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PubMed1992

Antibodies to histones in systemic lupus erythematosus and drug-induced lupus syndromes.

Antihistone antibodies are some of the most frequent autoantibodies in rheumatic diseases and can represent useful diagnostic markers in some autoimmune syndromes. Histone epitopes are often located in accessible regions of chromatin or are conformational determinants resulting from the association of several components. These observations and studies with murine models of lupus strongly support the view that histones play a direct stimulatory role in triggering autoantibody production.

Antibodies↗
PubMedDate not supplied

[Comparative study of the activity of immunoglobulin G and therapeutic preparations of normal human immunoglobulin in patients with systemic lupus erythematosus and rheumatoid arthritis and in healthy persons].

The authors consider that the development of immunopathological reactions in SLE, AIDS depends on the reduction in normal gamma-globulin level in the patient's serum. The sera with anti-DNA, anti-HIV antibodies show a decreased binding of corresponding antigens and decreased concentrations of gamma-globulin with normal features.

Adolescent↗
PubMed1990

[The role of the thrombocyte and erythrocyte components of hemostasis in the development of thrombohemorrhagic complications in patients with systemic lupus erythematosus].

The authors evaluated changes of plasma, thrombocytic and erythrocytic links of hemostasis in 15 patients with thrombotic and in 30 with hemorrhagic complications in lupoid nephritis. Marked changes of thrombocytes, erythrocytes were caused by autoimmune processes with signs of thrombohemorrhagic syndrome requiring therapeutic correction using heparin and deaggregants under careful coagulographic control.

Blood Platelets↗