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Results for “Electrocoagulation”

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At least 1,063 records · Page 59Linked to original sources

PubMed2005

[The expression of heat shock protein 27 in retinal ganglion cells in the rat glaucoma model].

OBJECTIVE: To observe the expression of heat shock protein 27 (HSP27) in retinal ganglion cells in experimental rat glaucoma model and to study the relationship between HSP27 expression and hypertension using serum autoantibodies. METHODS: Forty nine Wistar rats were randomly divided into ocular hypertension group, sham control group and normal control group. Intraocular pressure (IOP) was elevated by electrocoagulation of at least 3 episcleral and limbal veins in the right eye of each rat. Contralateral eyes were used as the controls. Serum immunoreactivity against HSP27 was examined in these three groups by means of enzyme-linked immunosorbent assay (ELISA). Immunohistochemical staining for HSP27 was performed in 49 rats (98 eyes) for studying the distribution of the target gene products in retinal ganglion cells and retinal nerve fiber layer. RESULTS: Electrocoagulation treatment caused a significant increase of IOP and was maintained for 8 weeks (P < 0.01), which was greater than that in the contralateral eyes, sham control eyes and normal eyes. The baseline IOP was (15.69 +/- 3.20) mm Hg (1 mm Hg = 0.133 kPa). IOP was increased to (27.52 +/- 6.63) mm Hg (3 days after the operation), (31.42 +/- 6.18) mm Hg (1 week after the operation) and stabilized thereafter for 8 weeks. Serum ELISA titers of HSP27 antibody were higher in ocular hypertension group as compared to the control groups in both sham and normal group at 2 weeks after operation (P < 0.01) and 3 weeks after operation (P < 0.05). The expression of HSP27 was significantly enhanced in RGCs with IOP elevated and sustained. It was also significantly increased in retinal nerve fiber layers (RNFL). CONCLUSION: Enhanced expression of endogenous HSP27 might play an important role in the development of glaucomatous optic neuropathy.

Animals↗

PubMed1991

[Villous polyp of the urethra].

Villous polyps of the urethra are rare. This condition can be seen more frequently in patients aged 30-40 years. Hematuria is usually the major symptom. Generally, the polyps are localized in or around the verumontanum and do not recur after TUR or electrocoagulation. A case of villous polyp of the verumontanum is described in a patient who presented with symptoms and signs of obstructive micturition. The patient continues to be asymptomatic 6 months following treatment by electrocoagulation.

Humans↗

PubMed1989

Vulvo-vaginal condylomatosis and relapse: combined treatment with electrocauterization and beta-interferon.

The therapeutical effectiveness of beta-interferon and the possibility of reducing the incidence of relapses were evaluated by selecting three groups of patients affected with three forms of condylomatosis and submitting then to various treatments. In the first group of sixty patients treated with beta-interferon, we obtained the best results in micro-condylomatosis (a 100% response), while florid condylomatosis responded less well to the treatment (72% with no response). In the second group of ten patients, electrocoagulation of florid condylomata determined a complete response (CR) in seven cases (70%). Moreover, immunoperoxidase identified three case of sub-clinical infection, two of which relapsed. In the third group of ten patients, we combined electrocoagulation with beta-interferon. This combination showed the effectiveness of beta-interferon in decreasing relapses. This result is evident if we consider that only one out of four patients with immunoperoxidase-positive biopsy relapsed.

Adolescent↗

PubMed1979

[Effect of commonly practiced manoeuvres in vascular microsurgery. Study under the scanning electron microscope (author's transl)].

The authors studied in 100 Wistar rats the manoeuvres that may commonly be carried out during vascular microanastomosis of diameter less than 3 mm (aorta and posterior vena cava): clamping for 30 to 45 minutes, bipolar electrocoagulation of the collateral arteries, more or less marked pinching of the vascular wall. The risk of thrombosis seems all the greater when: --the surgeon is inexperienced: viz. trauma with the forceps, parietal tears at the level of the stitches, two many threads passed for hemostasis (all these factors accentuate the fibrinoid and platelet deposits); --bipolar electrocoagulation of a collateral artery applied too close to the vessel to be anastomosed (less than 1 mm.)The formation of a smooth and regular fibrinous pseudo-intima appears within 48 to 72 hours which may explain the elective onset of thromboses before this delay.

