (73% predicted) than the other groups (88-95% predicted). Children who had required ventilation had lower values for specific airways conductance (sGaw) and a greater increase in FEV1 (delta FEV1) after salbutamol (13%) than non-ventilated children (6%); delta FEV1 was associated with the peak pressure of intermittent positive pressure ventilation, a family history of asthma and a history of wheezing, recurrent respiratory illnesses, and a doctor's diagnosis of asthma during the three years before the study. These findings indicate that after eight years of age patients with bronchopulmonary dysplasia have more reversible airways obstruction, compatible with increased bronchial smooth muscle tone.

Adolescent↗

PubMed1987

Control of ventilation in elite synchronized swimmers.

Synchronized swimmers perform strenuous underwater exercise during prolonged breath holds. To investigate the role of the control of ventilation and lung volumes in these athletes, we studied the 10 members of the National Synchronized Swim Team including an olympic gold medalist and 10 age-matched controls. We evaluated static pulmonary function, hypoxic and hypercapnic ventilatory drives, and normoxic and hyperoxic breath holding. Synchronized swimmers had an increased total lung capacity and vital capacity compared with controls (P less than 0.005). The hypoxic ventilatory response (expressed as the hyperbolic shape parameter A) was lower in the synchronized swimmers than controls with a mean value of 29.2 +/- 2.6 (SE) and 65.6 +/- 7.1, respectively (P less than 0.001). The hypercapnic ventilatory response [expressed as S, minute ventilation (1/min)/alveolar CO2 partial pressure (Torr)] was no different between synchronized swimmers and controls. Breath-hold duration during normoxia was greater in the synchronized swimmers, with a mean value of 108.6 +/- 4.8 (SE) vs. 68.03 +/- 8.1 s in the controls (P less than 0.001). No difference was seen in hyperoxic breath-hold times between groups. During breath holding synchronized swimmers demonstrated marked apneic bradycardia expressed as either absolute or heart rate change from basal heart rate as opposed to the controls, in whom heart rate increased during breath holds. Therefore the results show that elite synchronized swimmers have increased lung volumes, blunted hypoxic ventilatory responses, and a marked apneic bradycardia that may provide physiological characteristics that offer a competitive advantage for championship performance.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed2003

Keratinocyte growth factor transiently alters pulmonary function in rats.

Keratinocyte growth factor (KGF) is a mitogen for pulmonary epithelial cells. Intratracheal administration of KGF to adult rats results in alveolar epithelial type II and bronchiolar epithelial cell proliferation. While cellular responses to KGF have been intensively studied, functional consequences regarding lung function are unknown. Therefore, in this study, we sought to investigate whether KGF alters pulmonary function variables. Rats received either recombinant human KGF (rHuKGF) (5 mg/kg) or vehicle intratracheally. Before and on days 3 and 7 after treatment, pulmonary function was determined by body plethysmography. Subsequently, lung histological changes were quantified. rHuKGF induced a transient proliferation of alveolar and bronchiolar epithelial cells. The extent of type II cell hyperplasia was significantly correlated with a transient reduction in tidal volume and an increase in breathing frequency. In addition, quasi-static compliance, total lung capacity, and vital capacity were reduced after rHuKGF instillation, suggesting the development of a transitory restrictive lung disorder. Moreover, reduced expiratory flow rates and forced expiratory volumes, as well as increased functional residual capacity after rHuKGF but not vehicle, suggest obstructive lung function changes. In conclusion, the induction of alveolar and bronchiolar epithelial cell proliferation by KGF is paralleled by moderate functional consequences that should be taken into account when the therapeutic potential of KGF is tested.

Animals↗

PubMed1990

Lung function declines in patients with pulmonary sarcoidosis and increased respiratory epithelial permeability to 99mTc-DTPA.

