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PubMed1976

[Investigations of the lipase activity of a pancreatin compound (author's transl)].

In connection with the physiologic process of digestion, the requirements for an enzyme-based drug are stated. Quick release of highly active enzymes in the duodenum is a prerequisite of physiological stimulation of the pancreatic excretory function. Digestive potency is regarded as a suitable gauge for comparing of results in large-scale in vitro scanning. Our own in vitro and in vivo studies have borne out the possibility of transferring in vitro findings to the therapeutic value of this compound. As shown by our investigations, quick release of highly active enzymes in vitro is coupled with a high degree of bioavailability in Fermento duodenal. As a result, normalization or reduction of the lipid content of faeces--as a sign of therapeutic efficacy--is seen in patients with pancreatic excretory insufficiency. Statistical evaluation resulted in the following: 1 A statistically significant (p less than 0.1%) increase in lipase activity in the duodenal juice in vitro after addition of one capsule of Fermento duodenal. 2. Lipase activity in vivo after 15 minutes is significantly different from all other values. 3. A statistically significant (p less than 1%) drop in the amount and lipid content of faeces following the treatment with Fermento duodenal.

Adult↗
PubMed1977

[Gastric emptying].

Gastric emptying can be measured by three basically different means: Intubation -x-ray - Isotopes, X-ray methods may be neglected as they do not permit quantitative measurement of the exptying process. Intubation methods offer the advantage of exact determinations of emptying rates, but disadvantages are the limitation to liquid meals and patient discomfort. Radioisotopes can be used as marker both of liquid and solid foodstuffs with minimal patient discomfort. However problems often neglected wtih isotopes are reliability of their attachement to the marked meal and radiation dose to the probands. The most important indications of measuring gastric emptying is determination of alterations induced by peptic ulcer surgery and drugs.

Chromium Radioisotopes↗
PubMed1976

The different components of gastric emptying after gastric surgery.

Gastric emptying of liquid and solid meals was studied before and after operation in 22 male patients who were admitted to a prospective randomized trial of truncal vagotomy and antrectomy and proximal gastric vagotomy in the treatment of duodenal ulceration. After operation the emptying of both solid and liquid meals was biphasic, with a passive early phase and a later controlled active phase. A significant increase in early liquid emptying was produced by both operations, and after truncal vagotomy and antrectomy also with the solid meal. Active emptying of the liquid meals was unaffected by either operation, but both operations significantly prolonged the active emptying of the solid meals. The clinical symptoms of dumping were related to rapid early liquid emptying (cascading) and those of gastric retention were related to delayed active emptying of the solid meal. These findings explain how the same operation can produce the opposing symptom complexes of dumping and gastric retention and how both sets of symptoms can occur in the same individual.

Constipation↗