[Failure of chemoprevention with mefloquine in western Africa].
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During the last 10 years, 17 children with transposition of the great arteries (TGA) were admitted to the Cardiology Institute of Abidjan: 1 case between March 1978 and December 1985, 16 cases between January 1986 and December 1989. The average age was 58 days (range 5 to 270 days) at the first consultation, and 90 days (5 to 270 days) at the time of admission. The diagnosis was confirmed by echocardiography and hemodynamic investigation in 12 cases. There were 9 simple forms of TGA, 7 with ventricular septal defects (VSD) and 1 with VSD and pulmonary stenosis. Two children were taken back by their parents before any treatment was given. A Rashkind atrial septostomy was carried out in 11 children which increased aortic oxygen saturation from 35 +/- 18 percent to 57 +/- 19 percent; there were 3 unsuccessful procedures in children aged 2, 3 and 5 months with 2 deaths. Five patients later underwent surgical correction by a Senning procedure in 4 cases and anatomical correction in 1 case with VSD. All are well after an average 15 months follow-up (1 to 48 months). One of the 8 children awaiting surgery died. Therefore, TGA is not a rare abnormality in Black Africa; it represents 2 percent of the 887 cases of congenital heart disease observed during the same period. The inadequacy of means of diagnosis is certainly the cause of the relatively low incidence of this malformation, of the considerable delay in under specialist care and, as a consequence, of the greater difficulties in treatment, especially with regards to atrial septostomy.(ABSTRACT TRUNCATED AT 250 WORDS)
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The authors report 10 cases of Hb C Ziguinchor share out in 3 features ACz, SCz, Cz-PHHF (HPFH: hereditary persistence of foetal hemoglobin). The clinical and hematological study of the features has allowed the following conclusions: the Hb Cz is a rare mutant specific of the Negro and which original focus may be in Senegal. The heterozygote form (ACz) does not present any clinical manifestation. The association Hb S-Hb Cz brings about a serious hemoglobinopathy which has clinical and hematological features like the sickle cell disease (SS). The association Hb Cz-HPFH is relatively supported in spite of episodic painful crisis.
A serosurvey of Rift valley fever virus infection has been conducted among 2,410 domestic ruminants (sheep, goats and cattle) from Burkina Faso in 1985, 1986 and 1987. An active circulation of virus was demonstrated and 26.7% of the total animal tested had Rift valley fever virus reacting antibodies. An epizootic was demonstrated retrospectively for 1987 and appears to correspond to the RVF outbreak observed in the same type of sahelian environment during the same year in Mauritania. Analogous ecoclimatic and environmental risk factors are discussed. Others phleboviruses such as Arumowot, Gordil, Saint-Floris, Gabek Forest and Odrenisrou seem to be active in some areas but no evidence of pathogenesis for domestic ruminants was demonstrated.
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Opening an epidemiological survey of a focus of cutaneous leishmaniasis in the Thies region (Senegal), the authors present a short historical report on the disease situation in the country. They then describe the ecological characters of the studied area.
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Westerners visiting Africa for the first time are often surprized --if not shocked--at the large number of beggars in the streets and the relative ease with which people solicit or give help although pure adherents of Islam are in favour of restricting beggary . A first reason for this is that most West African societies are deeply Islamized and that begging is a characteristic feature of Islamic societies. But a closer look at the traditional structures shows that the ancestral principle of mutual solidarity is also at the basis of most people's attitude. However, the increasing number of beggars and forms of begging have turned the phenomenon into a national concern. Senegalese novelists and film-makers, even Senegalese members of the Parliament often engage in debates about that national plague and what to do about it. This paper analyzes the various motives for begging and giving alms and discusses youth's attitude towards the issue. Its tentative conclusion is that despite the overall acceptance of the phenomenon for religious reasons--a position of principle--there are clear indications of an increasingly critical attitude towards begging .
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BACKGROUND: Surveys of skin disorders have previously provided information about the prevalence and incidence of psoriasis in sub-Saharan Africa; however, the geographic and ethnic trends which may be drawn from these surveys have not been fully described in previous studies, which considered only a fraction of the available data. METHODS: A critical review of clinic-based surveys of psoriasis incidence and population-based studies of psoriasis prevalence is presented. The incidence of psoriasis is adjusted, wherever possible, to factor out the widely variable incidence of infectious skin conditions seen in African skin clinics. To distinguish between genetic and environmental factors that may be responsible for the variability of psoriasis incidence, attention is drawn to climate, human leukocyte antigen (HLA) frequencies, and language groups across the regions surveyed in sub-Saharan Africa. RESULTS: Higher psoriasis incidence rates are consistently observed in eastern Africa than in western Africa, consistent with more limited data on the prevalence of psoriasis in western Africa. Neither rainfall/humidity levels nor HLA frequencies can simply account for these differences; however, the ethnicities of sub-Saharan African peoples may be observed to parallel roughly the trend in psoriasis incidence. Western African countries, such as Nigeria, Mali, Senegal, and Sierra Leone, where lower rates of psoriasis incidence have been reported (less than 1.0% of skin disorders), are populated mainly by non-Bantu-speaking ethnic groups. Bantu-speaking peoples constitute a majority in the populations of most countries in eastern and southern sub-Saharan Africa, where the incidence of psoriasis varies widely. African Americans, whose largely non-Bantu-speaking African ancestry is shared with modern western Africans, also have relatively low psoriasis incidence rates by comparison with North American Caucasians. CONCLUSIONS: Ethnic correlations both within Africa and between North America and Africa suggest that unidentified genetic factors, which differ between eastern and western sub-Saharan Africans, may govern the differential incidence of psoriasis.