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Results for “11-Hydroxycorticosteroids”

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At least 109 records · Page 6Linked to original sources
PubMed1979

[Catecholamine sensitivity of the hypophyseal-adrenal system in the early ontogeny of rats].

The dynamics of the hypophyseal-suprarenal system reaction to catecholamines of different type of effect was studied in the Wistar rats during the first 16 days of life. The reaction to epinephrine was noted in 4 days old and to novodrin in 8 days old rats. Since the reaction to epinephrine acting on alpha- and beta-receptors appears ahead of that to novodrin acting selectively on beta-receptors, a suggestion was put forward to the effect that alpha-receptors matured more rapidly that beta-receptors. The increase of the system reaction to the stimulation of recepors sensitive to catecholamines was noted on the 12-14th days of life and appears to be related to the formation of central adrenergic mechanisms.

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PubMedDate not supplied

[Participation of different parts of the tonsils and the hippocampus in the regulation of the pituitary-adrenal cortex system in rats].

In experiments on rats the effect of electric coagulation of the tonsil and hippocamp on the functional activity of the pituitary-adrenal axis was studied. The weight of the adenohypophysis after the coagulation of the medial or lateral tonsils proved to decrease; the ACTH content in the hypophysis and the cortocosteroid level in the peripheral blood plasma diminished, and the compensatory hypertrophy of the remaining adrenal gland was intensified in rats with destroyed medial tonsil. The dorsal hippocamp coagulation was accompanied by a decrease in the adenohypophysis ACTH content, and the ventral hippocamp destruction led to reduction of corticosteroid secretion into the adrenal vein; in both cases the reaction to the irritation was potentiated. It was concluded that different parts of the tonsil and hippocamp influenced the pituitary-adrenal function unequally.

11-Hydroxycorticosteroids↗
PubMed1979

[Antistress effects of diazepam and activation of the positive reinforcing system upon changes on corticosteroid excretion and lipid level after peripheral electric pain stimulation].

It was shown in experiments on rats that the reaction of self-stimulation (SS) decreased the enhanced level of 11-hydrohycorticosteroids (11-HCS) in the blood after electrical pain stimulation(EPS) of the feet. Diazepam (1 mg/kg) decreased the levels of 11-HCS and beta-lipoproteids and increased the level of phospholipids after self-stimulation and pain stimulation. Diazepam and preliminary electrical pain stimulation induced activation of self-stimulation. It is concluded that diazepam and the activation of the positive reinforcing system exert similar effects on 11-HCS excretion and lipid levels after pain stimulation.

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PubMedDate not supplied

Adrenal reactivity to ACTH age changes in silver foxes inheriting different defensive behaviors.

We have studied the influence of selection for behavior in female silver foxes upon their adrenal reactivity to ACTH. It has been found that in the first year of life, in females from a population selected for domesticated behavior (tame), there is no differentiated adrenal response to different doses of ACTH. In wild females during the first year of life, varying strength of adrenal response to large and small doses of ACTH is noted. During the second year of life, the differential adrenal response to different doses of ACTH is improved in females of both behavioral groups; the reactivity of tame second-year females to small doses of corticotrophin surpasses that of wild second-year animals. It is concluded that during ontogeny in domesticated silver fox females there is a retardation in the establishment of an adequate response to ACTH by the adrenals, as compared to nondomesticated females.

11-Hydroxycorticosteroids↗
PubMed1979

[Dynamic behavior of the adaptive control system, hypothalamus--anterior pituitary--adrenal cortex. Animal experimental study of the adequate system dynamics of the direct and indirect parameters of the adaptive control system].

