SEARCH · PubMed Health

Results for “left variable region”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,027 records · Page 57Linked to original sources

PubMedDate not supplied

Epileptiform EEG activity of the centromedian thalamic nuclei in children with intractable generalized seizures of the Lennox-Gastaut syndrome.

Centromedian thalamic nuclei (CM) epileptiform EEG activities were recorded in children with intractable generalized seizures of Lennox-Gastaut syndrome (LGS) through implanted recording-stimulating electrodes used for seizure control. Ictal CM epileptiform activities were consistently correlated to widespread surface cortical EEG activities and symptoms in all patients and all types of generalized seizures; i.e., fast spike discharges at CM correlated at onset of tonic and tonic-clonic generalized seizures; slow (1-2 Hz) spike-wave complex discharges at CM correlated for atypical absence seizures; slow polyspike-wave complex discharges correlated for myoclonic seizures; and spike bursts and suppression patterns correlated for combined tonic-atonic-myoclonic seizures. Ictal EEG activities occurred simultaneously at right and left CM and surface at onset of all seizure types, with the exception of myoclonic seizures where CM complete discharges and individual spike-wave complexes significantly lead those of the surface. Brief tonic-atonic spasms clinically undistinguishable from "real" epileptic seizures showed no EEG counterparts at CM and surface. Interictal CM spike-wave complete discharges and individual spike-wave complexes showed variable amplitude-temporal patterns. Amplitude emphasis on CM and frontopolar regions was observed in most of complete discharges, however, and phase shifts between CM and frontopolar regions were observed in individual spike-wave complexes.

Adult↗

PubMed1995

Characterization of shock-induced action potential extension during acute regional ischemia in rabbit hearts.

INTRODUCTION: Defibrillation shocks produce extension of the myocardial action potential repolarization time (AP extension) in nonischemic myocardium. AP extension may synchronize repolarization in the heart because the extension increases when shock timing is increased. We tested whether AP extension occurs and whether it increases when shock timing is increased in regionally ischemic isolated perfused rabbit hearts stained with the transmembrane voltage sensitive fluorescent dye, di-4-ANEPPS and given diacetyl monoxime to eliminate motion artifacts. METHODS AND RESULTS: Before and after left anterior descending (LAD) coronary artery occlusion, APs were recorded on the anterior left ventricular epicardium with an epifluorescence measurement system. Hearts were paced with a train of 10 stimuli (S1) and then during the 10th AP were given a defibrillation shock (S2) from epicardial electrodes on either side of the recording region. Before LAD occlusion, duration of the 9th S1-induced AP measured at full repolarization was 171 +/- 11 msec (mean +/- SD). Within 15 minutes after LAD occlusion, the AP duration became shorter (P < 0.05) and more variable (137 +/- 47 msec), and APs with negligible plateaus were observed. Extension of the 10th AP by S2 was significant both before (mean extension of 59 to 65 msec for three S2 waveforms tested) and after LAD occlusion (mean extension of 35 to 41 msec). Unlike the results before LAD occlusion, AP extension after occlusion was independent of absolute shock timing expressed in msec. When timing was expressed as a fraction of individual AP durations, AP extension after occlusion increased with increases in shock timing. CONCLUSIONS: Shocks extend APs during ischemia; however, absolute time dependence of AP extension is not constant among cells that have different AP durations during ischemia. This may influence postshock repolarization synchrony when different AP durations exist in different parts of regionally ischemic hearts.

Action Potentials↗

PubMed2004

Neurobrucellosis: clinical and neuroimaging correlation.

