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Medical schools and their applicants: an analysis.

Shortages of physicians have existed periodically throughout U.S. history. In response, medical school capacity has been increased, by either building new schools or expanding existing ones. Each strategy has encountered the obstacles of time, money, and applicants. If the United States chooses to increase its infrastructure for medical education again, these past experiences offer lessons that can be drawn upon. The most instructive ones are how long this process will take, how important public sponsorship and financing will be, and how much it will depend on antecedent dynamics within K-12 and baccalaureate education to assure an adequate flow of applicants, all of which makes the need to develop strategies for the future ever more pressing.

Cultural Diversity↗

Physical activity in modern industry.

The research carried out in order to estimate the physical effort under the present circumstances of the industrial technological development have pointed out that most of the activities in the heavy industry branches are now carried on within the frame of medium load. An evident trend was found of extending the activities implying light work in mechanized mining, automatic glass-processing, thermo-power stations, but tasks requiring high energy cost are still in forestry, mining, building. Significant differences in the physical capacity related to the level of occupational physical load have been revealed. Experimental working regimens as well as programmes of gynmastics during the breaks of the shift in activities of lower physical effort proved to have a beneficial effect on performance, on work capacity and fatigue prevention. Maximum permissible duration of loads carried by women and factors of stress were also assessed in occupational activities where women are employed in increasing number. The present problems of physical activity in industry require further research into: more detailed aspects connected with the increase of static effort, effect of physically active recreation, methods for improving physical capacity. Further studies are also expected to assess and evaluate physical effort in new occupations.

Energy Metabolism↗

[Effect of continuous gamma-radiation at low doses on clonogenic hemopoietic (CFU-S) and stromal (CFU-F) bone marrow cells ].

We studied the effects of low doses of continuous gamma-irradiation (Co60, 10 days, mean daily dose power 1.5-2.0 mGy, total dose 15 mGy) on hemopoietic and stromal progenitor cells of murine bone marrow. The content of hemopoietic clonogenic cells representing a "younger" (CFU-S-11) and more "mature" (CFU-S-7) categories in the compartment of stem cells was determined in the bone marrow. The state of bone marrow stroma was estimated by the method of in vitro cloning according to the number of progenitor cells that form colonies of fibroblasts (CFU-F) and by the method of ectopic transplantation according to the capacity of stroma of organizing and building new hemopoietic territories. Continuous gamma-irradiation at low doses, that were by one order of magnitude lower than those inducing hermesis, exerted a stimulating effect on both hemopoietic (CFU-S) and stromal (CFU-F) progenitor cells. The number of CFU-S in the compartment of stem cells of the bone marrow markedly increased and they formed larger hemopoietic territories but these cells appeared to create a qualitatively different microenvironment, which stimulated the proliferation of CFU-S.

Animals↗

HIV/sexual and reproductive health program for HIV prevention: the youth-adult partnership with schools approach.

The aim of the present study was to describe the development and evaluation of a program designed to prevent HIV/AIDS. A participatory action research (PAR) approach was used in collaboration with ten schools in Chiang Mai Province, Thailand, to develop a youth- adult partnership with schools (YAPS) model. The YAPS model included curricula using participatory learning experiences, edutainment approaches, and skills building strategies for enhancing youth leaders'capacities. Results showed that the YAPS model was effective in leadership role preparation and in empowering youth leaders to undertake activities on their own, initiate creativity and share knowledge on sexuality education and HIV prevention messages with students in schools. The use of partnerships and the participatory process mobilized parents, teachers, and school administrators to play a proactive role in sexuality education and HIV prevention for early adolescents in schools, resulting in the integration of the program into the school system.

Adolescent↗

Response of bone marrow stroma cells to demineralized cortical bone matrix in experimental spinal fusion in rabbits.

The effect of autogeneic bone marrow (BM) cells and allogeneic demineralized bone matrix (DBM), alone or combined, as transplantation materials was studied in an experimental posterior thoracic spinal fusion model in rabbits. Transplantation of composite grafts composed of BM and DBM showed the first signs of fusion between two spinal segments after four weeks, reaching 86% after 20 weeks. Late fusion results achieved with DBM alone were similar. The capacity of BM per se to build up a spinal fusion was insignificant. Calcified tissue, documented roentgenographically, was shown to develop locally with time, and the earliest bridging of an interspace was noted after four weeks. Histologically, formation of new bone and cartilage was observed after two weeks, showing mature lamellar bone formation between thoracic segments after 20 weeks. Furthermore, increased 45Ca activity was still observed in the fused tissues after 20 weeks. Although, with grafting materials used, this model for experimental spinal fusion gave promising results, further investigations with other fusion techniques could give still better effects.

