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PubMed2006

A systematic review of multivitamin and multimineral supplementation for infection.

BACKGROUND: Infections are major causes of morbidity and mortality worldwide. Micronutrients have important functions in the body's immune system. This systematic review examined the evidence from randomized controlled trials (RCTs) on whether multivitamin and multimineral supplementation is effective in reducing infection. METHODS: Electronic databases searched: Cochrane Controlled Trials Register, EMBASE, MEDLINE, BIOSIS, CAB abstracts. Hand searching of nutrition journals and reference lists was carried out. RCTs and quasi-randomized trials of supplementation of adults with at least two vitamins or minerals or a combination were selected. Study results were combined in meta-analysis plots where appropriate. RESULTS: Twenty studies were included in the review. Small numbers were available for each meta-analysis. Results are presented here without the Chandra group studies. No significant difference was found in the number of episodes of infection in older people (>or = 65 years) between those supplemented and those not supplemented; (WMD) 0.06 [95% confidence interval (CI) -0.04, 0.16], P = 0.25. In other adults groups, there were significantly less episodes of infection in those supplemented; (WMD) -1.20 (95% CI -2.08, -0.32), P = 0.008. There was no significant difference between those older people supplemented and those not supplemented in the number with at least one infection; relative risk (RR) 0.98 (95% CI 0.86, 1.11), P = 0.77. Similarly, there was no significant difference in the numbers in other adult groups who had at least one episode of infection between those supplemented and those taking placebo; (RR) 0.81 (95% CI 0.65, 1.00), P = 0.06. Subgroup analyses suggested that supplemented people aged 65 years or over may benefit more if they are undernourished and supplemented for over 6 months, WMD -0.67 infections (95% CI -1.24, -0.10), P = 0.02. CONCLUSION: Further large trials are needed, particularly in undernourished older people. Trials of supplementation periods of over 6 months are recommended.

Adult↗

PubMed2006

Evidence for impaired mnemonic strategy use among patients with schizophrenia using the part-list cuing paradigm.

PURPOSE: Strategic and mnemonic abilities of person with schizophrenia (SCZ) were studied using a part-list cuing (PLC) task. In this task, presentation of retrieval cues in the form of a subset of studied words typically impairs recall of the remaining items. This impairment is thought to reflect a disruption of participants' natural retrieval strategies. METHODS: Participants with SCZ and healthy controls (ns = 28) studied word lists with three different levels of semantic organization: (a) unrelated, (b) categorized, but presented in a random order, and (c) presented by category. For each type of list, participants recalled words under both free-recall and PLC conditions. RESULTS: Consistent with SCZ-related impairment of strategic retrieval processes, the SCZ group was less disrupted by PLC interference than controls in the unrelated-list condition. Comparison of free recall across lists also indicated a consistent deficit in SCZ despite varying levels of difficulty and retrieval contexts. Nonetheless, the SCZ group demonstrated parallel improvement to the healthy group with increasing list organization. CONCLUSIONS: These results provide evidence of deficient retrieval processes in SCZ in a context placing maximal requirements for utilization of self-initiated, effortful, mnemonic strategies. Unlike most extant results demonstrating mnemonic impairment in persons with SCZ, the present results cannot be accounted for by task difficulty; SCZ participants' recall was less disrupted by PLC than was that of healthy participants. Results also demonstrated that SCZ participants could benefit, in terms of recall and strategy use, from list organization when this structure was explicitly provided at test.

Adult↗

PubMed2000

Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis.

PURPOSE: Recent randomized trials in women with node-positive breast cancer who received systemic treatment report that locoregional radiation therapy improves survival. Previous trials failed to detect a difference in survival that results from its use. A systematic review of randomized trials that examine the effectiveness of locoregional radiation therapy in patients treated by definitive surgery and adjuvant systemic therapy was conducted. METHODS: Randomized trials published between 1967 and 1999 were identified through MEDLINE database, CancerLit database, and reference lists of relevant articles. Relevant data was abstracted. The results of randomized trials were pooled using meta-analyses to estimate the effect of treatment on any recurrence, locoregional recurrence, and mortality. RESULTS: Eighteen trials that involved a total of 6,367 patients were identified. Most trials included both pre- and postmenopausal women with node-positive breast cancer treated with modified radical mastectomy. The type of systemic therapy received, sites irradiated, techniques used, and doses of radiation delivered varied between trials. Data on toxicity were infrequently reported. Radiation was shown to reduce the risk of any recurrence (odds ratio, 0.69; 95% confidence interval [CI], 0.58 to 0.83), local recurrence (odds ratio, 0.25; 95% CI, 0.19 to 0.34), and mortality (odds ratio, 0.83; 95% CI, 0.74 to 0.94). CONCLUSION: Locoregional radiation after surgery in patients treated with systemic therapy reduced mortality. Several questions remain on how these results should be translated into current-day clinical practice.