BACKGROUND AND PURPOSE: Manifestation of nervous system involvement by neurobrucellosis, a treatable infection, is not well documented. We investigated patterns of nervous system involvement and determined if neuroimaging abnormalities correlated with clinical manifestations of neurobrucellosis. METHODS: We reviewed 23 MR imaging studies (17 of brain, six of spine) and seven CT scans of brain in 23 patients (14 male and nine female patients; age range 17-71 years) with positive Brucella titers in their serum and CSF. RESULTS: Twelve patients had central nervous system (CNS) involvement, four had peripheral nervous system (PNS) involvement, two had combined PNS and CNS involvement, and five had isolated hearing loss. Imaging findings were variable: five of seven brain CT studies were normal, and 10 of 23 MR studies were normal (eight brain, one thoracic, one lumbar). One brain CT study showed subthalamic hemorrhage, mild perivascular enhancement, left caudate lacunae, and diffuse white matter changes. One other brain CT study showed enhancement of the tentorium in addition to white matter changes. Abnormal MR findings were basal meningeal enhancement (n = 3), lumbar nerve root enhancement (n = 3), granuloma of the suprasellar region (n = 1), diffuse white matter changes (n = 7), and spinal cord atrophy (n = 1). All patients improved after treatment with three antimicrobial drugs for 3-12 months. Seven patients had follow-up imaging; the enhancement disappeared but the white matter and ischemic changes persisted despite almost complete clinical recovery. CONCLUSION: Clinical-radiologic correlation in neurobrucellosis varies from a normal imaging study despite positive clinical findings, to a variety of imaging abnormalities that reflect either an inflammatory process, an immune-mediated process, or a vascular insult.

Adolescent↗

PubMedDate not supplied

Effects of AQ-AH 208, a new specific bradycardic agent, on myocardial ischemia-reperfusion injury in anesthetized dogs.

The effects of a new specific bradycardic agent, AQ-AH 208--3,4-dihydro-6,7-dimethoxy-2-[3-( [ 2-(3,4-dimethoxyphenyl)-ethyl]-aminoethyl)-propyl ]-1(2H)isochinolinon--on ischemia-reperfusion-induced myocardial infarct size following a 2-h occlusion and 30-min reperfusion period of the left anterior descending coronary artery (LAD) were determined in anesthetized dogs. Regional myocardial blood flow was measured by use of radioactive microspheres (15 micron), and tissue injury was determined by use of the triphenyltetrazolium chloride histochemical stain. In two groups of dogs, vehicle (saline) or AQ-AH 208 (500-micrograms/kg bolus followed by 25 micrograms/kg/min) was administered intravenously 10 min prior to LAD occlusion and infused throughout the occlusion and reperfusion periods. In a third group, AQ-AH 208 was given 10 min after LAD occlusion and infused throughout the remainder of the experiment. AQ-AH 208 treatment resulted in a significant reduction in heart rate and heart rate-systolic pressure product during occlusion and reperfusion. AQ-AH 208 produced variable increases in collateral blood flow as compared with the saline-treated group 20 min and 2 h following LAD occlusion. These increases in collateral perfusion were primarily to the midmyocardium and subendocardium, as reflected by increases in the endocardial/epicardial blood flow ratio (endo/epi). During reperfusion, subendocardial flow was significantly elevated and subepicardial flow reduced in both AQ-AH 208-treated groups, as compared with control, and the endo/epi was markedly increased. In all three groups, left ventricular weight, area at risk, percent of the left ventricle at risk, and retrograde flow and pressure prior to drug treatment were similar.(ABSTRACT TRUNCATED AT 250 WORDS)

Anesthesia↗

PubMed1978

The topographical anatomy and blood supply of the carotid body region of the domestic fowl.

The topographical anatomy of the carotid body region was investigated on both sides in 30 adult domestic fowls (Gallus gallus domesticus). On each side of the body the two parathyroid glands always adhered to each other, the caudal gland being the smaller. The right cranial parathyroid usually touched the thyroid gland, but on the left side the two glands were nearly always separate. The ultimobranchial gland was usually attached to the parathyroid glands on the left side, but was always well separated on the right side. The carotid body, the identity of which was checked by light and electron microscopy, was ovoid in shape, whitish in colour, and about 0.8 x 0.6 x 0.5 mm in size. It was almost always in direct contact with the medial surface of one or both parathyroid glands have commonly been portrayed astopographically separate from each other. The oesophagotracheobronchial artery, the artery to the carotid body, and the caudal thyroid artery arose close together, though in variable positions, from the lateral aspect of the common carotid artery. The artery to the carotid body was always the middle of the three. The venous drainage of the carotid body was associated with the veins of the parathyroid and ultimobranchial glands. The carotid body was innervated by a filament from the distal vagal ganglion. The topographical observations on the carotid body region have been compared with those of other authors. The cranial and caudal parathyroid glands have commonly been portrayed as topographically separate from each other. The carotid body has seldom been depicted in direct contact with the parathyroid glands. The size of the carotid body has invariably been shown far too large. These discrepancies are discussed and are attributed largely to the reliance by other authors on serial reconstruction rather than microdissection.