Animals↗

PubMed1979

Luteal deficiency among women with normal menstrual cycles, requesting reversal of tubal sterilization.

Forty women with normal menstrual cycles who had been sterilized by tubal ligation or electrocoagulation requested tubal reconstruction. As part of their preoperative evaluation, progesterone measurements were obtained in the midluteal phase (5-10 days before the next menstrual period). This group of women had a significantly lower (P less than 0.005) mean midluteal progesterone level (9.4 +/- 4.7 ng/ml) than a control group of 24 women with infertile male partners attending the same clinic (17.4 +/- 7.1 ng/ml). In 25 (62%) of the sterilized women, progesterone levels were less than 10 ng/ml, whereas in the control group such low values were found in only 4 (17%) of the women. Thus, reduced midluteal serum progesterone concentration appears more common among women with prior tubal ligation or electrocoagulation than among a control population of apparently normal women.

Adult↗

PubMed1980

[Influence of the pars intercerebralis and of median sub-ocellar neurosecretory cells on the concentration of vasopressin-like substance in the ventral nerve cord and haemolymph of Locusta migratoria (Orthoptera). Radioimmunoassay and immunohistology (author's transl)].

1 degree In the migratory locust, electrocoagulation of the neurosecretory cells of the pars intercerebralis increases the rate of water elimination, while electrocoagulation of the median sub-ocellar neurosecretory cells elicits a marked water retention. 2 degrees In the first type of experiment, high concentrations of molecules antigenically close to vasopressin can be measured by RIA in the haemolymph; such molecules are practically undetectable in the blood when median sub-ocellar neurosecretory cells are suppressed. 3 degrees Our data lead us to assume that the vasopressin-like molecules detected in the migratory locust promote water elimination.

Animals↗

PubMedDate not supplied

Comparison of different methods of treating varicocele.

Varicocele treatment was performed in 331 patients. One hundred fifteen patients were operated upon according to the technique of Bernardi (1947), 80 patients underwent occlusion of the testicular vein by detachable balloons, 47 patients were treated with percutaneous sclerotherapy, and 89 patients underwent laparoscopic varicocele treatment. The laparoscopic occlusion of the testicular vessels was done in two different ways: (1) coagulation of the testicular veins with electrocoagulating tweezers, and (2) occlusion of the suprainguinal testicular vessel with metal clips and transection of the vessels. Laparoscopic Group 1 showed a clearly higher complication rate and recurrence rate in comparison with the other methods, whereas in Group 2 we observed the best results with only 4% complications and recurrences. Because of its higher complication rate and recurrence rate, laparoscopic electrocoagulation of the testicular veins proved to be inadequate.

Adolescent↗

PubMed1994

[An analysis of the surgical treatment of tumors of the upper urinary tract].

Over a ten-year period (1982-1993), forty-three patients with tumors of the upper urinary tract are operated in the urological clinic of the Medical University--Pleven. The types of operative interventions used include: radical nephroureterectomy with resection of the urinary bladder in 23 patients, with a postoperative incidence of recurrences amounting to 21.7 per cent; nephroureterectomy (7 cases) with 42.85 per cent recurrences; nephroureterectomy plus postoperative endoscopic electrocoagulation of the ureteral residue (9 cases) with 11.85 per cent recurrences; resection of the distal portion of the ureter plus ureterocystoneoanastomosis (4 cases) with 25 per cent recurrences. Analysis of the incidence rate of recurrences after various types of operations shows that nonradical procedures carry greater risk. Patients where for various reasons radical operation is impracticable, postoperative endoscopic electrocoagulation of the ureteral residue and bladder mucosa surrounding its orifice, substantially decrease the incidence rate of recurrences.

