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PubMed2006

Gender differences in the relative age effect among US olympic development program youth soccer players.

A large body of research has shown that a disproportionate number of elite youth male soccer players competing in age-segmented competition are born early in the selection year. The advantage of being born early in a cohort has been termed the "relative age effect". Although there has been an exponential growth in women's soccer, few studies have examined the relative age effect in female youth soccer. This study compared the relative age effect of 1,344 female and male youth soccer players considered by the US Olympic Development Program (ODP), in 2001, to be the most talented soccer players born in 1984. The birth dates were taken from the women's state and regional ODP, and national team rosters, and were analysed using basic descriptive statistics and chi-square tests. Results revealed only a marginal relative age effect for female ODP regional and national team players and no relative age effect for female ODP state team players. In comparison, a strong relative age effect was found in male state, regional and national team players. The results suggest that there are gender differences in the relative age effect of 17-year-old elite female and male soccer players. The gender differences may be explained by a complex interaction of biological and maturational differences with socialization influences.

Adolescent↗
PubMed2006

Lessons learned from LNG safety research.

During the period from 1977 to 1989, the Lawrence Livermore National Laboratory (LLNL) conducted a liquefied gaseous fuels spill effects program under the sponsorship of the US Department of Energy, Department of Transportation, Gas Research Institute and others. The goal of this program was to develop and validate tools that could be used to predict the effects of a large liquefied gas spill through the execution of large scale field experiments and the development of computer models to make predictions for conditions under which tests could not be performed. Over the course of the program, three series of LNG spill experiments were performed to study cloud formation, dispersion, combustion and rapid phase transition (RPT) explosions. The purpose of this paper is to provide an overview of this program, the lessons learned from 12 years of research as well as some recommendations for the future. The general conclusion from this program is that cold, dense gas related phenomena can dominate the dispersion of a large volume, high release rate spill of LNG especially under low ambient wind speed and stable atmospheric conditions, and therefore, it is necessary to include a detailed and validated description of these phenomena in computer models to adequately predict the consequences of a release. Specific conclusions include: * LNG vapor clouds are lower and wider than trace gas clouds and tend to follow the downhill slope of terrain due to dampened vertical turbulence and gravity flow within the cloud. Under low wind speed, stable atmospheric conditions, a bifurcated, two lobed structure develops. * Navier-Stokes models provide the most complete description of LNG dispersion, while more highly parameterized Lagrangian models were found to be well suited to emergency response applications. * The measured heat flux from LNG vapor cloud burns exceeded levels necessary for third degree burns and were large enough to ignite most flammable materials. * RPTs are of two types, source generated and enrichment generated, and were observed to increase the burn area by a factor of two and to extend the downwind burn distance by 65%. Additional large scale experiments and model development are recommended.

Accidents↗
PubMed1994

Assessment of the US diet in national nutrition surveys: national collaborative efforts and NHANES.

The National Nutrition Monitoring and Related Research Program includes conducting national surveys to estimate the dietary intake and nutritional status of the US population. As part of this program, a 10-y comprehensive plan has been developed to strengthen nutrition-monitoring efforts in the United States. Emphasis is placed on improving coordination and comparability among data collection methods across federal agencies and on conducting relevant research. Current collaborative efforts between the US Departments of Health and Human Services (DHHS) and Agriculture (USDA) include coordinating the national food-consumption surveys in the areas of planning population coverage, by using comparable dietary intake methods, and targeting research toward improving dietary methods. The National Health and Nutrition Examination Survey (NHANES) contributes population data on diet, nutritional status, and health outcomes to the Nutrition Monitoring Program. The third NHANES (1988-1994) includes 40,000 noninstitutionalized people aged > or = 2 mo and oversamples blacks, Mexican Americans, children, and elderly people and uses an automated 24-h recall as the primary dietary instrument. Assessing dietary intake in heterogeneous populations in national surveys poses many methodologic, statistical, and interpretive issues and highlights the need for specific research to improve dietary assessment methods.

Adolescent↗
PubMed2000

Results of a survey on educational and research programs in complementary and alternative veterinary medicine at veterinary medical schools in the United States.