The dynamic response of the adaptive closed-loop control system hypothalamus-anterior pituitary-adrenal cortex after application of short-time disturb pulses were examined experimentally in the pig. Blood sampling was performed biologically non-reactive by chronically implanted vascular catheters in the upper vena cava. A circadian biphase periodical dynamics characterizes the distrubance response of the adaptive control system, respectively, its direct and indirect parameters. After distrubance variables induced initial excess the plasma corticosteriods undershoot the basic level over a long period. Conversely, the dynamics of the eosinophils is determined through an initial eosinopenic phase and a subsequent typical overshoot. Periodical dynamic is absent in the steady state. The controller of the adaptive system does not show any spontaneous activity in the steady state without stress. The absence of an endogenic periodicity of the dependent parameters likewise gives evidence of an active oscillator. On the other hand, the controlling unit of the adaptive system constitutes a control response of circadian periodicty after activation by disturbance variables in pulse shape. The high damping of the control system terminates the transient state within 24 hours, and the corticosteriods and the eosinophils reach the steady state level. This control quality of the adaptive control system gains a high importance in the origination of the spontaneous circadian periodicity by corticosteriods and eosinophils and for the biological compensation of exogenous distrubance variables.

11-Hydroxycorticosteroids↗
PubMed1975

Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency.

Seven urinary metabolites of tryptophan-kynurenine pathway were measured in riboflavin-deficient, pyridoxine-deficient, pair-fed and natural diet baboons. The most significant changes in the pyridoxine-deficient baboons was a mean sevenfold increase in the excretion of xanthurenic acid and a threefold decrease in 3-hydroxy anthranilic acid. The riboflavin-deficient baboons showed a twelvefold increase in the excretion of anthranilic acid, and a tenfold decrease in 3-hydroxy kynurenine. Red blood-cell pyridine nucleotides decreased only in the pyridoxine-deficient baboons, while plasma 11-hydroxy corticosteroids increased only in the riboflavin-deficient baboons. These results are discussed in relation to enzymatic changes that may be expected during these deficiencies.

11-Hydroxycorticosteroids↗
PubMed1979

[Structuro-metabolic mechanisms for integrating several endocrine organs].

Mechanisms of integration in the neuroendocrine system in the regimens of physiological rhythm (oestral cycle) and of isolated effect upon one link of the system (metapyrone administration) were studied with the aid of qualitative histoenzymological analysis of adenohypohysis and adrenal cortex, estimating the comoplex reorganization of various structural components of adenohypophysis and adrenal cortex in response to specific depression of glycocorticoid synthesis. The role of the so called unspecific reorganization in the maintenance of functional response to isolated effects upon certain endocrine functions is discussed along with the necessity of further studies on the principles of interaction in the endocrine system using morphofunctional analysis.

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PubMedDate not supplied

[Effect of sealed chamber conditions on the functional state of the human adrenal cortex (based on data from a study of the 11-hydroxycortico-steroid content in the blood plasma)].

The effect of a changed atmosphere, hypoxia, hypercapnia, their combinations and different motor activities on the adrenocortical function was studied in 36 test subjects kept in an 8 m3 altitude chamber. Human adaptation to the environmental changes developed with an active involvement of the adrenal cortex. The level and direction of the changes depended on both the force of the influences and on the initial state of the test subjects.

11-Hydroxycorticosteroids↗
PubMed1979

[Hormone and mediator content in the blood of the adrenals and in the peripheral blood in hypertension].

The concentration of the fractions of corticosteroids, aldosterone, catecholamines, and cyclic nucleotides (cAMP and cGMP) in blood of the adrenal veins and the activity of renin in blood of the renal veins were studied in 22 patients with stages IIA and IIB hypertensive disease. At the same time the content of these substances in the peripheral blood was determined and compared with the level of steroid and catecholamine excretion in the daily urine. An increase in the content of free 11 OCS and F fractions in the peripheral blood and blood of the adrenal veins was revealed in all patients examined.

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PubMedDate not supplied

[The character of functional connections in the endocrine system of female white rats and their transformation with age].

The authors studied the functional interrelations between the adrenal glands and the thyroid gland of female albino rats of various age groups. Blood content of 11-oxycorticosteroids and protein-bound iodine was determined. Analogous determinations were carried out in partial exclusion of the adrenal gland function (metapyron block) and of the thyroid gland function (6-methyluracil block). It is supposed that in the young sexually-mature female albino rats the functions of the adrenal glands and the thyroid gland were in direct relationship irrespective of the cyclic variations in the sex steroid secretion; with the advance of age this association became deranged.