Breast Neoplasms↗

PubMed2003

5-year outcome of a prospective randomized trial to compare transurethral electrovaporization of the prostate and standard transurethral resection.

OBJECTIVES: To update our prospective randomized trial comparing the safety, efficacy, and durability of transurethral electrovaporization of the prostate (TUVP) using the VaporTrode with standard transurethral resection of the prostate (TURP). METHODS: A total of 104 patients, taken from the waiting list for surgery for benign prostatic hyperplasia were randomized to TUVP (52 patients, mean age 67.5 years) or TURP (52 patients, mean age 70.2 years). In each group, 51, 47, and 40 patients completed 1, 2, and 3 years of follow-up, respectively. Of the 104 patients, 27 TURP and 26 TUVP patients completed 5 years of follow-up. RESULTS: Both groups were comparable in terms of the mean preoperative International Prostate Symptom Score, quality-of-life score, maximal urinary flow rate, and postvoid residual volume. The follow-up data at 5 years showed a significant and maintained improvement in the mean International Prostate Symptom Score (TUVP: 5.9 +/- 6.3 versus TURP: 8.6 +/- 7.1, P = 0.16), quality-of-life score (TUVP: 1.1 +/- 1.2 versus TURP: 1.7 +/- 1.4, P = 0.09), and mean maximal urinary flow rate (TUVP: 21 +/- 9 mL/s versus TURP: 17.9 +/- 13.1 mL/s, P = 0.17), with decreases in the mean postvoid residual volume (TUVP: 27.3 +/- 44.3 mL versus TURP: 10.7 +/- 13.1 mL, P = 0.08). Two patients in each group (4%) developed urethral strictures. Two TURP patients (4%) developed bladder neck strictures compared with one TUVP patient (2%). In each arm, 7 patients (13%) underwent reoperation during a 5-year period (approximate reoperation rate: 3% in each arm per year). Postoperatively and during 3 years of follow-up, impotence was reported in 17% of the TUVP group and 11% of the TURP group (P = 0.49); retrograde ejaculation was reported in 72% of the TUVP group and 89% of the TURP group (P = 0.47). CONCLUSIONS: Our 5-year follow-up results confirm that TUVP is as effective as standard TURP in the treatment of moderate-size benign prostatic hyperplasia. The reoperation rate and long-term complication rate are comparable and the initial improvement has been maintained during a 5-year period for most patients in both groups.

Adenocarcinoma↗

PubMed2003

Design, optimization and evaluation of a Danish sentence test in noise.

The Danish sentence test DANTALE II was developed in analogy to the Swedish sentence test by Hagerman and the German Oldenburg sentence test as a new Danish sentence test in noise to determine the speech reception threshold in noise (SRT, i.e. the signal-to-noise ratio (SNR) that yields 500% intelligibility). Each sentence is generated by a random combination of the alternatives of a base list. This base list consists of 10 sentences with the same syntactical structure (name, verb, numeral, adjective, object). The test sentences were recorded and segmented in such a way that the coarticulation effects were taken into account in order to achieve a high perceived sound quality of the resynthesized sentences: 100 sentences were recorded, each coarticulation between each word and the 10 possible following word alternatives were recorded, and the correct coarticulation was used to generate the test sentences. Word-specific speech recognition curves were measured for each recorded word to optimize the homogeneity of the speech material and the measurement accuracy. Level corrections of particular words and a careful selection of the test lists produced a noticeable reduction in the variation in the distribution of word-specific SRT (standard deviation 1.75 dB instead of 3.78 dB). Therefore, the slope of the total intelligibility function was expected to increase from 8.30%/dB (raw test material) to 13.2%/dB (after modification). These theoretical expectations were evaluated by independent measurements with normal-hearing subjects, and, for the most part, confirmed. The reference data for the DANTALE II are: SRT=-8.43 dB SNR; slope at SRT, s50 = 13.2%/dB. The training effect was 2.2 dB and could be reduced to less than 1 dB if two training lists of 20 sentences were performed prior to data collection.