Respiratory epithelial clearance of 99mTc-DTPA (RC-Tc-DTPA) and pulmonary function tests (PFT) were determined at intervals of 6 or 12 months in 37 untreated, nonsmoking patients with sarcoidosis over a period of 6 to 36 months. PFT included the measurements of total lung capacity (TLC), vital capacity (VC), FEV1, and diffusing capacity for carbon monoxide. No difference was found between the respiratory clearance of 113mIn-DTPA (2.25 +/- 1.00%/min) and RC-Tc-DTPA (2.29 +/- 1.11%/min) in eight patients with pulmonary sarcoidosis. Pulmonary function decreased 15% or more in at least 2 function tests during 11 follow-up periods, but it remained stable during 47 follow-up periods. In patients whose lung function deteriorated, RC-Tc-DTPA increased to 3.51 +/- 1.55%/min; in contrast, in patients whose lung function remained stable, regardless of the initial values, RC-Tc-DTPA was normal (1.00 +/- 0.50%/min; p less than 0.001). In eight patients who were treated with corticosteroids, RC-Tc-DTPA decreased from 3.48 +/- 1.31%/min to 1.56 +/- 0.64%/min (p less than 0.001), and PFT improved. We conclude that in nonsmokers with pulmonary sarcoidosis, increased RC-Tc-DTPA is not related to dissociation of 99mTc from DTPA, RC-Tc-DTPA is increased when pulmonary function decreases, and, when increased, RC-Tc-DTPA decreases with corticosteroid therapy.

Adult↗

PubMed1976

Effects of intravenous histamine on static lung compliance and airway resistance in normal man.

Static lung compliance and airway resistance were measured in 30 experiments on 6 healthy subjects after intravenous injection of a bolus of histamine (4 mug per kg of body weight). Analysis of the pooled results showed a significant decrease in static lung compliance (maximal mean decrease,--16 per cent occurring 20 sec after injection). There was no significant change in functional residual capacity or vital capacity after injection of the histamine. Administration of propranolol (a beta-adrenergic blocking agent) did not significantly enhance the responses to histamine. The results suggested that humans, like other species, can constrict peripheral airways sufficiently to produce alterations in the static elastic properties of the lungs.

Adult↗

PubMed1984

Functional and morphologic changes in the lungs after a single intratracheal instillation of silica.

The functional and morphologic consequences in the lungs of a single intratracheal instillation of silica dust were evaluated over 6 months. Male Fischer-344 rats were subjected to pulmonary function tests that measured lung volumes, forced expiratory flows, and carbon monoxide diffusing capacity (DLCO). Then saline (0.7 ml, n = 10) or saline containing either 10 mg (n = 9) or 40 mg (n = 14) of silica dust was instilled in the trachea, and each animal was tested 3, 12, and 24 wk later. Morphologic studies were performed on 27 rats similarly treated (3/group/time). By 3 wk after instillation, the inspiratory capacity, forced vital capacity, and DLCO diminished significantly (p less than 0.01) in the high-dose group. After 3 wk, the response tended to level off. Forced expiratory flows were not significantly affected. By contrast, biochemical analysis of lung collagen content indicated a linear accumulation throughout the experimental period. Microscopic evaluation revealed intra-alveolar accumulation of lipoproteinaceous material (alveolar proteinosis) by 3 wk in both dose groups, which persisted through the 24-wk experimental period. A few fibrotic nodules were seen as early as 3 wk in the 40-mg silica group, and their numbers increased with time, whereas they were relatively sparse in the 10-mg silica group throughout the experimental period, despite the diminished functional measurements. These data suggest a closer temporal correlation of the functional decrements observed to the evolution of the alveolar changes than they do to the development of fibrosis. We conclude that the development of nodular fibrosis was not the major contributing factor to the observed functional changes.

Animals↗

PubMed1997

Maximal respiratory pressures in adult Chinese, Malays and Indians.

