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At least 1,063 records · Page 59Linked to original sources
PubMed1997

Computer analysis of human depth EEG in different sleep stages.

This study compares delta (< 4 Hz), theta (4-8 Hz), alpha (8-12 Hz) and beta (12-20 Hz) band EEG signals during wakefulness, rapid-eye-movement (REM) sleep, and stage 1 and stage 2 non-REM sleep recorded from both surface and depth electrodes in patients with drug-resistant partial seizures. Computer analysis utilizing Fast Fourier Transforms (FFT) was performed with the Neurovision software developed for this purpose. Mean amplitudes were calculated for each of the frequency bands. Preliminary analysis was performed with emphasis on the presence and characteristics of theta activity in the hippocampus of the brain. Results demonstrate theta wave activity in the hippocampus with an increase of theta activity in REM sleep as compared to non-REM sleep (stages 1 and 2).

Adult↗
PubMed1976

Computer support of pharmaceutical services for ambulatory patients.

A prototype computerized pharmaceutical services support system (CPSSS) is described. CPSSS maintains records on approximately 40,000 patients; 1,300 outpatient prescriptions are dispensed per day. Using Univac hardware and software developed inhouse, CPSSS provides an online drug therapy profile. The prescription label, including auxiliary information, storage and stability guidelines as well as the traditional information, is automatically generated. Prior to medication dispensing, all information is verified by a pharmacist after the computer searches the patient medication profile for 5,400 potential drug-drug, 1,500 drug-disease state, over 100 drug-allergy and 200 drug-laboratory test interactions as well as identifying duplicate pharmacological therapy. Retrospectively, the patient population is described as to sex, age and number of diagnoses. The number of prescriptions per physician also is reported. Twenty drugs represent one-half of the total prescriptions, with 32% of patients taking diuretics and 30% taking tranquilizers. All new prescriptions were prospectively reviewed. Approximately 2% had potential interactions or pharmacological duplication of therapy problems. Approximately 30% of all new prescriptions duplicated exactly an active prescription on file. When a pharmacist initiated physician contact as a result of CPSSS and profile review, physicians changed therapy approximately 73% of the time when informed of duplicate therapy, 27% of the time when informed of potential drug-disease state interactions and 32% of the time when informed of potential drug-drug interactions.

Ambulatory Care↗
PubMed2005

Development of a software tool for in silico simulation of Escherichia coli using a visual programming environment.

This study describes the development of a software tool, EcoSim, to assist users in implementing quantitative in silico simulation easily. It consists of four parts: extracellular environment and constraints setting mode, table for optimal metabolic flux distribution and chart for changes of substrate concentration, dynamic flux distribution viewer and dynamic hierarchical regulatory network viewer. Representation of a hierarchical regulatory network was constructed with defined modeling symbols and weight in the central Escherichia coli metabolism. All programming procedures for EcoSim were accomplished in a visual programming environment (LabVIEW). To illustrate quantitative in silico simulation with EcoSim, this program was performed on E. coli using glucose and acetate as carbon sources. The simulation results were in agreement with the experimental data obtained from the literature. EcoSim can be used to assist biologists and engineers in predicting and interpreting dynamic behaviors of E. coli under a variety of environmental conditions.

Acetates↗
PubMed2006

[Development of new software (Ver. 2.0) based on the Bayesian estimation utilized in the therapeutic drug monitoring of teicoplanin, a glycopeptide antibiotic].

We developed a new software (Ver. 2.0) based on the Bayesian estimation utilized in the therapeutic drug monitoring (TDM) of teicoplanin, a glycopeptide antibiotic, for the estimation of individual pharmacokinetic parameters. Individual pharmacokinetic parameters were calculated by a least squares methods, MULTI2 (BAYES), and a two-compartment model with population pharmacokinetic parameters in adult patients in Japan was adopted. The predicted teicoplanin concentrations in patients were similar to the observed concentrations, suggesting that the software predicts with acceptable precision. This new software is now available in clinical practice.

Adult↗
PubMed2005

The CCPN data model for NMR spectroscopy: development of a software pipeline.