OBJECTIVE: To document educational and research programs in complementary and alternative veterinary medicine (CAVM) at US veterinary schools and to develop recommendations for additional curriculum development and research in these modalities. DESIGN: Mail questionnaire. SAMPLE POPULATION: Deans, curriculum committees, and interested faculty at US veterinary schools. PROCEDURES: Questionnaires were mailed to personnel at all 27 US veterinary schools. Nonrespondents received a follow-up letter and telephone contact. Information was used to establish the current status of CAVM. RESULTS: Responses were received for 41 of 120 (34%) questionnaires. Responses were received from 23 of 27 veterinary schools, but number of respondents varied at each institution (range, 1 to 4) and some surveys were not complete. Seven of 27 US veterinary schools had an educational program in CAVM. Thirty-six (87%) respondents believed that acupuncture, nutraceuticals, nutritional supplements, and physical therapy should be included in the curriculum, 25 (61%) indicated that botanical (herbal) medicine should be included, and 25 (61%) believed that chiropractic should be included. Only 17 (44%) respondents believed that homeopathy should be included. The majority of respondents believed that CAVM should be offered as elective courses. Research in CAVM has been conducted at 6 responding schools. CONCLUSIONS: Currently, few veterinary schools offer educational or research programs in CAVM. Veterinary schools are aware of the interest in CAVM and acknowledge a lack of educational and research programs in these areas. More veterinary schools are in the process of developing educational and research programs in various aspects of CAVM.

Animals↗
PubMed2004

Malaria chemotherapy and the "kaleidoscopic" organisation of biomedical research during world war II.

The paper describes the organisational and scientific evolution of the US antimalarial program during World War II. This program screened some 14,000 compounds for antimalarial activity, selected atabrine as the drug of choice in 1943, and later identified chloroquine as a superior compound. It became, arguably, the largest biomedical research effort of the first half of the twentieth century, involving chemical and pharmaceutical companies, diverse university researchers, and non-profit and government laboratories. Beyond scientific research, the innovations of the wartime antimalarial program were chiefly in three areas, communication, scale and administration. The program drew on resources - intellectual, material and organisational - created in Germany by researchers at Bayer, and in the US by the Rockefeller Foundation and Institutes. The paper examines the antimalarial program as one of the formative models for later programs such as the National Institutes of Health. This account supports the claim that wartime work was essential to the development of NIH, if only because the confused and faltering structures of the early war years, 1939-1943, do not suggest that all the organisational infrastructure for large scale, multi-centre co-operative research was in place prior to World War II.

Biomedical Research↗
PubMed2001

Background and framework for ILSI's collaborative evaluation program on alternative models for carcinogenicity assessment. International Life Sciences Institute.

The willingness of the agencies involved in the regulation of pharmaceuticals to accept data from newly proposed models for carcinogenicity testing (eg, transgenic animals, neonatal rodent models, initiation-promotion models) has stimulated international interest in gaining experience and a greater understanding of the strengths and limitations of the specific models. Over a 4-year period, the International Life Sciences Institute (ILSI) Health and Environmental Science Institute (HESI) has coordinated a large-scale collaborative research program to help to better characterize the responsiveness of several models proposed for use in carcinogenicity assessment. The overall objective of this partnership among industry, government, and academic scientists was to evaluate the ability of these new models to provide useful information for human cancer risk assessment. This research program reflected a commitment of nearly US$35 million by over 50 industrial, govemment, and academic laboratories from the United States, Europe, and Japan. Evaluation of the models required the development of standardized protocols to allow reproducibility and comparability of data obtained across multiple laboratories. Test compounds were selected on the basis of mechanistically meaningful carcinogenic activity or noncarcinogenicity in the rodent bioassay as well as humans. Criteria were established for dose selection, pathology review, quality control, and for evaluation of study outcome. The database from these studies represents an important contribution to the future application of new models for human cancer risk assessment. Beyond the data, the collaborative process by which the models were evaluated may also represent a prototype for assessing new methods in the future.

Academies and Institutes↗
PubMed1984

[Adriamycin and its analogs].