Animals↗

PubMed1992

EAMI--exercise training in anterior myocardial infarction: an ongoing multicenter randomized study. Preliminary results on left ventricular function and remodeling. The EAMI Study Group.

To determine the effects of a 6-month exercise training program on left ventricular (LV) function and remodeling, 49 consecutive patients (pts) with first Q anterior myocardial infarction (51 +/- 8 years), in I-II NYHA class, were studied 4 to 8 weeks after the acute episode and 6 months later by 2D-ECHO and upright bicycle ergometric test. At entry, pts were randomly allocated to physical training (T = 25pts) or control (C = 24pts). Global endocardial surface area (ESA), LV volumes and EF, extent of abnormal wall motion (%WMA), of regional dilatation (%REG DIL), and the shape distortion (DIST) index were analyzed. After 6 months, a significant increase in work capacity (4,589 +/- 1,417 to 5,379 +/- 1,485 KPM/min, p less than 0.03) and in lactic anaerobic threshold (45 +/- 13 to 63 +/- 15 W, p less than 0.01) was observed only in T. Initial ESA, EDV, EF, %WMA, %REG DIL, and DIST index were similar and they did not change after 6 months in both groups. However, pts with less than 40%EF had greater (p less than 0.0001) EDV and %WMA with marked DIST index at entry and showed further (p less than 0.01) deterioration after 6 months both in C and in T (EDV, ml/m2: 68 +/- 12 to 77 +/- 18 in C, 71 +/- 12 to 74 +/- 18 in T; %REG DIL: 39 +/- 20 to 49 +/- 24 in C, 32 +/- 12 to 35 +/- 23 in T; DIST index: 0.16 +/- 0.07 to 0.21 +/- 0.09 in C, 0.2 +/- 0.07 to 0.22 +/- 0.1 in T). These variables did not change in pts with greater than 40%EF. Thus, from these preliminary data, pts with less than 40%EF at entry are prone to further global and regional LV deterioration. Physical training does not seem to increase this spontaneous deterioration.

Anaerobic Threshold↗

PubMed1995

Diaphragmatic microcirculation measured by laser-Doppler flowmetry in the rat.

The applicability of laser-Doppler flowmetry (LDF) in measuring regional blood flow of the diaphragm (Qdi) was evaluated in anesthetized and mechanically ventilated rats. Specifically, we assessed the issues of the degree of tissue perfusion, spatial variations of Qdi signals, and the correlation between these signals and total Qdi. Qdi was detected from an area 1 mm in diameter and 0.5 mm in depth. With Ringer solution continuously suffusing the abdominal surface of the left hemidiaphragm, drugs were applied to the surface of the diaphragm at 1/100 of the flow rate of the suffusing fluid. In 13 rats, resting Qdi and the response of Qdi to a single concentration of adenosine (10(-4) M) remained unchanged over a 2-h period. Increasing adenosine concentrations (10(-9) to 10(-3) M) in eight rats elicited a progressive rise in Qdi. In six rats, the variability of Qdi in a given rat was assessed over five different sites at 2-mm intervals in a line on the diaphragm. A wide range of variability in Qdi was noticed among different sites. The depth of tissue penetration of LDF was little affected when a piece of freshly diaphragm was interposed between the probe and the perfused diaphragm, suggesting that LDF signals arise from complete penetration of the perfused diaphragm. Finally, significant linear relationships between mean Qdi and total Qdi were observed in all animals; however, the slopes of these relationships varied significantly between animals. In conclusion, LDF provides a stable and continuous method for monitoring regional microvascular diaphragmatic perfusion.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenosine↗

PubMed1998

Cerebral and cerebellar activation in correlation to the action-induced dystonia in writer's cramp.