Maximal static inspiratory and expiratory mouth pressures (PI,max and PE,max, respectively) enable the noninvasive measurement of global respiratory muscle strength. The aim of this study was primarily to obtain normal values of PI,max and PE,max for adult Chinese, Malays and Indians and, secondarily, to study their effect on lung volumes in these subjects. Four hundred and fifty two healthy subjects (221 Chinese, 111 Malays, 120 Indians) were recruited. Measurements of PI,max from residual volume (RV), PE,max from total lung capacity (TLC) and forced vital capacity (FVC) were obtained in the seated position. There were significant ethnic differences in PI,max and PE,max measurements obtained in males, and FVC measurements in both males and females. Chinese males had higher PI,max values (mean (+/-SD) 88.7+/-32.5 cmH2O) and higher PE,max values (113.4+/-41.5) than Malay males (PI,max 74.0+/-22.7 cmH2O, PE,max 94.7+/-23.4 cmH2O). Chinese males had higher PE,max than Indian males (PI,max = 83.7+/-30.0 cmH2O, PE,max 98.4+/-29.2 cmH2O). There were no significant differences among Chinese females (PI,max 53.6+/-2.3 cmH2O, PE,max 68.3+/-24.0 cmH2O), Malay females (PI,max 50.7+/-18.3 cmH2O, PE,max 63.6+/-21.6 cmH2O) and Indian females (PI,max 50.0+/-15.2 cmH2O, PE,max 60.7+/-20.4 cmH2O). In both sexes, the Chinese had a higher FVC compared with Malays and Indians. After adjusting for age, height and weight, race was still a determinant for PE,max in males, and FVC in both sexes. The FVC only correlated weakly with PI,max and PE,max in both sexes. Ethnic differences in respiratory muscle strength, and lung volumes, occur among Asians. However, respiratory muscle strength does not explain the differences in lung volumes in healthy Asian subjects.

Adult↗

PubMed2005

The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors.

OBJECTIVE: To examine pulmonary function, exercise capacity, and health-related quality of life (HRQoL) among severe acute respiratory syndrome (SARS) survivors. METHODS: We evaluated survivors with confirmed SARS at the Prince of Wales Hospital, Hong Kong, at 3, 6, and 12 months after symptom onset. Our assessment included: lung volume (total lung capacity [TLC], vital capacity, residual volume, functional residual capacity), spirometry (FVC, FEV1), diffusing capacity of the lung for carbon monoxide (D(LCO)), inspiratory and expiratory respiratory muscle strength, 6-min walk distance (6MWD), chest radiographs (CXRs), and HRQoL by Medical Outcomes Study 36-Item Short-Form General Health Survey questionnaire. RESULTS: Ninety-seven patients completed the serial assessments. There were 39 male and 58 female patients, and 63 patients (70%) were health-care workers (mean age, 36.9 years [SD, 9.5 years]; body mass index, 23.7 kg/m2 [SD, 4.0 kg/m2]). At 1 year, 27 patients (27.8%) had abnormal CXR findings. Four patients (4.1%), 5 patients (5.2%), and 23 patients (23.7%) had FVC, TLC, and D(LCO) values < 80% of predicted values, respectively. The 6MWD at 12 months was 511.0 m (SD, 89.8 m), which was higher than at 3 months (mean difference, 47.0 m; 95% confidence interval [CI], 31.8 to 62.1 m; p < 0.01) but not different from 6 months (mean difference, 9.7 m; 95% CI, - 4.4 to 23.8 m; p = 0.18). The 6MWD was lower than that for normal control subjects of the same age groups, and there was impairment of HRQoL at 12 months. Patients who required ICU admission (n = 31) showed higher CXR scores (1.6 [SD, 3.1]; vs 0.4 [SD, 1.1]; p = 0.04) and lower percentage of predicted FVC, TLC, and Dlco than those who did not, but there were no differences in 6MWD and health status. CONCLUSION: Significant impairment in Dlco was noted in 23.7% of survivors 1 year after illness onset. Exercise capacity and health status of SARS survivors were remarkably lower than those of a normal population.

Adult↗

PubMed1977

Acute supine respiratory failure due to bilateral diaphragmatic paralysis.

This report documents the first known case of bilateral diaphragmatic paralysis following blunt trauma to the chest. The important role of diaphragmatic function in maintaining ventilation, particularly with the patient in the supine position, is illustrated by the reduced total lung capacity, functional residual capacity, and vital capacity. Severe hypoxemia with the patient in the supine position, was markedly improved by elevation of the patient to 30 degree and was further improved by sitting the patient upright. Following an initial period of acute respiratory failure, the patient was managed acceptably by maintaining an elevated position for sleeping until diaphragmatic function returned, about nine months after the injury.

Accidents, Traffic↗

PubMed2003

Interferon gamma-1b therapy for advanced idiopathic pulmonary fibrosis.