Among the biologically active metabolites produced by Streptomyces peucetius adriamycin (syn. doxorubicin) appeared the most effective anthracycline. Because of the low yield of the biosynthetic process, the chemical conversion of daunorubicin to adriamycin represent the key-step of the development of the drug. The therapeutic importance of adriamycin prompted us to begin since 1972 a research program aimed to the development of the second generation anthracyclines. The studies carried out during this research program allowed to discover three new synthetic anthracyclines, which, for the time being, are under clinical investigation: 4'- epidoxorubicin ( epirubicin ), 4-demethoxydaunorubicin ( idarubicin ) and 4'-deoxydoxorubicin ( esorubicin ). These compounds, like daunorubicin and doxorubicin, show affinity to DNA, but some of their pharmacological properties and metabolism in animals as well as in humans are different in respect to those of the parent drugs. Herein the stages of the search for new analogs and the outlooks of further progress in the filed of the antitumor anthracyclines are shortly reported.

Animals↗
PubMed2004

Analysis and prediction of traffic fatalities resulting from angle collisions including the effect of vehicles' configuration and compatibility.

Although the rapid growth in light truck vehicle (LTV) sales, including minivans, sports utility vehicles (SUVs), and light-duty trucks, has not been associated with an overall increase in collisions or traffic deaths in the US, there is a need for a research program to determine whether particular types of collisions have become more frequent or injurious because of the increase in the percent of LTVs in traffic. This paper presents an analysis of the effect of the increasing number of LTV registrations on fatal angle collision trends in the US. The analysis investigates the number of annual fatalities that result from angle collisions as well as collision configuration (car-car, car-LTV, LTV-car, and LTV-LTV). The analysis uses the Fatality Analysis Reporting System (FARS) crash databases covering the period 1975-2000. Results showed that death rates differ based on the collision configuration. Time series modeling results showed that fatalities in angle collisions will increase in the next 10 years, and that they are affected by the expected increase in the percentage of LTVs in traffic. Forecast showed that the total number of annual deaths is expected to reach 6300 deaths by the year 2010 (an increase of 12% over 2000). Analysis into the configuration of the collision indicated the seriousness of angle collisions involving an LTV striking a common passenger car (LTV-car). A time series model illustrated the significance of time lag and percent of LTVs in traffic on the increase of this type of fatal collisions. Forecasts from the time series model indicated a 32% increase in deaths due to this type of collisions in the next 10 years.

Accidents, Traffic↗
PubMed2004

[Environment and pediatric cancer].

BACKGROUND: Cancer is the final result of the variable combination of two determinants: endogenous or constitutional factors and exogenous or environmental factors. Between 85 % and 96 % of pediatric cancers (PC) are probably associated with environmental risk factors (RF), most of which have not been identified. The spectacular progress made in survival in PC contrasts with the lack of knowledge of the RF implicated in its etiopathogenesis. OBJECTIVE: 1) To analyze up-to-date knowledge of the interaction among environmental RF in the etiopathogenesis of PC, and 2) to inform pediatricians of the "Environment and Pediatric Cancer" research project directed by the Pediatric Environmental Health Specialty Unit of the Hospital Infantil Universitari La Fe in Valencia (Spain). MATERIAL AND METHODS: Current medical records focus almost exclusively on the diagnosis and treatment of cancer. The Pediatric Environmental Medical Record will contain the validated items required to document and presence or absence of endogenous and exogenous RF associated with PC described in the literature, as well as the main human cancerogenic agents identified by the International Agency for Research on Cancer and the US National Toxicology Program. RESULTS: The project aims to determine the frequency of endogenous and exogenous RF associated with PC in Spain. This project will enable hypotheses to be formulated for future epidemiologic case-control and cohort studies in Spain and other European countries, thus stimulating the introduction of educational and preventive policies in the Spanish population. CONCLUSIONS: The project requires the aid of all hospital and non-hospital pediatricians involved in pediatric cancer in informing parents and offering them the possibility of voluntarily collaborating in the "Environment and Pediatric Cancer" project by contacting the Pediatric Health Specialty Unit (Unidad de Salud Medioambiental del Hospital Infantil La Fe de Valencia [www.pehsu.org]). The collaboration of our colleagues will be essential in gaining greater insight into the RF associated with PC and in achieving prevention in the medium and long term.