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PubMed1976

[Activity of adrenal cytoplasmic dehydrogenase following prolonged ACTH administration].

The activity of cytoplasmic dehydrogenases of the adrenal cells was examined during the prolonged injections of ACTH to Wistar rats. The indices of specific steroid synthesis function of the glands remained relatively high in the course of the whole experiment. Changes in the rats of corticosterone synthesis and dehydrogenase activities were phasic in character; they included an initial synchronic activation the first two days with its subsequent decrease (7 days of ACTH injections). The prevalence of activities of NADP-dependent dehydrogenases in combination with reactivation of steroidogenesis was marked during the concluding phase (13 days) of the experiment. A possibility of the adaptive role of selective activation of NADP-dependent enzymes in the maintenance of a high level of hormone biosynthesis under conditions of prolonged ACTH stimulation is discussed.

11-Hydroxycorticosteroids↗
PubMed1976

[Effect of long-lasting noise on the plasma concentration of catecholamines, glucocorticosteroids and PBI in pigs].

Exposure of pigs with a body mass of 25-30 kg to long-lasting motor noise (108 dB, 60-8000 Hz, 72 hours) results in a considerable increase of catecholamine concentration in the plasma. Coincidently there is a sharp continuous decrease of the 11-OHKS in the plasma during the whole period of exposure to noise. Immediately after stopping the acoustic irritation the concentration of plasma corticosteroids increases again. The electroencephalogram (EEG) giving evidence of inhibition signs during exposure to noise an adaptation effect of the information processing system is concluded. The increase of the PBJ during the period of acoustic stress points to an increased function of the thyroid gland but simultaneously it is considered to be an expression of the elevated adrenergic situation. By reason of the strong deviation of the three observed regulatory systems must be concluded that longer-lasting exposure to noise with the applied quality and intensity represents a stress situation for pigs having noise character as established for men. A possible influence on the productivity of the pork type pig by permanent acoustic stress is indicated.

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PubMed1977

[Indices of lipid metabolism, thyroid gland and adrenal cortical function in prolonged stress of the central nervous system in chronic stimulation of the adrenals].

The experiments were conducted in 14 male rabbits dynamically on the 5th, 10th, 20th, 30th, 40th, 60th and 80th day of the central nervous system tension or at rest, including the studies of lipid metabolism (total cholesterol and beta-lipoproteins content), the function of the thyroid gland (protein bound iodine content) and the function of the adrenal cortex (11-OCS content). Such lasting stimulation of the adrenal cortex was found to be accompanied by hypercholesterolemia, hyper-beta-lipoproteinemia, elevated 11-OCS level and lack of thyroid function changes. A lasting tension of the central nervous system against the background of chronic stimulation of the adrenals delays the development of hypercholesterolemia and hyper-beta-lipoproteinemia, reduces the function of the thyroid gland, and increases the function of the adrenal cortex. The observed shifts in the lipid metabolism may be of atherogenic importance. The obtained data may be useful for the study of the pathogenesis of hormonal shifts in atherosclerosis.

11-Hydroxycorticosteroids↗
PubMed1978

[Glucocorticosteroid, catecholamine and protein-bound iodine (PBI) plasma levels in swine following electrocutaneous stimulation].

Application of electrocutaneous stimuli for short-time excitation of swine, accompanied by high locomotor activity, led in animals weighing between 30 kg and 45 kg to steep rises of catecholamine and glucocorticosteroid plasma concentrations, while little change was recordable from protein-linked iodine. Increase in plasma glucose and RQ in animals with higher rises in plasma-borne catecholamines and glucocorticoids was higher than that in animals with lower catecholamine deflection. Both the results reported in this paper and findings obtained from other studies into swine are likely to suggest major involvement of the sympathico-adrenomedullary system in the buildup of transport stress. Interdependence was found to exist between the intensity of the adrenergic reaction, on the one hand, and rises in plasma glucose and RQ as well as drop of pH, on the other. Those findings from various tests seem to support the conclusion that under conditions of severe excitation and high locomotor activity the differentiated resistance of swine to stress is atributable to different intensities of sympathico-adrenergic reaction of the animal concerned.

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