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An accessory flexor of the fifth toe.

The presence of accessory muscles and other organs on the lower limbs of some individuals have variously been reported in the literature. We report an unusual muscle located on the plantar surface of the left foot of a cadaver, which had not been previously described. This muscle originated from the tendon of tibialis posterior and inserted into the middle phalanx of the fifth toe. It differed from the 'expansions' of the tibialis posterior tendon, which usually pass from its insertion on the navicular bone to other tarsal bones and are ligamentous in nature. The muscle produced flexion of the fifth toe and is innervated by the medial plantar nerve. Awareness of this is important to Anatomists and surgeons, especially those working on the foot.

Cadaver↗

[Purkynje fibers of the heart conduction system--history and the present time].

It has been 160 years now since Purkynje published the finding of conduction fibers in the heart in Archiv f. Anatomie u. Physiologie and it has been 166 years since his publication in polish version. Already during Purkynje's life, some anatomists had solved the morphology of these fibers but nobody at that time knew of what great physiological and medical importance this discovery would be for medicine. It was seen as late as in the 20th century and in contemporary times. Purkynje's work indicated the cascade of these discoveries, which were leading in the beginning of the previous century to the formulation of the basic scheme of the conduction system. Purkynje fibers or Purkynje cardiomyocytes are part of the whole complex of the cardiac conduction system which today is classified as specific heart muscle tissue, being responsible for the generation of the heart impulses. From the point of view of ultrastructural composition, the cells of different parts of the cardiac conduction system are partly similar. In contrast to the heart contractile cardiomyocytes, the cells of the cardiac conduction system including Purkynje fibers have a small amount of myofibrils,small mitochondrias, light cytoplasm and a higher glycogen content, but no T-tubular system. They can be detected with some morphological methods. Nevertheless the cells of the conduction system are not completely uniform. They differ in size, number of nexuses-gaps and intercalar discs in individual parts of the conduction system. Nevertheless, these specialized cells work as a whole-unit. Nowadays, the morphology research of all the parts of cardiac conduction system, including Purkynje fibers, is focused on ultrastructural, histochemical and genetical problems. The question is, wheather with future gene/cell therapy disturbances of the conduction system such as arrythmias, can be prevented and cured by replacing the electrical pacemakers with biological ones. If Jan Evangelista Purkynje lived today, he would be surprised but surely delighted with the high degree of research concerning his discovery and its clinical application.

Animals↗

[Functional anatomy of lymphangion].

This paper reviews the results of the studies performed mainly by the Russian anatomists on the functional anatomy of lymphangion as a structural and functional unit of lymphatic vessel. One of the peculiar features of functional anatomy of lymphangion is the heterogeneity of its structures (myocytes, endothelium, blood supply and innervation). The functional heterogeneity of different lymphangions, which depends on the local differences in the combination of lymph flow factors, was demonstrated. The role of lymphatic vessels is discussed on the basis of significance of lymphangion in active lymph transport. This is demonstrated by the multiple correlations between lymphangion structure, rate and type of its contractions, length of thoracic duct lymphangions and contraction type (peristaltic, rhythmic), number of lymphangions of thoracic duct and its type (presence of collaterals), form of individual variability of thoracic duct and its myoarchitecture, body mass and lymphangion volume in various animals and at different stages of ontogenesis.

Animals↗

The comparative investigation of left ventricle papillary muscle arteries in different species.

OBJECTIVE: To determine whether similar histologic findings exist in left ventricle papillary muscle arteries in different species and to elicit whether those animal hearts may be used as models for human heart in experimental studies related to papillary muscles. METHODS: We examined 360 samples taken from the tip, mid-portion and base of papillary muscles in 60 normal adult hearts (15 each from human, dog, sheep, goat). The samples were obtained from Dicle University and Kahramanmaras Sutcu Imam University, Turkey and the study was conducted in June-September 2004. Tissues were processed by routine histologic methods, stained with hematoxylin-eosin and van giesson, and later evaluated under a light microscope. RESULTS: While the values of human and dog heart resembled each other by means of left ventricle papillary muscle arteries, the hearts of sheep and goat were also found to be similar. The number of thin walled arteries increased from the tip (18%) to the base (48%), intermediate walled arteries decreased from the tip (56%) to the base (14%), thick walled arteries decreased from the tip (62%) to the mid-portion (38%). The differences among human and animals were not statistically significant in any group. We found that the thickness values of papillary muscle arterial walls at the tip, mid-portion and base varied from 4.86 microm to 107.7 microm in all species. The difference among values of human and animals was not significant statistically (p>0.05). CONCLUSION: The values for arterial walls of tip, mid-portion and base of papillary muscles were similar between human and dog, sheep and goat. These morphologic findings in human and animal hearts of different species prove that anatomists, cardiologists, experimental investigators, pathologists and physiologists may benefit from the hearts of those animals as a good model to imitate the human heart in experiments concerning papillary muscles.

