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[Psychopharmacotherapy in pregnancy and lactation. 2: Lactation].

Whilst the incidence of psychiatric disorders decreases during pregnancy, the risk during the postpartum period increases significantly, often leading to the necessity of psychopharmacological intervention during the puerperium, and subsequently during lactation and breast-feeding. The necessity for lithium prophylaxis in manic-depressive women after childbirth has been identified, and it is recommended that weaning rather than omission of psychopharmacological treatment is preferable during the puerperium.

Female↗

Women at risk for postpartum-onset major depression.

There is considerable evidence that the childbearing years represent a time when women are highly vulnerable to developing mood disorders. Prospective, cross-sectional, and retrospective studies have demonstrated that more than 10% of new adult mothers will experience a major depressive episode during the first postpartum year. Changes in the health care delivery system will result in increased pressure on the obstetrician/gynecologist to identify and treat women with postpartum-onset depression. Despite shortcomings in the available literature, prospective studies have identified risk factors for developing postpartum depression. Furthermore, the clear overlap between the normal sequelae of childbirth and the symptoms of major depression, including alterations in sleep, energy, libido, appetite, and body weight, underscores the need to develop guidelines for early identification. We furnish a brief overview of postpartum mood disorders with a primary focus on the antenatal and postnatal risk factors for developing postpartum depression. Based on the extent literature and our clinical experience, a set of recommendations for early identification and treatment is provided.

Depressive Disorder↗

Rat brain hypothalamic and hippocampal monoamine and hippocampal beta-adrenergic receptor changes during pregnancy.

The concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decreased and their turnover increased relative to postpartum and estrous values, respectively. Hippocampal 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels were significantly decreased at 15 days of pregnancy and 4 days postpartum compared to estrous and 20-day pregnant levels and the MHPG/NA ratio was significantly reduced at 4 days postpartum relative to the estrous value. Hippocampal 5-HT and 5-hydroxyindole-3-acetic acid (5-HIAA) levels were significantly decreased at 15 days of pregnancy while 5-HIAA levels and the 5-HIAA/5-HT ratio were significantly decreased at 20 days of pregnancy. Hippocampal beta-adrenergic receptor density was significantly lower at 4 days postpartum than at 15 days of pregnancy. A positive correlation was observed between plasma progesterone and hippocampal beta-adrenoceptor Kd values, suggesting a possible causal relationship between these two variables. The monoamine and beta-adrenoceptor changes which occur during pregnancy may be an important contributing factor in determining the mood changes which occur during pregnancy and postpartum.

Animals↗

Sleep deprivation and the postnatal blues.

This prospective study of 63 women was designed to investigate the relationship between sleep disruption prior to the birth, during labour and in the early postpartum period and the subsequent development of the postnatal blues. The results from this preliminary study suggest that two factors: (a) a night-time labour; and (b) a history of sleep disruption in the latter stages of pregnancy, may have aetiological importance in the development of postnatal blues. There was little evidence from this study to suggest that sleep disruption on the nights following the birth, the third sleep factor investigated, had any impact on the expression of the blues.

Adult↗

Pharmacologic treatment of psychiatric disease in pregnancy and lactation: fetal and neonatal effects.

OBJECTIVE: To review published data pertaining to safety of psychoactive drugs used to treat psychiatric disorders during pregnancy and lactation. DATA SOURCES: A computerized search of articles published through July 1995 was performed on the MEDLINE data base. Additional sources were identified through cross-referencing. METHODS OF STUDY SELECTION: All identified references were reviewed with particular attention given to study design. DATA EXTRACTION AND SYNTHESIS: Each reference was reviewed to determine the safety of psychoactive agents to treat depression, bipolar disease, schizophrenia, and anxiety during pregnancy and lactation. Prospective or large retrospective studies were given more importance than case reports. CONCLUSION: Psychoactive medications may be used during pregnancy. Because data on safety are largely retrospective, treatment decisions must be weighed carefully.

Abnormalities, Drug-Induced↗

An overview of somatic treatment of psychosis during pregnancy and postpartum.

Treatment and management of the psychotic pregnant patient is insufficiently covered by most standard texts and the current literature. To date, there are no controlled studies on the efficacy of different therapeutic modalities during pregnancy. Medications that have proved effective in the treatment of the various psychoses are not without added risk for the pregnant patient. However, there is no effective medical treatment without attendant risk. Although the psychotic pregnant patient presents a therapeutic dilemma, these patients can be effectively treated by a program that allows for flexibility and innovation within the framework of sound conservative medical practice. Professional territorial difficulties can be avoided by a unified effort.

Abnormalities, Drug-Induced↗

A concept analysis of panic.

Minimal attention has been focused on the concept of panic in the discipline of nursing. Hindering a greater understanding of panic is its lack of explication and development in nursing. To help remedy this situation, a concept analysis of panic was performed. The hybrid model of concept development was used, which consists of an initial theoretical phase, a fieldwork phase, and a final analytical phase. In the theoretical phase, after a cross-disciplinary literature search was done, existing definitions and measurement of the concept of panic were analyzed, and a working definition of panic was formulated. In the fieldwork phase, women experiencing postpartum panic disorder were interviewed to collect qualitative data for further analysis of panic. The final phase focused on comparing and contrasting the findings from the theoretical phase with the insights discovered from the fieldwork. Applicability of panic across nursing is addressed along with implications for nursing theory, practice, and research.

Anxiety↗