Animals↗

The evolution of fetal and infant mortality review as a public health strategy.

Infant mortality review (IMR), the forerunner of fetal and infant mortality review (FIMR), emerged at the national level in the mid-1980s as a promising method to improve understanding of local factors contributing to infant mortality and to motivate community response. Building on federal efforts to enhance data capacity and early state and local infant mortality case review studies, the federal Maternal and Child Health Bureau (MCHB) initiated its IMR Program in 1988. Key actions taken to refine and diffuse the IMR/FIMR method include forging a public-private partnership between MCHB and the American College of Obstetricians and Gynecologists in 1990 to develop the National Fetal and Infant Mortality Review Program, recruiting prominent leaders to advocate for FIMR, seeding community projects in geographically dispersed states and localities, and routinely reporting best practices information to the field. In concert with the articulation of core public health functions and a growing emphasis on accountability, attention at the national level has turned to promoting and institutionalizing FIMR in state systems. Efforts are underway in states to build on the FIMR model and coordinate multiple maternal and child health-related review programs. Increasingly, FIMR is recognized as a strategy for contributing to implementation of the core public health functions of assessment, policy development, and quality assurance. The recent national evaluation of FIMR sheds new light on the role of FIMR in community and state maternal and child health systems and marks a new phase in the evolution of FIMR.

Child Health Services↗

"Health is strength": a research collaboration involving Korean Americans in Alameda County.

INTRODUCTION: This is a preliminary report from a research collaboration between Asian Health Services (community health center); Koreans in Alameda County, California; and the University of California at Berkeley School of Public Health. This five-year Centers for Disease Control and Prevention project supports a collaborative community intervention to improve breast and cervical cancer screening behavior among Korean women. METHODS: A Korean Community Advisory Board and Korean-American staff were recruited, and community sensitive research (CSR) and participatory action research (PAR) principles were applied: (1) building community infrastructure for sustainable action, (2) cultural appropriateness, (3) assuring responsiveness to community needs, and (4) a prevention focus that would assist health care providers. We conducted a population-based telephone survey on 676 Korean adults (272 men and 404 women). RESULTS: The collaborative process yielded (1) a high response rate (79%), (2) baseline health information on Korean Americans, (3) broadening of the original research topic, (4) survey responses that will guide intervention design, (5) culturally competent strategies, and (6) expanded Korean-American Community capacity for local action. CONCLUSIONS: Research collaboration between universities, community-based organizations, and ethnic communities can yield high-quality research. CSR and PAR approaches help break through cultural barriers in otherwise "hard to reach" API sub-populations. Determinants of success include sharing common goals; trust, honesty, and integrity; shared decision making; mutual respect of each partner's expertise; cultural sensitivity and cultural competence; flexibility, good communication, and mutual learning; and continuity of partners. Actively engaging members of the study population in the research process builds community capacity, thus laying the foundation for future projects that improve health status.

Adult↗

Capacity and demand models for radiotherapy treatment machines.

Models to predict the number of linear accelerators (linacs) required usually assume that capacity needs to equal demand. Queuing theory shows that capacity needs to exceed mean demand, to avoid the build-up of waiting times. A model has been developed, using Monte-Carlo modelling, to calculate the percentage of spare capacity required to keep waiting times to treatment short. For a matched pair of linacs, in a department that closes on bank holidays and compensates for category 1 patients by treating twice before or after the break, about 10% spare capacity is required to ensure that 86% of patients are able to start radiotherapy within a week of completing the treatment planning process. If a machine is booked as a single (unmatched machine), an additional 3% spare capacity is needed. If all bank holidays in the year are worked, then about 3% less is needed.

Algorithms↗

Integrating international responses to complex emergencies, unconventional war, and terrorism.

The world is experiencing unprecedented violence and threats of violence, taking the form of complex internal nation-state conflicts, unconventional or guerrilla warfare against established governments, and stateless threats of terrorism by potential biologic, chemical, and nuclear weapons. What happens locally has immediate ramifications internationally. Real and potential health consequences of these events have evoked global concerns and realization that capacities and capabilities to respond to such events require unparalleled integration, coordination, and cooperation of the international community. However, politics and the institutions singular governments form are inherently limited in their objectives and capability to effectively respond. Public health, broadly defined, must be recognized as a security and strategic requirement, one that serves to build a foundation for an international integrated response capacity.

Disaster Planning↗

Heavy-metal-ion capture, ion-exchange, and exceptional acid stability of the open-framework chalcogenide (NH(4))(4)In(12)Se(20).