Animals↗

Knowledge-based, interactive, custom anatomical scene creation for medical education: the Biolucida system.

Few biomedical subjects of study are as resource-intensive to teach as gross anatomy. Medical education stands to benefit greatly from applications which deliver virtual representations of human anatomical structures. While many applications have been created to achieve this goal, their utility to the student is limited because of a lack of interactivity or customizability by expert authors. Here we describe the first version of the Biolucida system, which allows an expert anatomist author to create knowledge-based, customized, and fully interactive scenes and lessons for students of human macroscopic anatomy. Implemented in Java and VRML, Biolucida allows the sharing of these instructional 3D environments over the internet. The system simplifies the process of authoring immersive content while preserving its flexibility and expressivity.

Anatomy↗

An asymmetrical inferior articular process of a lumbar vertebra.

The present case report describes the topographical anatomy and radiological study of an asymmetrical inferior articular process of a lumbar vertebra, which was detected during routine osteology teaching of undergraduate medical students. The inferior articular process of the lumbar vertebra on the left side was rudimentary, while that on the right was normal in size. On the left side an additional bony projection was noted anterior to the rudimentary inferior articular process. The difference in height between the inferior articular processes of the two sides may play an important role in the kinematics of the particular joint. The orientation of the facets of the articular processes of the vertebrae are important for axial weight transmission and anomalies involving these can possibly alter the orientation of movements in that particular segment. An asymmetrical inferior articular process may be related to disc prolapse and may be a cause of back pain. In view of the paucity of research reports of anatomicoradiological study of the inferior articular process of a lumbar vertebra in relation to other parts of the vertebra, we, as anatomists, believe that knowledge of anomalies of the inferior articular process may be relevant for academic, anthropological and clinical purposes.

Cadaver↗

[Melancholy between brain and circumstances: Cabanis and the new science of man].

The period under study ends with the publication of a major work, Rapports du physique et du moral de l'homme, in which Cabanis defends the radical thesis of the identity of the physical and the moral. Amongst all the illnesses studied in this work, he accords particular importance to melancholy as it provides the best way of observing the "physical artifice of thought". Cabanis's rereading of the theses of classical medicine, which is here based on certain carefully chosen studies of the anatomists of his time, enables him to understand melancholy as both a moral affection (great sadness, exalted imagination) and a physical malfunction affecting the organs (namely the brain and the lower abdomen). He is thus able to demonstrate that it can be cured.

Brain↗

[Forgotten evidence of adrenogenital syndrome].

At present, the adrenogenital syndrome must surely be reckoned among the most widely known conditions in endocrine pathology. It may come as a surprise that no unambiguous cases of adrenogenitalism are on record before the end of the 19th century. While granting that impressive clinical descriptions may be found in isolated instances, postmortem findings are either totally missing or were not recorded in sufficient detail, thus greatly diminishing their value for retrospective study. This, however, does not apply to a case published by Luigi de Crecchio, a Naples anatomist, in 1865, of a female pseudo-hermaphrodite. De Crecchio provides, for the first time ever, a clear description of a rare pathology, underpinned by an exemplary postmortem examination, detailed clinical findings, and biographical data. Based on a complete translation of De Crecchio's article, our study comments on this almost forgotten case history, placing it, at the same time, in the context of the history of endocrine research.

Adrenogenital Syndrome↗

A retrotracheal right subclavian artery in association with a vertebral artery and thyroidea ima.