To address data management and data exchange problems in the nuclear magnetic resonance (NMR) community, the Collaborative Computing Project for the NMR community (CCPN) created a "Data Model" that describes all the different types of information needed in an NMR structural study, from molecular structure and NMR parameters to coordinates. This paper describes the development of a set of software applications that use the Data Model and its associated libraries, thus validating the approach. These applications are freely available and provide a pipeline for high-throughput analysis of NMR data. Three programs work directly with the Data Model: CcpNmr Analysis, an entirely new analysis and interactive display program, the CcpNmr FormatConverter, which allows transfer of data from programs commonly used in NMR to and from the Data Model, and the CLOUDS software for automated structure calculation and assignment (Carnegie Mellon University), which was rewritten to interact directly with the Data Model. The ARIA 2.0 software for structure calculation (Institut Pasteur) and the QUEEN program for validation of restraints (University of Nijmegen) were extended to provide conversion of their data to the Data Model. During these developments the Data Model has been thoroughly tested and used, demonstrating that applications can successfully exchange data via the Data Model. The software architecture developed by CCPN is now ready for new developments, such as integration with additional software applications and extensions of the Data Model into other areas of research.

Computer Graphics↗
PubMed2000

The development of a software program for analyzing spontaneous and externally elicited skin conductance changes in infants and adults.

OBJECTIVES: Changes in palmar and plantar skin conductance (SC) are due to outgoing bursts in the postganglionic efferent sympathetic cholinergic fibres, which responds to changes in central arousal state. The purpose of this study was designed to develop a software program for analyzing spontaneous and external elicited SC changes for infants and adults. METHODS: The program was designed to calculate the number and mean amplitude of the waves as well as the mean basal level in a given period. Different pre-set values for the minimum amplitude, maximum slope and minimum width of the spontaneous waves were used in the analysis program, and the results were compared with manually counted waves. The program was also used to perform coherent averaging of repeated elicited SC changes. For the mean elicited skin conductance responses, the latency time, response amplitude and recovery time were calculated. The habituation pattern could be calculated semi-automatically by analyzing each response. RESULTS: For SC waves, the minimum amplitude and the maximum slope should be, respectively, 0.02 microsiemens (microS) and 2 microS/s for infants and adults, and the width of the waves should be at least 1 s for adults, and unlimited for infants. The coherent average method was found to be a satisfactory method for revealing whether a subject responded to stimuli, and is recommended, especially for infants. CONCLUSIONS: Spontaneous and stimulated skin conductance are easily analyzed by this software program.

Adult↗
PubMed1994

Data management in a two-dimensional gel electrophoresis laboratory: "gelscript 1" software.

We have developed a software package "gelscript 1", to perform data operations in a laboratory that runs and analyzes a large number of two-dimensional (2-D) gels. This system is managed automatically by the "4th Dimension" relational database on a Macintosh platform. A guiding principle in the development of "gelscript 1" was that any piece of information is entered into the system only once, and is retrieved, copied, inserted or checked whenever required. In addition to saving labor, this principle ensures consistency and integrity of the database. The system always "knows" how many gels were run from any one sample, how long the films were exposed or were supposed to be exposed. It keeps track of data throughout all operations, warns of improper sample assignments, and prints labels for films, samples, protocols, etc. The software can be adapted to other applications, in which many samples are processed and where cross-referencing is needed.

Databases, Factual↗
PubMed1995

A graphics-based software system to develop and analyze models of musculoskeletal structures.

We have created a graphics-based software system that enables users to develop and analyze musculoskeletal models without programming. To define a model using this system one specifies the surfaces of the bones, the kinematics of the joints and the lines of action and force-generating parameters of the muscles. Once a model is defined, the function of each muscle can be analyzed by computing its length, moment arms, force and joint moments. The software has been implemented on a computer graphics workstation so that users can view the model from any perspective and graphically manipulate the joint kinematics and musculoskeletal geometry. Models can also be animated to visualize the results of motion analysis experiments. Since the software can be used to study models of many different musculoskeletal structures, it can enhance the productivity of investigators working on diverse problems in biomechanics.

Algorithms↗
PubMed2001

The development of a software program for analyzing skin conductance changes in preterm infants.

OBJECTIVES: Changes in palmar and plantar skin conductance (SC) are due to outgoing bursts in the postganglionic efferent sympathetic cholinergic fibres, which respond to changes in the central arousal state. An apparatus that measures SC by applying an alternating voltage is sensitive enough to measure SC changes in preterm infants. The purpose of this study was to develop a software program for analyzing SC in premature infants. METHODS: The software program was designed to calculate the number and mean amplitude of the waves and the mean SC changes during a given period. Different pre-set values for minimum amplitude, maximum slope and minimum width of the waves were used in the program and the results were compared with manually counted waves. RESULTS: For SC waves, the optimal minimum amplitude was found to be 0.015 microS, the maximum slope of the waves could, with the same result, be 1, 2 or 5 microS/s and the optimal width of the waves was found to be unlimited. CONCLUSIONS: SC in preterm infants is easily analyzed by this software program.