The pattern of brain perfusion of four patients with writer's cramp and four control subjects were examined using positron emission tomography scans after [(15)O] butanol injections. Each subject was scanned 12 times to cover three repetitions of four different motor tasks with the right hand. Drawing of horizontal lines and variable durations of the writing of a prelearned text were performed in a pseudorandom order, the latter task commencing either simultaneously with or 30 sec or 120 sec before the tracer injection. The perceived difficulty and signs of dystonia progressed in correlation to the duration of writing. Statistical parametric maps were calculated to test hypotheses of regional specific effects dependent on the performed motor tasks. The patients with writer's cramp had progressively increased activity in the left primary sensorimotor and premotor cortices, the left thalamus, and the cerebellum with a right-side predominance in correlation to the duration of writing. The regions with activity increases thus corresponded to a cerebrocerebellar motor circuit. The duration of writing correlated to a progressive reduction of activity in the patients' left supramarginal and angular gyri (Brodmann areas 40 and 39) and an inferior part of the left temporal lobe (area 20). The control subjects had neither a significant increase or decrease of activity in correlation to the duration of writing. Group-specific differences were confirmed statistically in split-plot interaction analyses.

Adult↗

PubMed1987

The signal-averaged electrocardiogram as a screening test for inducibility of sustained ventricular tachycardia in high risk patients: a prospective study.

The role of the signal-averaged electrocardiogram in predicting the induction of sustained monomorphic ventricular tachycardia in high risk patients was assessed prospectively in 100 consecutive patients. Presenting diagnoses were syncope (38 patients), nonsustained ventricular tachycardia (24 patients), sustained ventricular tachycardia (25 patients) and sudden cardiac arrest (13 patients). Using programmed ventricular stimulation, 71 patients (group I) did not have and 29 patients (group II) did have inducible sustained monomorphic ventricular tachycardia. Using the signal-averaged electrocardiogram with filtering (6 dB/octave) at high pass corner frequencies of 67 and 100 Hz, the two groups were compared. The signal-averaged electrocardiogram was considered abnormal if all of the following criteria were satisfied: 1) the total filtered QRS complex duration was greater than 120 ms, 2) the duration of the terminal QRS complex of less than or equal to 20 microV was greater than or equal to 30 ms, and 3) at least one deflection (late potential) was present in this region. Differences between groups I and II in these three measures were highly significant (p less than or equal to 0.001). The sensitivity and specificity of signal averaging for predicting the induction of sustained ventricular tachycardia were 93 and 94%, respectively. Stepwise logistic regression analysis identified the signal-averaged electrocardiogram as the best predictor of induction of sustained monomorphic ventricular tachycardia, independent of left ventricular ejection fraction, presence of ventricular aneurysm, myocardial infarction and other clinical variables (chi-square = 93.2, p less than 0.0001). The signal-averaged electrocardiogram is a sensitive and specific test for the induction of sustained monomorphic ventricular tachycardia, having independent predictive value.

Coronary Disease↗

PubMed2003

Functional anatomy of pitch memory--an fMRI study with sparse temporal sampling.

Auditory functional magnetic resonance imaging tasks are challenging since the MR scanner noise can interfere with the auditory stimulation. To avoid this interference a sparse temporal sampling method with a long repetition time (TR = 17 s) was used to explore the functional anatomy of pitch memory. Eighteen right-handed subjects listened to a sequence of sine-wave tones (4.6 s total duration) and were asked to make a decision (depending on a visual prompt) whether the last or second to last tone was the same or different as the first tone. An alternating button press condition served as a control. Sets of 24 axial slices were acquired with a variable delay time (between 0 and 6 s) between the end of the auditory stimulation and the MR acquisition. Individual imaging time points were combined into three clusters (0-2, 3-4, and 5-6 s after the end of the auditory stimulation) for the analysis. The analysis showed a dynamic activation pattern over time which involved the superior temporal gyrus, supramarginal gyrus, posterior dorsolateral frontal regions, superior parietal regions, and dorsolateral cerebellar regions bilaterally as well as the left inferior frontal gyrus. By regressing the performance score in the pitch memory task with task-related MR signal changes, the supramarginal gyrus (left>right) and the dorsolateral cerebellum (lobules V and VI, left>right) were significantly correlated with good task performance. The SMG and the dorsolateral cerebellum may play a critical role in short-term storage of pitch information and the continuous pitch discrimination necessary for performing this pitch memory task.