The retro-oesophageal right subclavian artery is an anatomical abnormality encountered by anatomists and pathologists and, more recently, interventional cardiologists and thoracic surgeons with an incidence of 0.2-2% in the population. We report a case of a retrotracheal right subclavian artery which originated distally along the left aortic arch and coursed between the trachea and the oesophagus. Additionally, the aortic arch gave rise to a common trunk, which subsequently bifurcated to yield to a right vertebral artery and a left thyroidea ima, replacing the left inferior thyroid artery. Consequently the right and the left recurrent laryngeal nerves were found to recur normally. The possible embryonic development of these branching patterns and their clinical significance is discussed.

Aorta, Thoracic↗

In-vivo endoscopic visualization of patho-anatomy in painful degenerative conditions of the lumbar spine.

The degenerative processes in an aging spine have been defined traditionally only by our knowledge of the biology of disc and facet degeneration, as well as interpretation of post-mortem cryosections by forensic anatomist Wolfgang Rauschning, M.D. In this chapter, visualization of in-vivo patho-anatomy in a degenerating disc and spinal segment is demonstrated at surgery using the Yeung Endoscopic Spine System (Y.E.S.S.), (Richard Wolf Surgical Instrument Company, Vernon Hills, IL, USA). An Institutional Review Board (IRB)-approved study of endoscopic treatment for degenerative conditions of the lumbar spine incorporated intraoperative probing under local anesthesia and endoscopic treatment of the visualized patho-anatomy. An intraoperative evocative chromo-discogram, using indigocarmine, was used to elicit discogenic pain and label the fissured and degenerative nucleus pulposus for surgical removal and thermal modulation. Painful patho-anatomy was probed in a conscious patient. The most common endoscopic finding was Inflammatory tissue in the disc and annulus. Inflammation was correlated with the presence of annular tears. Patho-physiologic changes that affect the exiting nerve, which contains the Dorsal Root Ganglion (DRG), was associated with stenotic and chemical irritation. Unavoidable postoperative dysesthesia was associated with the presence of an inflammatory membrane, and removal or thermal coagulation of "anomalous" furcal nerves in the foramen that branched off of the exiting spinal nerve. Neo-angiogenesis and neurogenesis in the inflammatory membrane present in the foraminal triangle was a new finding not reported in traditional clinical studies. Visualization and treatment of pathologic findings inside (annular tears) and outside the disc in Herniated Nucleus Pulposus (HNP), synovial cysts, foraminal stenosis, central stenosis, spondylolisthesis, is demonstrated. The endoscopic foraminal approach to the spine and disc is a technique that provides access to patho-anatomy in the lumbar spine not usually feasible with traditional surgical methods. Favorable surgical results allow for continued evolution of the endoscopic method, concomitant with the continued evolution of endoscopic spinal surgery.

Back Pain↗

[Leonardo Botallo, de via sanguinis].

The article deals with the work of the seventeenth century anatomist Cecilio Folli who, between 1639 and 1645, republished a treatise by L. Botallo on the foramen ovale. Both Folli and Botallo, following Aristotelian philosophy, advocated the thesis that this anatomical structure did not disappear in adults.

Blood Physiological Phenomena↗

High origin of a superficial ulnar artery arising from the axillary artery: anatomy, embryology, clinical significance and a review of the literature.

The superficial ulnar artery (SUA) is an ulnar artery of high origin that lies superficially in the forearm. Its reported frequency ranges from 0.17% to 2%. During anatomical dissection in our department we observed a unilateral case of SUA in a 75-year-old white male human cadaver. It originated from the right axillary artery at the level of the junction of the two median nerve roots and followed a looping course, crossing over the lateral root of the median nerve and running lateral to it in the upper and middle thirds of the arm, whereas in the inferior third of the arm the SUA crossed over the median nerve and ran medially to it. In the cubital fossa, it passed superficially over the medial side of the ulnar aponeurosis and coursed subcutaneously in the ulnar side of the forearm superficially to the forearm flexor muscles. In the hand the SUA anastomosed with the superficial palmar branch of the radial artery, creating the superficial palmar arch. Additionally, it participated in the development of the deep palmar arch. The axillary artery, after the origin of the SUA, continued as the brachial artery and divided into the radial and common interosseous arteries in the cubital fossa. The normal ulnar artery was absent. No muscular or other arterial variations were observed in this cadaver. The embryological interpretation of this variation is difficult and it may arise as a result of modifications to the normal pattern of capillary vessel maintenance and regression. The existence of a SUA is undoubtedly of interest to the clinician as well as to the anatomist. This report presents a case of unilateral SUA along with a review of the literature, embryological explanation and analysis of its clinical significance.