The hydrothermal synthesis of the purely inorganic open-framework indium selenide (NH(4))(4)In(12)Se(20) (1) is reported. Compound 1 exhibits a unique three-dimensional open-framework structure. The framework of 1 shows an unusual, for a chalcogenide compound, rigidity arising from the unprecedented connection mode of its building blocks. Compound 1 possesses ion exchange capacity for Cs(+), Rb(+), NH(4) (+), but it has selectivity against Na(+) and Li(+). It also showed exceptional stability in relatively concentrated hydrochloric acid. Ion exchange of 1 with hydrochloric water solutions can produce its solid acid analogue H(2)(NH(4))(2)In(12)Se(20). The maximum cation-exchange capacity of 1 was found equal to two equivalents per mol, which is consistent with an exchange mechanism taking place in the 1D-channels formed by the largest cavities. In addition, 1 can do ion-exchange with heavy-metal ions like Hg(2+), Pb(2+), and Ag(+). The capacity of 1 to clean water solutions from heavy-metal ions was preliminarily investigated and found very high. Specifically, 1 can remove 99.9 % of Hg(2+), 99.8 % of Ag(+), and 94.9 % of Pb(2+) from aqueous solutions of each of these ions. Using different synthetic conditions, we isolated compound (NH(4))(2)In(12)Se(19) (2), which also has as good an acid stability as 1, but no ion-exchange properties. Overall, this work provides new hydrothermal synthetic approaches for isolation of all-inorganic open-framework chalcogenides.

Journal Article↗

Learning from communities: overcoming difficulties in dissemination of prevention and promotion efforts.

The model of prevention science advocated by the Institute of Medicine (P. J. Mrazek & R. J. Haggerty, 1994) has not lead to widespread adoption of prevention and promotion programs for four reasons. The model of dissemination of programs to communities fails to consider community and organizational capacity to implement programs, ignores the need for congruence in values between programs and host sites, displays a pro-innovation bias that undervalues indigenous practices, and assumes a simplistic model of how community organizations adopt innovations. To address these faults, researchers should locate, study, and help disseminate successful indigenous programs that fit community capacity and values. In addition, they should build on theoretical models of how locally developed programs work to make existing programs and polices more effective.

Community Mental Health Services↗

William Beaumont Hospital Imaging Center design update.

The William Beaumont Imaging Center is designed to bridge the gap between conventional and totally digital imaging technology. Reverse capacity and flexibility are designed into the building and it's systems to facilitate the transition at minimal cost and disruption to daily operations.

Diagnostic Imaging↗

Temporal and spatial distributions of aerial contaminants in an enclosed pig building in winter.

Optimal management of indoor air quality in an enclosed swine house, especially in winter, is indispensable for preventing the transmission of infectious respiratory disease to workers and animals. Studies are needed to elucidate the correlation of aerial contaminants and climate factors. It was observed that indoor air contamination in an enclosed pig building was the highest at 2:00--5:00 PM, followed by 8:00--11:00 PM and 8:00--11:00 AM. It was assumed that this was attributed to the increase of swine activities in the afternoon. In general, the concentration of total dust and total airborne bacteria in an enclosed pig building was found to have a significant correlation with temperature and relative humidity (P<0.05). There were significant correlations between total dust and total airborne bacteria, between total dust and ammonia, and between total dust and odor at the 95% confidence level. In conclusion, temperature and total dust concentration correlated significantly with all parameters except hydrogen sulfide (H(2)S). This could have been due to the drying of swine feces due to the increase in interior temperature and the resuspension of feed deposited on the floor of the pig building by the swines' activity, resulting in a high generation of dust that adsorbed and carried the airborne bacteria and odorous compounds in the enclosed pig building. It was proved that an adsorptive capacity of dust for ammonia was higher than for hydrogen sulfide.

Air Microbiology↗

Construction of biologically active protein molecular architecture using self-assembling peptide-amphiphiles.

The peptide-amphiphiles described here provide a simple approach for building stable protein structural motifs using peptide head groups. One of the most intriguing features of this system is the possible formation of stable lipid films on solid substrates, or the use of the novel amphiphiles in bilayer membrane systems, where the lipid tail serves not only as a peptide structure-inducing agent but also as an anchor of the functional head group in the lipid assembly. The peptide-amphiphile system potentially offers great versatility with regard to head and tail group composition and overall geometries and macromolecular structures. For building materials with molecular and cellular recognition capacity, it is essential to have a wide repertoire of tools to produce characteristic supersecondary structures at surfaces and interfaces.

Drug Design↗