PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “brain function”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,063 records · Page 59Linked to original sources
PubMedDate not supplied

Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids.

The concentration of the major polyunsaturated fatty acid (PUFA) in brain, docosahexaenoate, may be markedly reduced by two or more generations of dietary restriction of sources of n-3 fatty acids in the diet. Such a deficiency was induced through the feeding of safflower oil as the principal source of essential fatty acids. The reference point for this diet was an n-3 adequate diet to which alpha-linoleate and docosahexaenoate were added through the addition of a small quantity of flax seed or algael oils, respectively. The loss of brain DHA was associated with poorer performance in spatial tasks and an olfactory-cued reversal learning task. No difference could be observed in the hippocampal gross morphology. This study demonstrates the importance of providing a source of n-3 fatty acids during mammalian growth and development.

Animals↗
PubMed1990

New 18F tracers for the investigation of brain functions.

Advances in the synthetic methodology of radiofluorination have increased the number of clinically useful 18F labeled tracers for positron emission tomography of the brain. It is now possible to measure in vivo with 18F tracers regional cerebral blood flow (18F-fluoromethane), dopamine metabolism (6-18F-fluoro-L-dopa) and dopamine D-2 receptor density (N-18F-fluoroethylspiperone). At present 18F tracers are being developed that will, in the near future, make accessible to investigation cerebral serotonin metabolism, serotonin receptor density, melatonin receptor density, activity of L-aromatic acid decarboxylase, and protein synthesis rate.

Brain↗
PubMed1981

The use of brain electrical potentials (BEP) to study localization of human brain function.

Various techniques such as neuropsychological diagnosis of individuals with focal lesions, stimulation of neurosurgery patients, and regional cerebral blood flow have been used to elucidate the major anatomical and functional divisions of the human cerebral cortex. Because of insufficient spatial sampling and other limitations, only minor support for these divisions comes from brain electrical potential (BEP) experimentation. The use of EEG to localize different neuropathologies and to screen and track the evolution of seizure disorders is fairly reliable and still widely practiced. Its use, however, in localizing higher cognitive functions is much more complicated and has not stood the test of scientific scrutiny because of methodological problems. More specifically, the failure to control for the stimulus, response and performance related properties of tasks in experiments has rendered ambiguous the results of most EEG studies of higher cognitive functions. Those studies which actually controlled for these properties did not find and differences between tasks.

Brain↗