OBJECTIVE: To report on observations made in a group of patients with idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) who were treated with interferon gamma-1b. PATIENTS AND METHODS: We reviewed the clinical records, radiological studies, and pulmonary function data of all patients treated with interferon gamma-1b between January 2000 and March 2002 at the Mayo Clinic in Rochester, Minn. RESULTS: Twenty-one patients (mean age, 68 years; range, 52-80 years) were treated with interferon gamma-1b for a mean duration of 82 months (range, 3-21 months). All patients had been diagnosed previously as having IPF/UIP based on clinical, pulmonary function, and chest high-resolution computed tomographic scan criteria; 12 patients had also undergone video-assisted thoracoscopic surgical lung biopsy. Baseline pulmonary function data (mean +/- SEM percent predicted) were as follows: total lung capacity, 57.3 +/- 2.5; vital capacity, 55.0 +/- 3.3; diffusing capacity of lung for carbon monoxide, 39.7 +/- 2.8; and forced expiratory volume in 1 second, 58.1 +/- 3.6. Only 1 patient showed symptomatic and functional improvement, and 7 discontinued treatment because of a perceived lack of benefit. Eleven patients (52%) died after a mean of 6.4 months of treatment, and follow-up pulmonary function data suggested continued worsening in all but 1 patient. CONCLUSION: These observations do not support the use of interferon gamma-lb therapy for patients with advanced IPF/UIP.

Aged↗

PubMed2003

Lung function impairment in relation to asbestos-induced pleural lesions with reference to the extent of the lesions and the initial parenchymal fibrosis.

OBJECTIVES: The study focused on the effect of pleural lesions on the lung function of asbestos-exposed workers. METHODS: A clinical check-up, chest radiography, high-resolution computed tomography (HRCT), and lung function testing were performed on 162 asbestos-exposed workers without any sign of parenchymal fibrosis on their chest radiographs. According to the HRCT scans, two subgroups were delineated, 97 subjects with pleural lesions and 65 referents without pleural lesions. Four categories of pleural lesions were specified according to the extent. Parenchymal changes, if identified on the HRCT scans, were recorded. RESULTS: The radiographic sensitivity and specificity for pleural lesion detection when compared with that of HRCT were 64.9% and 98.5%, respectively. The HRCT scans showed parenchymal abnormalities in 46.3% of the participants, more frequently in those with pleural lesions (67.0% versus 15.4%, P<0.0001). After the effect of parenchymal fibrosis was taken into account, pleural lesions were found to have a significant effect on the decrease in total lung capacity, forced vital capacity, and forced expiratory volume in 1 second, if being classified into category 2 or higher. CONCLUSIONS: Pleural lesions proved to have a negative effect on lung function, depending on their extent. The effect of the initial parenchymal fibrosis detectable in the HRCT scans only was also significant. A normal chest radiograph does not exclude the presence of pleural lesions or initial parenchymal fibrosis, with a possible negative effect on lung function.

Asbestosis↗

PubMed2003

Pulmonary function study in the identified critically polluted areas of Talcher (Orissa).

Angul-Talcher area of Orissa is an industrial complex of diversities of industries, which released large number of pollutants into the environment causing environmental pollution and affect the community people as well as the workers working there. Considering the magnitude of the problem pulmonary function study had been carried out in to the community people of this polluted area. The pulmonary function tests (PFT) were carried out in 1099 male and 1072 female subjects except the children below the age of 10 years. Vital capacity (VC) and Forced vital capacity (FVC) were recorded in standing posture. Forced expiratory volume in one second (FEV1) and its percentage (FEV1%) were calculated. The PFT results indicated that in male and female subjects of 10-19 year age group the FVC values were significantly lowered in exposed villagers in comparison to control subjects. In all other age ranges some of the differences have been found to be significant at various levels. The mean values of FVC and FEV1 were higher in control villagers of most of the age groups than that of the exposed villagers PFT values were also presented according to smoking habit. Restrictive type of PFT impairment were noticed more. The male villagers of Gurjunguli showed the maximum - 40.9% followed by Digghi-39.1%, Kulad-35%, Tentuli- 23.4%, Bonda - 16.3%, Gadarkhai-15.4% and Balanda-13.5%. In females the sequence of having higher incidence rate of restrictive diseases were Digghi-37.0%, Tentuli-29.0%, Gurjunguli-25.3%, Kulad - 21.5%, Gadarkhai - 15.3%, Balanda - 15.3% and Bonda - 13.7%. In control village restrictive impairment were 10.7% in male and 7.4% in females. Obstructive types of impairments are comparatively less than restrictive type of impairments. Control male and female subjects had 7.1% and 5.7% of obstructive impairments and they are mostly belonged to higher age groups. In exposed villages obstructive impairments were found in Godarkhai - 6.4%, Kulad - 5.0%, Digghi - 4.2%, Tentuli - 2.6% and Balanda - 1.8% in males and the corresponding figures 5.0%, Digghi - 4.2%, Tentuli - 2.6% and Balanda - 1.8% in males and the corresponding figures in the females were Gadarkhai - 3.0%, Kulad - 2.6%, Digghi - 3.7% Tentuli - 3.0%) and Balanda - 4.0% respectively. The combined types of impairments were more in exposed subjects and they were belonged to higher age groups. The higher prevalence's might be due to the pollution effects of industries situated in and around the concerned villages. Categorically mild type of obstructive impairments was more in control subjects and they belonged to 50 and above year's age group. It is well known that the higher age accounted for lowering PFT values, which might be in the form of mild obstruction.