Female↗
PubMed1989

[The mapping information system: an experience in the development of appropriated software for analysis and presentation of information].

The mapping system (SIMAP), is an experience of the Institute of Nutrition of Central America and Panama in developing an appropriate software (programs) for information needs of the countries of the Central American Isthmus. Through its main characteristics: geographic association, easy use, flexible and versatile, SIMAP is a tool that can easily be used for decision-making in the different sectors. The system's main modules are presented in this article as well as some applications where the SIMAP would serve as support in the analysis and interpretation of information.

Adolescent↗
PubMedDate not supplied

Development of a computer software for easy storage and analysis of fibreoptic bronchoscopy data.

OBJECTIVE: To develop a simple software for management of fibreoptic bronchoscopy records. METHODS: After identification of the specific needs at our hospital, a software was developed. A graphical interface with structured data entry related to patient information and diagnosis, bronchoscopic findings and specimens obtained, and their reports were envisaged. After initial construction, the software was tested over a four-week period. The software was put to routine use after necessary corrections, and validated over the next few months through actual data entry. RESULTS: The software has various modules for input and modification of data, as well as for generation of reports, and can work both on stand-alone personal computers and on networks. With little practice, residents soon became adept at entering details correctly and quickly. The slightly increased time of data entry into the computer was more than made up by uniform and complete report generation. The database component was evaluated by analyzing 1000 consecutive records entered over a 14-month period, and no discrepancies were observed. CONCLUSION: A user-friendly software providing uniform and complete data entry regarding fibreoptic bronchoscopic procedures was developed.

Bronchoscopy↗
PubMed2000

Costs of smoking during pregnancy: development of the maternal and child health smoking attributable mortality, morbidity and economic costs (MCHSAMMEC) software.

The development and availability is described of new, user friendly software, the Maternal and Child Health Smoking Attributable Mortality, Morbidity and Economic Costs (MCHSAMMEC), that will allow states and other entities to estimate pregnancy related, smoking attributable costs for their population. The methodology underlying the MCHSAMMEC software, including calculations used in the prevalence based analysis of smoking attributable mortality and costs of infant neonatal care, are described, along with design and data management features and possible applications of the software for policy and program development at various levels of the health care system.

Adult↗
PubMed2006

Development of a software tool for computation of parenteral nutrition in adults, and its potential role in improving nutritional care.

The detailed development of a computer program for management of parenteral nutrition (PN) in adults is described. Strengths and weaknesses are mentioned. By using the software, individualized PN prescriptions based on patient age, weight, sex, and clinical condition can be determined and available formulations can be automatically selected from incorporated databases. Automated PN management potentially enhances our ability to provide nutritional support with greater accuracy and precision and reduces the time required for writing and calculations. Day-to-day changes may also be monitored rapidly, simply, and safely.

Adult↗
PubMed1999

Techniques for development of safety-related software for surgical robots.

Regulatory bodies require evidence that software controlling potentially hazardous devices is developed to good manufacturing practices. Effective techniques used in other industries assume long timescales and high staffing levels and can be unsuitable for use without adaptation in developing electronic healthcare devices. This paper discusses a set of techniques used in practice to develop software for a particular innovative medical product, an endoscopic camera manipulator. These techniques include identification of potential hazards and tracing their mitigating factors through the project lifecycle.

Marketing of Health Services↗
PubMed1986

Use of the interactive videodisc to teach pathology: a preliminary report.

Although use of computers in education dates to the early 1960s,1-3 it is only with the arrival of the "microcomputer revolution" that computers have become economically feasible in medical education. The advent of inexpensive and relatively powerful microcomputers initiated something of a chain reaction; microcomputers became available for educational purposes, thus creating a market for educational software. This accelerated development of educational software in turn made microcomputers more useable. While synergistic hardware and software development has occurred repeatedly in the microcomputer industry, it is only in the beginning stages in medical education. This paper presents a discussion of the development of one computer-assisted instructional program that utilizes an interactive videodisc format.

Computer-Assisted Instruction↗