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At least 1,063 records · Page 59Linked to original sources
PubMed1998

[Intuitive dialogue--a way out of emotional blockages with defocusing imagination].

Intuitive dialogues allows to loose trauma-, conflict-, and subject-fixations. The defocusing imagery plays an important part role in this method. The metaphorical method is oriented on Winnicott, M. Balint, and on Ernesto Grassi and on the theory and praxis of modern art-therapy. A specific Balint group in the dying scene is described, in which role- and relationship conflicts are defocused in form of a mood oriented sensory-metaphorical process. Finally the theory and method of the intuitive dialogue is discussed, especially in the therapy with tortured patients.

Art Therapy↗
PubMed1986

Spatial and temporal relationships between cell death and tissue overgrowth in imaginal wing disks of the Drosophila mutant l(3)c43hs1.

The temperature-sensitive mutant l(3)c43hs1 is lethal at the restrictive temperature late in the last larval instar and has wing disks that show excessive growth when larvae are reared at 25 degrees C. Such mutant disks give rise to defective wings showing duplications and deficiencies. Abnormal folding patterns are localized to the region between the wing pouch and the area where adepithelial cells are found; the disks retain an epithelial morphology. Apoptotic cell death is distributed throughout the wing disks without any obvious concentration of dead cells in a specific area. Cell death is seen as early as 12 hr after a shift to the restrictive temperature. Temperature shift experiments also show that cell death precedes the onset of overgrowth, but since the spatial distribution of death is not localized to the regions of abnormal folds, it is unlikely that cell death and overgrowth are causally related.

Animals↗
PubMed1975

Pattern formation in the imaginal wing disc of Drosophila melanogaster: fate map, regeneration and duplication.

Fragments of the wing disc of Drosophila (fig. 2) were either injected into mature third instar larvae for immediate metamorphosis, or cultured in adult abdomens for seven days before being transferred to larvae for metamorphosis. The structures differentiated during metamorphosis were then analysed. The results of the first series of experiments were used to construct an accurate fate map of the disc, and those of the second series were used to determine the regenerative properties of the disc. The fate map (fig. 7) shows presumptive proximal parts (notum, pleura, and dorsal and ventral hinge) at the two ends of the disc, with presumptive distal wing parts in between. During metamorphosis the disc epithelium folds upon itself along the presumptive wing border, bringing dorsal and ventral wing and hinge surfaces into apposition. The wing surfaces occupy a much smaller relative area, and the hinge parts a much larger relative area, in the fate map than in the adult structure. The cultured fragments, in general, behaved in accordance with the rule that when two cut surfaces are created by cutting across the disc, regeneration occurs from one of the cut surfaces and duplication occurs from the other (fig. 14). It was possible to define a level in the longitudinal axis of the disc from which regeneration proceeds outwards. Cut surfaces facing away from this level show regeneration, while cut surfaces facing this level undergo duplication. Similar behavior was found for the transverse axis, and for two diagonal series of cuts. Some fragments with two cut edges could regenerate from one edge while duplicating from the other, whereas others could regenerate from two cut edges simultaneously. However, fragments with four cut edges showed incomplete regeneration, and a high tendency to duplicate even though regeneration in all directions might have been expected on the basis of the other experiments.

Animals↗
PubMed1987

Protein synthesis during imaginal disc pattern regulation.

We have examined the pattern of protein synthesis during wing disc pattern regulation. Although in vivo culture dramatically alters the pattern of abundant protein synthesis in wing discs, only one protein--RG38--changes specifically in response to pattern regulation. This polypeptide, previously identified as being nonuniformly distributed in wing and haltere discs, is synthesized in a graded distribution across the wing disc. During wing disc pattern regulation, it acts as a molecular marker for regeneration of particular wing disc regions. Thus, the rate of RG38 synthesis increases during regeneration (by fragments with initial low levels) with kinetics that parallel those for regeneration as scored by the presence of adult cuticular structures.

Animals↗
PubMed2003

Postembryonic development of the wing imaginal discs in the female wingless bagworm moth Eumeta variegata (Lepidoptera, Psychidae).

The process of wing disc development and degeneration in the bagworm moth Eumeta variegata was investigated histologically. Morphological differences between two sexes first appear in the penultimate (eighth) larval instar. In the male, wing discs proliferate rapidly in the penultimate larval instar and continue proliferating; a conspicuous peripodial epithelium forms in the last (ninth) larval instar. The hemopoietic organs break down in this stage and disappear completely by the prepupal stage. In the female, in contrast, the wing discs remain as in the previous (seventh) instar, without proliferation of cells inside. No peripodial epithelium forms in the penultimate instar or later. Hemopoietic organs are still attached to the wing discs in the last larval instar and the entire wing discs transform into a plain, thick epidermis in the prepupal period. It is suggested that the hemopoietic organs may prevent the wing discs from developing in E. variegata.

Animals↗
PubMed1999

Comprehension regularity in Broca's aphasia? There's more of it than you ever imagined.

We analyze the comprehension data in Broca's aphasia, pooled together by Berndt, Mitchum, and Haendinges (1996). We show that once analyzed properly, these data have statistical structure that is very similar to that revealed by the analysis in Grodzinsky, Pinango, Zurif, and Drai (1999). The suggestion that the latter authors doctored the data to obtain a desired outcome is as false as the claim that the data in Berndt et al. show no regularity. Comprehension scores in Broca's aphasia do have statistical structure, which correlates with syntactic structure. Thus, the role of Broca's area and its vicinity in language processing can be made more precise.

Aphasia, Broca↗
PubMed2000

Larval multidendrite neurons survive metamorphosis and participate in the formation of imaginal sensory axonal pathways in the notum of Drosophila.

In each hemimesothorax of Drosophila, a cluster of five larval multidendrite neurons that survives metamorphosis is described. The cell bodies of these neurons, initially grouped together, spread out over the medial heminotum during early pupal stages and extend new dendrites. Growing axons from sensory bristle neurons first appear in a defined orientation specific for each macrochaete. They subsequently contact processes from the larval multidendrite neurons and then appear to follow the preestablished axon trajectories of the latter. Ablation of the multidendrite neurons during the larval stage causes bristle axons to adopt abnormal trajectories. We suggest that the persistent larval neurons participate in guiding axons of the bristles on the medial half of the notum to the posterior dorsal mesothoracic nerve leading to the central nervous system.

Animals↗
PubMed2001

Perturbing nuclear transport in Drosophila eye imaginal discs causes specific cell adhesion and axon guidance defects.

To study nucleocytoplasmic transport during multicellular development, we developed a sensitive nuclear protein import assay in living blastoderm embryos. We show that dominant negative truncations of the human nuclear transport receptor karyopherinbeta/Importinbeta (DNImpbeta) disrupt mRNA export and protein import in Drosophila. To test the sensitivity of different developmental processes to nuclear trafficking perturbations, we expressed DNImpbeta behind the morphogenetic furrow of the eye disc, at a time when photoreceptors are patterned and project their axons to the brain. DNImpbeta expression does not disrupt the correct specification of different photoreceptors, but causes a defect in cell adhesion that leads to some photoreceptors descending below the layer of ommatidia. The photoreceptors initially project their axons correctly to the posterior, but later their axons are unable to enter the optic stalk en route to the brain and continue to project an extensive network of misguided axons. The axon guidance and cell adhesion defects are both due to a disruption in the function of Ketel, the Drosophila ortholog of Importinbeta. We conclude that cell adhesion and axon guidance in the eye have specific requirements for nucleocytoplasmic transport, despite involving processes that occur primarily at the cell surface.

Active Transport, Cell Nucleus↗