Adult↗

PubMed2004

Cognitive behavior therapy vs exposure in vivo in the treatment of panic disorder with agoraphobia (corrected from agrophobia).

Seventy-three psychiatric outpatients with DSM-IV diagnosis of panic disorder with agoraphobia were assessed with a battery of independent assessor, self-observation, self-report and behavioral measures before and after therapy, and at a 1-yr follow-up. They were randomly assigned to Exposure in vivo (E; n = 25), Cognitive Behavior Therapy (CBT; n = 26), or a Wait-list control (WLC; n = 22) and received 12-16 individual therapy sessions, once weekly. The treatments yielded significant improvements, both on panic/agoraphobia measures and on measures of general anxiety, depression, social adjustment and quality of life, which were maintained at follow-up. However, there were no significant differences between E and CBT. The three criteria of clinically significant improvement were achieved by 67% of the E-patients and 79% of the CBT-patients at post-treatment, and 74% and 76%, respectively, at follow-up. The conclusion that can be drawn is that adding cognitive therapy to exposure did not yield significantly better results than for exposure alone.

Adaptation, Psychological↗

PubMed2004

An effective exercise-based intervention for improving mental health and quality of life measures: a randomized controlled trial.

OBJECTIVES: This study investigates the effectiveness of 24-week aerobic and weight-training exercise plus behavior modification for mental health and quality of life (QOL) outcomes. METHODS: Mental health and QOL data was collected using the Depression Anxiety and Stress Scales and SF-36 Health Status Survey, respectively. Employees from a single work-site were randomized into either treatment or wait-list control groups. RESULTS: Mental Health (P = 0.005), Vitality (P < 0.001), General Health (P = 0.009), Bodily Pain (P = 0.005), Physical Functioning (P = 0.004), Depression (P = 0.048), and Stress (P = 0.036) scales significantly improved for the treatment group compared to wait-list controls after 24 weeks. CONCLUSIONS: Multimodal exercise is as effective as other single-modality exercise treatments for depressive symptoms and, in contrast to other studies, does improve stress symptoms and QOL outcomes.

Adult↗

PubMed2000

Contemporary issues for spontaneous abortion. Does recurrent abortion exist?

Most of the time, spontaneous abortion is a random event and represents the natural selection process. Although a recurrent factor may be present and may cause one or more abortions for a given couple, such instances are rare. Well-substantiated causes include parental chromosomal abnormalities (e.g., translocation), antiphospholipid syndrome, PCOD, and maternal age greater than 40 years. Müllerian duplication defects are most likely a cause of pregnancy loss for some women. A growing body of evidence refutes the role of corpus luteum defect as a common cause of recurrent abortion. Other causes are numerically infrequent in occurrence. It is likely that cigarette smoking and alcohol consumption contribute to pregnancy wastage. Although some therapies for the causes listed herein have been proven effective by randomized controlled trials, most have not. Given the excellent outcome demonstrated for most couples with unexplained recurrent abortion in the absence of treatment, it is difficult to recommend unproven therapies, especially if they are invasive and expensive. Instead of examining the environment in which pregnancy has occurred or been planned, clinicians have simply counted the number of spontaneous abortions among couples in an attempt to determine who should be evaluated. The former approach would seem most appropriate and proactive.

Abortion, Habitual↗

PubMed1997

Cognitive-behavioral treatment of obsessive thoughts: a controlled study.

Twenty-nine patients with obsessive-compulsive disorder as diagnosed in accordance with the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised; American Psychiatric Association, 1987) who did not have overt compulsive rituals were randomly assigned to treatment and waiting-list conditions. Patients in the treatment condition received cognitive-behavioral therapy consisting of a detailed explanation of the occurrence and maintenance of obsessive thoughts, exposure to obsessive thoughts, response prevention of all neutralizing strategies, cognitive restructuring, and relapse prevention. Compared with waiting-list patients, treated patients improved significantly on measures of severity of obsessions, current functioning, self-report obsessive-compulsive symptoms, and anxiety. When waiting-list patients were subsequently treated, the combined group improved on all outcome measures. Treatment gains were maintained at 6-month follow-up. Results indicate that cognitive-behavioral therapy is effective in the treatment of patients with obsessive thoughts, a group that has often been considered resistant to treatment.