Adenocarcinoma↗

PubMed1997

Colonic angiodysplasia.

Colonic angiodysplasia (AD) is an important vascular lesion responsible for approximately 6.0% of cases of lower gastrointestinal hemorrhage. Lesions are usually located in the right colon and, although the pathophysiology is unknown, most are probably acquired as the result of a degenerative process associated with aging. Diagnosis is usually made during colonoscopy, but angiography can be efficacious when hemorrhage is severe. Most patients with bleeding AD are treated by endoscopy. Various methods have been used (monopolar electrocoagulation, injection therapy, contact probes, and lasers) with acceptable safety and success. perforation of the right colon is the main concern, especially with monopolar electrocoagulation and the YAG laser. In clinical practice, contact probes are used most often, although this approach has not been well studied as treatment for colonic AD.

Angiodysplasia↗

PubMed1996

Endovascular embolization of intracranial aneurysms with self-made tungsten coils in a dog model.

OBJECTIVE: To evaluate the embolization effects and the long-term histologic changes, including the ultrastructure of the neoendothelium, in experimental canine aneurysms obliterated with self-made tungsten microcoil. METHODS: Twenty-eight experimental aneurysms were microsurgically created in 14 mongrel dogs by using end-to-side jungular carotid anastomosis. The aneurysms were obliterated with either self-made tungsten microcoil alone or the microcoil plus micro direct current electrocoagulation, with preservation of the parent vessel. The animals were kept in observation. 48 hours, 4 weeks, and 4 months after the embolization of the aneurysms, repeated carotid arteriography was performed to assess the potential recanalization of the aneurysms. The animals were then respectively killed and submitted for autopsy. The carotid artery and the embolized aneurysms were resected and studied with light and electron microscopy. RESULTS: A total of 14 obliterated aneurysms were completely excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the microcoils with very minimal inflammatory reaction. CONCLUSIONS: Tungsten microcoils are a relatively ideal embolic material at present for endovascular treatment of aneurysms. Microcoils plus micro direct current electrocoagulation yield more reliable, accurate, and safer embolic effects than microcoils alone for the obliteration of aneurysms.

Animals↗

PubMed1987

Trigeminal neuralgia and multiple sclerosis.

In a series of patients with trigeminal neuralgia (TN) who were treated with radiofrequency electrocoagulation of the gasserian ganglion and retrogasserian rootlets, either alone or with glycerol, 16 patients with TN and multiple sclerosis (TNMS) are compared with 219 patients with TN without MS. Patients with TNMS were younger and more likely to have bilateral facial pain than those with TN alone. Probability of ipsilateral recurrence was calculated on the basis of Kaplan and Meier product-limit estimates and showed no significant differences in the two groups.

Adult↗

PubMed1989

A significant new contribution to radical head and neck surgery. The argon beam coagulator as an effective means of limiting blood loss.

A new argon beam coagulator system promises a radically different form of electrocoagulation. Rarely does a tool make such an important contribution to the surgical armamentarium. This instrument reduces blood loss by up to half via rapid superficial coagulation, even when severe bleeding occurs. It causes minimal tissue damage, coagulates large vessels (2 to 3 mm in diameter), reduces the risk of postoperative hemorrhage, and markedly reduces operative time. Since the coagulation is superficial, healing appears to be unimpaired. We describe our experience with this new instrument (video tape recordings demonstrating its use in surgical procedures are available).

Argon↗

PubMed1993

Sphincter-saving alternatives in the management of adenocarcinoma involving the distal rectum. 5-year follow-up results in 40 patients.

We reviewed the treatment outcome in 40 patients undergoing full-thickness local excision (seven patients) or electrocoagulation (33 patients) for adenocarcinoma of the rectum. Patients were followed up for a minimum of 5 years or until death (mean follow-up, 7.6 years). Twenty-two patients (55%) survived 5 years free of disease or were free of disease at the time of death due to other causes following local treatment. Eight (62%) of 13 patients with persistent or locally recurrent disease were successfully treated with additional local therapy, rectal resection, or combined radiation therapy and chemotherapy. Overall, 30 (75%) of 40 patients embarking on a program of local treatment for carcinoma of the rectum survived 5 years free of disease or were free of disease at the time of death due to other causes.