Adolescent↗

PubMed1991

[Pulmonary histiocytosis X].

This is a report on 2 adult patients suffering from pulmonary histiocytosis X. The aetiology and the diagnostic and therapeutic approach are discussed on the basis of a review of the literature. This is a rare disease that is triggered by a virus and immunologically conditioned, the disposition being genetically transferred. It is characterised by cells known as histiocytosis X cells with typical X bodies and immunocytochemically identifiable S 100 antigen. It will usually be necessary to perform an open biopsy of the lung to determine the histology of histiocytosis X. Roentgenologically pathognomonic signs are in particular ring-shaped structures of up to 5 mm diameter with a marginal edge. Lung function analysis revealing hypoxaemia after stress and, less significantly, diffusion capacity and vital capacity, are also among the most sensitive data pointing to histiocytosis X. Indication for treating the patients, who usually do not display prominent signs and symptoms, should be discrete because spontaneous remissions occur very frequently. If the patients display relevant signs and symptoms, corticosteroid long-term treatment over 12 months with 0.5-1.0 mg/kg body weight per day is recommended employing a slowly and progressively reduced dosage schedule. Chemotherapeutic drugs or thymus extracts are administered in a few rare instances.

Adrenal Cortex Hormones↗

PubMed1989

Pulmonary permeability in primary ciliary dyskinesia.

Pulmonary clearance (Pcl) of aerosolized 99mTc-DTPA was studied in fourteen patients with primary ciliary dyskinesia (PCD), (median age 23.5 yrs, range 12-44 yrs) and nine normal individuals (median age 23 yrs, range 18-27 yrs). All had never smoked. Regional Pcl was studied for arbitrarily defined central and peripheral regions of the lung using a gamma camera method, whilst total Pcl was studied by a plasma sample method. The patients with PCD had significantly reduced total Pcl compared to the normal individuals (p less than 0.05) and also significantly lower total lung capacity (TLC), vital capacity (VC), forced expiratory volume in one second (FEV1), and FEV1/VC values (p less than 0.05). There was no correlation between Pcl and FEV1/VC. It is concluded that the reduced Pcl in the PCD patients may be associated with their small lung volumes. In addition, reduced bronchial clearance of surfactant in PCD may be associated with an increased alveolar lining fluid volume and/or an impaired movement of 99mTc-DTPA along the alveolar septa to the bronchoalveolar junction, where the epithelium may be more specialized for absorption.

Adolescent↗

PubMed1986

Pulmonary function in chronic renal failure patients managed by continuous ambulatory peritoneal dialysis.

The influence of intraperitoneal fluid on pulmonary function was studied in 20 unselected continuous ambulatory peritoneal dialysis (CAPD) patients, all but one of whom had at least one cardiorespiratory disorder. Measurements of pulmonary function were made with the abdomen empty and following the instillation of 2 1 of dialysis fluid (full). Functional residual capacity fell with the peritoneal cavity full, due to decreases in residual volume, and expiratory reserve volume, but there was a corresponding increase in inspiratory capacity. The vital capacity remained unchanged and the total lung capacity fell only slightly. The FEV1, diffusing capacity, and distribution of ventilation were unaltered. These findings can be attributed to an increase in intra-abdominal pressure resulting in elevation of the diaphragm and increased diaphragmatic contractility. We conclude that the instillation of 21 of dialysis fluid in CAPD patients with cardiorespiratory disease does not result in a clinically significant deterioration in these aspects of pulmonary function.