Adult↗

PubMed2002

Pooled cataract waiting lists: views of hospital consultants, general practitioners and patients.

In the National Health Service general practitioners (GPs) usually refer patients to named consultants; thus, waiting times for a particular procedure can vary greatly even within a single centre. An alternative is to pool the waiting list, with patients treated in turn by the consultant available. We sought opinions on this strategy, from patients, GPs, and consultants, in relation to cataract surgery. Questionnaires were sent to 776 consultant ophthalmologists; telephone interviews were conducted with 50 randomly selected Birmingham GPs; and 85 Birmingham patients listed for cataract surgery were asked whether they would change consultant to be operated on sooner. 503 (64%) of the consultants responded. Of consultants, 30% favoured pooled lists and 67% were against. Of patients, 82% favoured pooled lists and 18% were against. Of GPs, 92% favoured pooled lists and 8% were against. Some consultants thought that pooled lists were suitable for routine cases but not for more complex cases. 82% of patients expressed willingness to change consultant in order to get an earlier operation. In units with surgeons whose cataract-surgery practices are similar, pooled lists are one way to maximize theatre use and equalize waiting times for routine cases. The model could be applied to other routine surgical procedures such as hip replacement, herniorrhaphy and prostatectomy.

Aged↗

PubMed2005

Forced-choice analysis of segmental production by Chinese-accented English speakers.

This study describes the development of a minimal-pairs word list targeting phoneme contrasts that pose difficulty for Mandarin Chinese-speaking learners of English as a second language. The target phoneme inventory was compiled from analysis of phonetic transcriptions of about 800 mono- and polysyllabic English words with examples of all the vowels, diphthongs, and syllable onsets and codas of the language. The Mandarin-specific minimal-pairs list derived from the phonetic transcription analyses contains 190 items. Tape recordings were made of 8 Mandarin speakers reading a randomized version of target items from the minimal-pairs list and a set of 20 sentences. Listeners who were native American English speakers judged the words in a forced-choice task and wrote down what they understood of the sentences. Correlations between listener responses on the forced-choice task and the sentence intelligibility scores showed differences in the strength of the relationship with sentence intelligibility across categories of minimal-pairs contrasts. Multiple regression analysis found listener responses on the minimal-pairs task to account for approximately 76% of the variance in speakers' sentence intelligibility scores, showing that performance on the minimal pairs of the probe list does predict connected speech intelligibility. Analyses of individual contrasts indicate target phonemes most often misperceived by native listeners.

Adolescent↗

PubMed1997

The treatment of sexually dysfunctional men without partners: a controlled study of three behavioural group approaches.

BACKGROUND: Models of sex therapy for sexual dysfunction in single men are available, but their value is not well established. This controlled study compared three approaches to the treatment of sexually dysfunctional single men. METHOD: Sixty-nine single men diagnosed as sexually dysfunctional were randomly assigned to treatments focusing on either their sexual dysfunction, their interpersonal problems, a combination of both or a waiting list; 51 completed treatment and 50 the one-year follow-up. Treatment was administered in small groups in 15 weekly sessions and four six-weekly sessions during the first six months of a year-long follow-up. RESULTS: No clinically meaningful change was observed during the waiting period. In contrast, a significant and equivalent improvement was observed in all treatment groups by the end of treatment. However, differences between them were in evidence at 6 and 12 months' follow-up. CONCLUSIONS: Both treatments paying attention to the patients' interpersonal difficulties resulted in significantly better outcomes overall than the approach that concentrated on problems in sexual functioning alone.

Adult↗

PubMed2004

Selection of candidates with HCC for transplantation in the MELD era.

1. Liver transplantation is the main option for patients with early HCC who are not optimal candidates for surgical resection. 2. Shortage of donors is its main limitation, as waiting for a liver allows the tumor to progress and induce exclusion from the waiting list and death. 3. The absence of randomized controlled trials hinders the establishment of the most effective therapy to prevent tumor progression while waiting. 4. Live donation may be a cost-effective approach if optimal results are expected and the mortality risk for the donor is kept below .3%. 5. Priority policies have to be developed and refined to provide a fair and effective distribution of cadaveric organs.

