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Analogue computation of indices of contraction from regional measurements in intact hearts.

Computation of indices of regional myocardial contractility such as the shortening, or the work done by or on a segment of myocardium in a single cardial cycle is tedious to perform manually, and complex interfacing and software is needed for digital computation. We describe the principles of an on-line, analogue device to perform these computations . The accuracy of the machine is demonstrated, and examples of the uses of the devices are given.

Animals↗

Current status of the motor program.

Motor program theory has provided physical therapists with one approach to understanding how the brain controls movement. Analogous with computer programs that specify the operations of computer hardware, motor programs are thought to contain commands for muscles that allow movements to occur without the need for continuous peripheral feedback. A review of the physical therapy literature reveals many instances in which motor program theory has been used as a theoretical framework for clinical practice. Yet despite the contribution programming theory has made to the advancement of movement science, the motor program construct is currently under considerable threat. Keele's (1968) original definition no longer seems tenable, given the problems of program storage, motor equivalence, movement flexibility, and context-conditioned variability. The finding that researchers from different disciplines define the motor program in a variety of ways adds difficulty to the task of evaluating the efficacy of the model. A critical appraisal of programming theory and its use in physical therapy suggests that clinicians need to reconsider the usefulness of the motor program model as a basis for movement rehabilitation following brain damage and musculoskeletal disorders.

Humans↗

Renal uptake of Tl-201 in hypertensive patients undergoing myocardial perfusion imaging.

The detection of renovascular disease (RVD) has particular relevance in hypertensive patients (HP) who have symptoms of target organ damage. To evaluate the possibility of RVD in HP undergoing myocardial perfusion scintigraphy for chest pain symptoms, posterior renal images were obtained at 1-3 hours after Tl-201 injection. Analog and computer images were obtained for 5 minutes in 45 HP; 12 patients with no history of hypertension or renal disease served as normal controls. For qualitative analysis, images were coded and read by three observers as to symmetry of renal uptake. Differential renal uptake of Tl-201 (DRU) was quantitated on computer images. In normal controls, uptake was agreed on as symmetric. In HP, 6 patients had marked asymmetry of DRU and 4 had possibly significant asymmetry; 2 had decreased uptake in both kidneys suggesting bilateral RVD or nephrosclerosis. Objective correlation with DRU was obtained in 10 HP who had contrast angiography, confirming 4 cases of unilateral RVD and 2 of bilateral RVD. Thirteen patients also had renography with Tc-99m DTPA; differential renal function by this modality correlated well with DRU of Tl-201 (r = 0.98). Thus, DRU of Tl-201 can be used as a supplement to myocardial scintigraphy to identify HP who require further evaluation and treatment of RVD.

Adult↗