Adenocarcinoma↗

PubMed1989

Palliative management of esophageal cancer.

Symptomatic esophageal cancer is usually an advanced disease and only palliation is possible in the majority of the cases. Endoscopic methods of palliation are becoming very popular because of the simplicity and the low incidence of morbidity and mortality. Endoscopic laser therapy, dilatation, placement of endoprosthesis, bipolar electrocoagulation, and injection therapy are the various methods currently in use. The advantages and disadvantages of different methods are discussed and the need for controlled trials highlighted.

Dilatation↗

PubMed1985

A comparison of bipolar and monopolar diathermy probes in experimental animals.

The effects of monopolar and bipolar diathermy were studied in laboratory animals. The power required to coagulate transected vessels in air was established and the effect of immersion in saline and water during electrocoagulation was investigated. Tissue heat conduction from each type of probe was measured and compared. Tissue damage was assessed by light microscopy of histochemically stained sections. The bipolar system operated at a lower power output (13 W) with less heat conduction, and was unaffected by the surrounding medium.

Animals↗

PubMed1988

Serum and tissue levels of platinum after cisplatinum instillation of the rat bladder.

The absorption of chemotherapeutics after local application in the urinary bladder is important for optimum therapy. We therefore investigated the absorption of Cisplatinum (Pt) through the bladder wall in 100 female Sprague-Dawley-rats after instillation under different clinical and pharmacological conditions. Only low platinum (Pt)-concentrations of about 1 microgram/ml could be detected in the serum using unmodified Cisplatinum solutions for instillation in the rat bladder indicating a rather low absorption rate for Cisplatinum. The extent of the absorption of Cisplatinum through the instilled bladder increased with the instilled volume. The absorption rate also increased after electrocoagulation and during cystitis with a maximum concentration of about 2.64 micrograms/ml. Correspondingly the vesicoplasmatic gradient factor clearly decreased. On addition of the detergent Tween 80, the serum Pt-concentration increased rapidly during the initial 30 min. Under these conditions Cisplatinum penetrated the bladder wall, about three times more effectively than in the absence of Tween while entering the systemic circulation only at about twice the normal rate without Tween 80. On addition of the polar organic solvent dimethylsulfoxide (DMSO) serum Pt-concentration increased continuously during the following 2 to 3 h reaching maximum values of about 13.3 micrograms/ml. The greatest accumulation of Pt in the bladder tissue (about 1,600 micrograms Pt/g tissue) was also observed under these conditions. A comparison of the Pt-concentration in serum with that in the bladder wall showed the most favourable relation of high tissue penetration and low serum concentration using Tween 80.

Animals↗

PubMed1983

A reproducible model for chronic renal failure in the mouse.

Chronic renal failure was induced in mice using bilateral electrocoagulation of the renal cortex. Thermal injury via an angled point cautery was applied to the fully exteriorized right kidney. Following a 10-day interval the left kidney was injured in a similar fashion. The incidence of local complications was negligible and because of the limited blood loss, very small laboratory animals can be used. By restricting trauma to varying proportions of the visible cortex graded levels of injury were obtained. Thus this model can produce a uniform pattern of renal failure and will therefore facilitate the acquisition of information on the biological consequences of chronic uraemia.

Animals↗

PubMed1983

Permeability of the rat bladder to Cisplatinum under different conditions: comparison with Mitomycin C and Adriamycin.

In 50 female Sprague-Dawley rats the absorption of Cisplatinum through the bladder wall was studied. Under different conditions, including cystitis and electrocoagulation of the bladder mucosa, the absorption was low and the measureable serum concentrations did not exceed 2.64 micrograms/ml. The influence of Tween 80--a non-ionic surfactant--on the absorption is investigated. The results are compared with those found for Adriamycin and Mitomycin C under identical conditions.

Animals↗