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[Transformation of malignant non-Hodgkin's lymphomas from low- to high-grade malignancy].

Clinical and histological findings of six patients with low grade non-Hodgkin lymphoma (NHL) which transformed to high grade tumours are reported: 5 out of the 6 cases showed transformation from the centroblastic-centrocytic type to the centroblastic-polymorphic type (Kiel classification). Clinical aggressivity, large tumour mass, high frequency of extranodal sites of disease, systemic symptoms and resistance to treatment were observed. This type of transformation is not rare, estimated to be about 20 p. 100 of cases in the literature, and is more common than Richter's syndrome in chronic lymphocytic leukaemia.

Aged↗

[Origin of malignant tumors of the upper respiratory and digestive tracts and the ear. 3. Malignant tumors caused by irradiation. general part (author's transl)].

In this part the biophysical and biochemical elements or radiation energy and the effects on tissue are discussed: 1. physical problems, 2. the cell nucleus and other cell organells as primary object of irradiation, 3. varying stages of tumor development caused by irradiation, 4. summation of radiation effects and syncarcinogenesis, 5. the stage of latency in relation to radiation-dosis and other factors, 6. immune depression caused by irradiation.

Adenosine Triphosphate↗