Aged↗

[The origin of the arteria sigmoidea ima].

The authors report the results of their observations on the lowest sigmoid artery, carried out on 92 anatomical specimens coming from surgical operations on the sigmoid and rectum. The specimens were injected and radiographed immediately after their removal . The observations were often preceded by pre-operative angiographies performed for diagnostic reasons. The AA. document all the variational patterns of this artery. They confirm the poor functional value of this artery more known by the old surgeons than by the anatomists.

Angiography↗

[The vallecula: an anatomic reality?].

The vallecula epiglottica is a borderline area between the pharynx and the larynx, though covered by the epiglottis, and a functionally strategic site and breeding ground for epidermoid carcinoma, but it has remained unappreciated by anatomists. The borders of the vallecula within the oropharynx are represented by the anchoring systems of the epiglottic cartilage; the basilingual margin is sometimes inaccurate. We would like to emphasize the topographical relationships in the vallecular region, in particular: --the proximity to the base of the tongue, which is the preferred are of extension of epitheliomas, --and the features of the hyoepiglottic membrane, which is a veritable barrier for neoplastic infiltration. The valleculae epiglotticae are a definite oropharyngeal anatomical entity, and deserve the attention of maxillofacial surgeons, who should be able to suggest a surgical treatment of cancers that would be practicable both from a functional and from an oncological point of view.

Epiglottis↗

[Carl Ludwig Homburg. A prosector in Goethe's time].

The interest of the medical historian is not necessarily confined to great scholars but can be devoted, as well, to assistant like Homburg who had been not only the prosector of J. C. Loder, anatomist in Jena but had, at the same time, worked for J. W. v. Goethe, Cabinet Minister in Weimar and in charge of Jena University. Some data on the life of prosector C.L. Homburg (who died in 1833) are known to us from notes and letters of Goethe and Loder. Loder had employed the former Berlin student of surgery and barber's assistant to model for him anatomic samples for demonstration and anatomic illustrations and also for his collection. When Loder followed a call to Halle and took his collection of specimens along with him, his successor in Jena had to set up another collection which came under ducal administration. Homburg gave him a helping hand, under Goethe's vigilant control. Loder sold his collection to Russia, some time later, and had an Anatomic Theatre built in Moscow for its accommodation and for anatomic lectures. For that purpose, he called Homburg from Jena and praised him in his public inauguration speech. Two sons and one grandson of Homburg are known to have worked as prosectors, as well, in Moscow, Kharkov, and Kazan.

Anatomy↗

Anatomy of the thorax and shoulder girdle displayed by magnetic resonance imaging.

In 1971, radiographic anatomy of the human body was added to the gross anatomy course at UCLA. Radiographic contrast studies and plain anatomical displays were formulated into teaching packages for all organ systems. Residents presented each package to first-year medical students in the dissection laboratory to augment the teaching of anatomy. In November 1984, magnetic resonance imaging was instituted in the radiology department. Imaging the chest produced coronal and axial planes which displayed the muscles and soft tissues of the thorax. In 1986, the authors presented their study of MR anatomy of the chest and shoulder girdle to the American Association of Anatomists. The purpose of this presentation is to demonstrate the anatomy of the thorax and shoulder girdle as displayed by magnetic resonance, correlated with regional anatomy, with emphasis on soft tissue structures.

Humans↗

[Automatic equipment for injections of anatomic specimens with plastic masses].

The paper presents the description of the automatic devices for injections of anatomic preparations of the author's own construction. Subunits of the device, that is compressed air distribution control device and the anatomic preparations injection syringe were given the patterns protection law and copyright in Patent Office in Poland. The application of appropriately chosen pressure reduction valves of two operational ranges, makes it possible to determine the pressure head of the air pushing injection mass out of the syringe and to adjust it precisely in the range 1-100 kPa. The constructed injection device is reliable in operation and easy in service. It has already been rendered accessible to several angiological laboratories in Poland. The opinion given by the anatomists using this device is very favourable.

Air Pressure↗