Adolescent↗

PubMed2001

Predictors of left ventricular function after acute myocardial infarction: effects of time to treatment, patency, and body mass index: the GUSTO-I angiographic experience.

BACKGROUND: Despite the significant survival benefit associated with successful reperfusion therapy for acute myocardial infarction, global indices of outcome left ventricular function, such as ejection fraction, have often demonstrated little or no improvement. Although these measurements are confounded by numerous clinical, physiologic, and angiographic variables, no comprehensive analysis of this issue in a large series of patients is available. We used the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I) database to better understand this phenomenon by determining independent predictors of left ventricular function and their interplay with regard to outcome ventricular function and improvement in function during the initial postinfarction week. METHODS: Ninety-minute and 5- to 7-day posttreatment global and regional indices derived from left ventriculograms were analyzed from a population of 676 patients. These observations were combined with clinical data to describe independent determinants of ventricular function outcome. RESULTS: Clinical factors predictive of global and regional ventricular function as well as improvement in function between 90 minutes and 5 to 7 days included time to treatment, early infarct-related artery flow grade, and body mass index. These same factors contribute significantly to compensatory hyperkinesis of the noninfarct zone, which is critical to maintenance of global ventricular function during this time period. CONCLUSIONS: The ventricular function benefits of early complete reperfusion after myocardial infarction are readily demonstrable after adjustment for multiple covariables and include (1) maintenance of global ventricular function and (2) prevention or delay in ventricular dilatation.

Aged↗

PubMed1995

Heart rate variability and inappropriate sinus tachycardia after catheter ablation of supraventricular tachycardia.

Sinus tachycardia has been reported after radiofrequency catheter ablation of supraventricular tachycardia. Frequently, these patients require beta-blocking agents for symptomatic control. The purpose of this study was to evaluate prospectively the incidence of inappropriate sinus tachycardia and heart rate variability after ablation of atrioventricular nodal reentrant tachycardia and accessory pathways. Patients undergoing ablation had 24-h ambulatory monitoring ECG (Holter) performed before the procedure, on the day of the ablation, and 3 months afterwards. There were 170 patients, mean age 48 +/- 23 years; 93 were female. A complete study of the 24-h Holter with analysis of heart rate variability: SD, rMSSD, pNN50, high and low frequency was obtained. There was a low prevalence of inappropriate sinus tachycardia after the ablation procedure (10 of 170 patients: five with four atrioventricular nodal reentry, with posteroseptal accessory pathways and one of the latter following ablation of the left accessory pathway). There was no modification of time and frequency domain parameters of heart rate variability in the remaining patients who underwent radiofrequency ablation. Holter monitoring 3 months after ablation showed that parameters of heart rate and heart rate variability had normalized in patients who had developed inappropriate sinus tachycardia. Inappropriate sinus tachycardia may be initiated by both radiofrequency ablation of atrioventricular nodal reentrant tachycardia and radiofrequency ablation of posteroseptal accessory pathways. Specific damage to the posteroseptal region is responsible for these changes, which usually recover spontaneously after 3 months.

Adult↗

PubMed2001

Quantification of coronary artery lumen volume by digital angiography: in vivo validation.