Carcinoma, Hepatocellular↗

PubMed2002

Outcomes for untreated individuals involved in randomized trials of alcohol treatment.

Summarizing the relative effects of different treatments for alcohol use disorders is challenging because there is no standard treatment against which experimental treatments can be contrasted and comparisons to no-treatment control groups are rare. As alternative reference points, we examined outcomes and improvement for untreated participants (i.e., those in wait-list, no-treatment, and placebo conditions) in randomized trials of alcohol treatment over the last three decades. At followup, the average abstinence rate was 21% (n = 17 studies) and the mean level of alcohol consumption was 31 drinks per week (n = 29 studies). The reduction in drinking from baseline was.19 of a SD unit, or a 14% decrease from a baseline mean of 37 drinks per week (n = 17 studies). These values provide approximations of success and improvement that an active treatment for alcohol use disorders should surpass to be considered more beneficial than no treatment.

Alcohol Drinking↗

PubMed1990

A controlled study of effectiveness and patient suitability for short-term group psychotherapy.

A controlled, clinical trial investigation of short-term psychoanalytically oriented group psychotherapy (STG) was conducted which included eight psychotherapy groups led by experienced therapists. Patient psychological mindedness (PM) was investigated as a selection criterion and prognostic variable. Seventy-nine psychiatric outpatients experiencing prolonged or delayed grief reactions were matched for level of PM and then randomly assigned to STG or a wait list. There was repeated measurement of several areas and sources of outcome. Results indicated a strong main effect for STG but not for PM on outcome, and minimal evidence for an interaction effect. Benefits were maintained at six-month follow-up. Psychological mindedness emerged as highly predictive of attrition. A clinical discussion is presented wherein the efficacy of STG is considered as reflecting a good patient-treatment match.

Adaptation, Psychological↗

PubMed1989

Behavioral intervention to reduce AIDS risk activities.

Behavior change can curtail the spread of acquired immune deficiency syndrome (AIDS). In this study, 104 gay men with a history of frequent AIDS high-risk behavior completed self-report, self-monitoring, and behavioral measures related to AIDS risk. The sample was randomly divided into experimental and waiting-list control groups. The experimental intervention provided AIDS risk education, cognitive-behavioral self-management training, sexual assertion training, and attention to the development of steady and self-affirming social supports. Experimental group participants greatly reduced their frequency of high-risk sexual practices and increased behavioral skills for refusing sexual coercions, AIDS risk knowledge, and adoption of "safer sex" practices. Change was maintained at the 8-month follow-up.

Acquired Immunodeficiency Syndrome↗

PubMed2006

A randomized control trial of Internet-delivered HIV prevention targeting rural MSM.

The Internet may be important for delivering human immunodeficiency virus (HIV) risk reduction to men who have sex with men (MSM) in rural areas. This randomized control trial (RCT) tested the acceptability and efficacy of an Internet-delivered HIV risk-reduction intervention. Two modules include a conversation between an HIV-negative man and an HIV-positive man, with interactive graphics. Ninety men were randomly assigned to intervention or wait-list control and 79% completed the study. An 'intent-to-treat' model was used. HIV/acquired immune deficiency syndrome (AIDS) knowledge, self-efficacy and outcome expectancies increased after participating in the intervention, and changes were maintained at 1-week follow-up. Participants said they would participate again. This RCT provides support for the acceptability and efficacy of the Internet for delivering HIV prevention messages to rural MSM.

Adolescent↗

PubMed2004

Parent training for Attention Deficit/Hyperactivity Disorder: is it as effective when delivered as routine rather than as specialist care?

BACKGROUND: The effectiveness of parent training (PT) when delivered as part of specialist tier-two services for preschool AD/HD children has been recently demonstrated. AIMS: To assess the effectiveness of the same PT programme when delivered as part of routine primary care by non-specialist nurses. METHOD: A sample of 89 3-year-old children with preschool AD/HD took part in a controlled trial of an eight-week (one hour a week), health visitor delivered, PT package. Children, allocated randomly to PT (n = 59) and waiting list control (WLC; n = 30) groups, were compared. RESULTS: PT did not reduce AD/HD symptoms. Maternal well-being decreased in both PT and WLC groups. CONCLUSIONS: While PT is an effective intervention for preschool AD/HD when delivered in specialized settings, these benefits do not appear to generalize when programme are delivered as part of routine primary care by non-specialist nurses.

Adult↗