Adult↗

PubMed1986

Reference values of regional ventilation, lung volumes and perfusion assessed by using an automated multidetector 133-Xe radiospirometer.

The distributions of ventilation, lung volumes and perfusion were studied in 56 healthy non-smoking Finnish adults to get reference values for a computerized 133-Xe radiospirometer with 16 detectors and moveable designed collimators (Valmet BI 1200). The age of the subjects ranged from 20 to 60 (mean 36.5, SD 9.1) years. Thirty-one of them were men. In addition, the reproducibility of the method was tested in 13 patients with pulmonary diseases. The measurements were made with the subjects in supine position. The studied variables showed no correlation with sex or age. The interpulmonary and intrapulmonary percentage distributions between 16 pulmonary subareas were calculated for the following variables: ventilation (V) (assessed from wash-in curves), functional residual capacity (FRC), vital capacity (VC), total lung capacity (TLC), wash-out time during tidal breathing (T1/2 V), perfusion (Q) (at TLC level), wash-out time after breath-holding during the perfusion study (T1/2 Q), specific ventilation (V/FRC), specific perfusion (Q/TLC), and V/Q ratio. The percentage proportion (mean and SD) in the right lung of V was 50.5 (2.6), of FRC 51.7 (2.1), of VC 51.0 (1.8), of TLC 51.1 (1.7), and of Q 50.8 (3.0). Apical parts of the lungs showed smaller functional proportions than the other parts. There was a significant tendency to increasing basal and decreasing apical proportions of V, VC, TLC and FRC with increasing height and weight. Coefficients of variation (CoV) of the distribution indices for the whole lung varied between 1.9 and 5.0%. We suggest that the distribution data obtained here are helpful in clinical work when evaluating the distributions in patients studied with the Valmet BI 1200 radiospirometer.

Adult↗

PubMedDate not supplied

[Changes in the spirography of paraplegics related to different postures in the air and water].

Respiratory insufficiencies in subjects with spinal cord injury were studied in five situations: in the air (sitting, dorsal supine position, declivous--15 degrees), and immersed in water up to the neck (sitting, dorsal supine position). Results were compared to those for a group of normal subjects. Total lung capacity (TLC), residual volume (RV), functional residual capacity (FRC), vital capacity (VC), forced expiratory volume per second (FEV1) and peak expiratory flow (PEF) were measured and their ratios with theoretical values of each subject were calculated. In handicapped subjects, FEV1 is less significantly diminished than VC and PEF. TLC does not vary, FRC is higher only sitting in the air, RV is more increased. Between situations, FEV1 never varies. In normal subjects, RV does not vary but, sitting in the air, TLC, VC, FRC and PEF increase. In handicapped subjects sitting in the air, VC decreases, RV and FRC increase, TLC and PEF do not vary. In normal and handicapped subjects, the other situations are comparable all together.

Adolescent↗

PubMed1995

Biochemical and functional markers of lung damage after bleomycin treatment.

Lung function tests, including spirometry, and pulmonary transfer factor for carbon monoxide (TLCO), serum angiotensin-converting enzyme (sACE), serum copper (sCU++) and serum procollagen III peptide (sPIIIP) were measured in 20 patients with metastatic testicular carcinoma, before and after treatment with cisplatin, bleomycin, vinblastine or etoposide. A significant decrease of TLCO, total lung capacity and vital capacity was observed at the end of the treatment. No recovery of pulmonary function had taken place 2 yrs after the last dose of bleomycin. This result suggests that bleomycin-induced lung damage is not completely reversible. Serum angiotensin-converting enzyme, remained unmodified, whilst sPIIIP was found to be significantly increased at the end of chemotherapy, but normal 2 yrs after the completion of chemotherapy. Serum Cu++ showed a tendency to decline. No significant correlation was found between sACE, sCu++ and sPIIIP and lung function tests in the follow-up period. These results question the possibility that these markers could be useful indicators of bleomycin-induced lung damage.

Adult↗