BACKGROUND: Coronary artery lumen volume may potentially have several advantages over the commonly used variables, such as percent stenosis or minimal lumen diameter, in the assessment of coronary artery disease. The goal of this study is to validate a quantitative assessment of lumen volume using a video densitometry technique. METHODS AND RESULTS: Coronary arteriography was performed in 9 swine (body weight 20 to 55 kg) after power injection of contrast material (2 mL/s for 3 seconds) into the left main coronary artery. Phase-matched subtracted images were used to quantify regional lumen volume by a video densitometry technique. The in vivo volume measurements were validated by a polymer cast of the coronary arterial tree made at physiological pressure. The measured cast volume (V(C)) and video densitometric regional lumen volume (V(VD)) were related by V(VD)=1.06 V(C)-0.01 mL (r=0.99). The root mean square and systematic errors for these measurements were 17% and -3%, respectively. CONCLUSIONS: A video densitometry technique for quantification of coronary lumen volume was validated both in vitro and in vivo in a swine animal model. The present results demonstrated the feasibility and potential utility of the video densitometry technique for accurate measurement of regional lumen volume in vivo. This study contributes to the understanding of the angiographic methods used for the assessment of coronary artery disease and indicates that this technique can potentially be used for quantification of diffuse coronary artery disease during routine coronary arteriography.

Angiography, Digital Subtraction↗

PubMed2004

Factors in the interictal record predicting an ictal episode: a case study.

This report deals with a patient with intractable seizures, who had 64 subdural electrodes implanted onto the left frontal and temporal cerebral cortex in anticipation of probable seizure surgery. One specific region on the left frontal lobe proved to be the focus for both the interictal spikes and also for the ictal activity. Our goal was to determine what electrical characteristics in the interictal record predicted the ictal episodes. The number of interictal spikes and also the amount of fast activity (15-128/sec) progressively increased before each of the 5 ictal episodes; an analysis showed that the number of spikes and their frequency proved the more significant variable. One other characteristic that changed before the ictal episodes was a great decrease in the interval between spikes as an example of a diminishing variability or increasing periodicity. Thus, the important factors in the interictal record that lead to an ictal event are the number of spikes, the amount of fast activity and the decreasing variability between the spikes.

Adult↗

PubMed1985

Localization of binding sites for concanavalin A, Ricinus communis I and Helix pomatia lectin in the Golgi apparatus of rat small intestinal absorptive cells.

Binding sites for concanvalin A (Con A), Ricinus communis I agglutinin (RCA I), and Helix pomatia lectin (HPA) were localized in the Golgi apparatus of rat small intestinal absorptive cells. A preembedment technique, a modification of the one originally used by Bernhard and Avrameas (Exp Cell Res 64:232, 1971), was employed, with horse-radish peroxidase being used for cytochemical visualization. Incubations were performed on 10 microns thick cryosections of duodenal segments that were fixed in a mixture of 4% formaldehyde and 0.5% glutaraldehyde; fixation was preceded by a 2-min rinse in 0.1 M sodium cacodylate and followed by storage in the same buffer for up to 7 days. Incubation with Con A, which binds preferably to alpha-D-mannose and alpha-D-glucose residues, caused intense reaction of the dilated cisternae of the cis Golgi side; staining was variable in intermediate and trans cisternae. RCA I, recognizing beta-D-galactose residues, could only be demonstrated in intermediate cisternae. Reaction for HPA, which indicates alpha-N-acetyl-D-galactosamine residues, stained intensely 1 to 2 cisternae of the cis Golgi side, as well as being localized in the peripheral regions of the cisternae of the intermediate compartment of the stacks. Deposits of reaction product covered the luminal surface of the cisternal membranes, but usually left the lumen itself, as well as lipid particles, devoid of reaction. The differences in Con A, RCA I, and HPA reactivity between cis, intermediate, and trans cisternae suggest compositional and structural differences of the carbohydrates in the respective compartments; they may reflect conversion processes that are known to occur in the oligosaccharide side chains of glycoconjugates at the Golgi complex level.

Absorption↗

PubMed1995

Surface morphology of quail ovaries in late embryonic stages.

Embryonic quail ovaries were examined with a scanning electron microscope. The same as in many bird species, the quail ovary degenerated on the right side, and normal development occurred only on the left side. The surface of the developing left ovary had a rough appearance. The epithelial cell surface was extremely swollen with many globular protrusions, and the cell borders were lined by ridge-like protrusions. On the other hand, the degenerating right ovarian surface was rather smooth in appearance. Each cell surface had a few short microvilli. Several stomata were found near the border between the ovary and mesonephros in the posterior region of the right ovary. The size and number of stomata were variable, but tended to increase in the later stages. These findings were compared with those in the chick ovary, and a discussion is included.

Animals↗

PubMedDate not supplied

[Topography and morphometry of the porus trigeminus].

BACKGROUND AND PURPOSE: The trigeminal nerve passes from the posterior to the middle cranial fossa above the superior edge of the petrous part and below attachment of the tentorium cerebelli. Behind this place it is surrounded by the dural trigeminal cave which opens posteriorly as the porus trigeminus. The aim of this study was to describe the porus trigeminus along with its relation to the trigeminal nerve and selected structures around. MATERIAL AND METHODS: The study was performed on the material of 20 human, formalin fixed specimens of the cranial base. Measurements were taken with a surgical microscope with an ocular ruler, with precision of 0.2 mm. RESULTS: Mean width of the porus was 7.3 (+/-1.0) mm and height 2.2 (+/-0.4) mm. Dimensions of the trigeminal nerve within the porus were 5.8 (+/-0.8) mm and 2.1 (+/-0.4) mm, respectively. The porus is surrounded by shallow ellipsoid hollow measuring 12.1 (+/-1.8) over 5.1 (+/-1.1) mm. Relation of the porus to the petrous vein was described, as well as to other veins emptying to the dural sinuses in its vicinity. Distances between the porus and venous dural openings were very variable. The following distances were measured from the porus trigeminus to: the internal acustic porus [6.6 (+/-1.7) mm], jugular foramen [16.2 (+/-1.8) mm], jugular tubercle [18.9 (+/-1.8) mm], abducent nerve [5.9 (+/-1.2) mm], trochlear nerve [4.6 (+/-1.4) mm], oculomotor nerve [8.4 (+/-1.9) mm], posterior clinoid process [14.7 (+/-1.8) mm] and median plane [left 13.7 (+/-1.0), and right 13.5 (+/-1.9) mm]. CONCLUSIONS: Obtained results may be helpful during planning surgical approaches to the Meckel's cave and petroclival region.

Adult↗

PubMed2000

Restricted and shared patterns of TCR beta-chain gene expression in silicone breast implant capsules and remote sites of tissue inflammation.

Silicone breast implants (SBI) induce formation of a periprosthetic, often inflammatory, fibrovascular neo-tissue called a capsule. Histopathology of explanted capsules varies from densely fibrotic, acellular specimens to those showing intense inflammation with activated macrophages, multinucleated giant cells, and lymphocytic infiltrates. It has been proposed that capsule-infiltrating lymphocytes comprise a secondary, bystander component of an otherwise benign foreign body response in women with SBIs. In symptomatic women with SBIs, however, the relationship of capsular inflammation to inflammation in other remote tissues remains unclear. In the present study, we utilized a combination of TCR beta-chain CDR3 spectratyping and DNA sequence analysis to assess the clonal heterogeneity of T cells infiltrating SBI capsules and remote, inflammatory tissues. TCR CDR3 fragment analysis of 22 distinct beta variable (BV) gene families revealed heterogeneous patterns of T cell infiltration in patients' capsules. In some cases, however, TCR BV transcripts exhibiting restricted clonality with shared CDR3 lengths were detected in left and right SBI capsules and other inflammatory tissues. DNA sequence analysis of shared, size-restricted CDR3 fragments confirmed that certain TCR BV transcripts isolated from left and right SBI capsules and multiple, extracapsular tissues had identical amino acid sequences within the CDR3 antigen binding domain. These data suggest that shared, antigen-driven T cell responses may contribute to chronic inflammation in SBI capsules as well as systemic sites of tissue injury.

Adult↗