Adolescent↗
PubMed2004

Designing an effective federal biomass program.

This article addresses two questions: Has the effectiveness of the US government's federal research and development (R&D) spending suffered from the post-1980 strategic change from freely shared and publicly owned to privately owned scientific advances? What criteria would a federal R&D program use to design a strategy that most effectively enhances the wellbeing of farmers and rural communities? Several studies found that the pre- 1980 US Department of Agriculture research strategy was very effective. No comparable studies have analyzed the comparative effectiveness of the post- 1980 strategy of restricting access to the results of public research. Recent experience and several analytical studies suggest that to significantly enhance the health of rural economies from an expanded use of plant matter as an industrial material, federal policy should channel scientific and engineering research into small- and medium-sized production and processing technologies and should encourage farmer-owned, value-added enterprises.

Agriculture↗
PubMed2005

Launching a new fellowship for medical students: the first years of the Doris Duke Clinical Research Fellowship Program.

As part of its commitment to increasing the pipeline of physicians pursuing careers in clinical research, the Doris Duke Charitable Foundation launched the Doris Duke Clinical Research Fellowship (CRF) Program for medical students in 2000. The program, which is based at 10 US medical schools, provides medical students from any US medical school with the opportunity to spend 1 year obtaining both didactic and "hands-on" mentored clinical research experience. This article describes the program and summarizes the early outcomes collected during the first 3.5 years of the program. Interest in the program among medical students has been robust and widespread, with 35% of CRF program fellows matriculated at non-CRF schools. Exit surveys of the first three classes of fellows totaling 174 fellows indicated that (1) 97% of the fellows felt that participating in the fellowship was a good decision; (2) commitment to a career in clinical research was increased among the 44% of fellows reporting that they were unsure about pursuing a clinical research career when they began their fellowship; (3) there was no difference in satisfaction level between the fellows who remained at the medical schools in which they were matriculated and those who completed their fellowship at a medical school in which they were not matriculated; and (4) the majority of fellows responded that the didactic component of their fellowship was useful.

Biomedical Research↗
PubMed1999

Chromium.

Chromium occurs primarily in the trivalent state (III), which is the most stable form, or in the hexavalent state (VI), which is a strong oxidizing agent. Elemental chromium (0) does not occur naturally on earth. Trivalent chromium (III) is an essential trace metal necessary for the formation of glucose tolerance factor and for the metabolism of insulin. Commercial applications of chromium compounds include tanning (III), corrosion inhibition, plating, glassware-cleaning solutions, wood preservatives (VI), manufacture of safety matches, metal finishing (VI), and the production of pigments (III, VI). Hexavalent chromium (VI) contaminated local soil when chromium waste slag was part of the fill material present in residential, public, and industrial areas. In some urban areas, about two-thirds of the chromium in air results from the emission of hexavalent chromium from fossil fuel combustion and steel production. The remaining chromium in air is the trivalent form. The residence time of chromium in air is < 10 days, depending on the particle size. Trivalent compounds generally have low toxicity and the gastrointestinal tract poorly absorbs these compounds. Hexavalent chromium is a skin and mucous membrane irritant and some of these hexavalent compounds are strong corrosive agents. Hexavalent chromium compounds also produce an allergic contact dermatitis characterized by eczema. Sensitivity to trivalent compounds is much less frequent, but some workers may react to high concentrations of these compounds. Hexavalent chromium is recognized by the International Agency for Research on Cancer and by the US Toxicology Program as a pulmonary carcinogen. The increased risk of lung cancer occurs primarily in workers exposed to hexavalent chromium dust during the refining of chromite ore and the production of chromate pigments. Although individual studies suggest the possibility of an excess incidence of cancer at sites outside the lung, the results from these studies are inconsistent.

Animals↗
PubMed1996

Advice for beginning nurse researchers.

Heideggerian hermeneutics was used to illuminate the advice of six nurse researchers who were interviewed by the authors. The advice given to us as beginning researchers included identifying a planned program of research with a topic that we "love" and conducting research that is meaningful. Additional advice included keeping an idea log, networking, mentoring, and developing collegial relationships. The words of these researchers are intended for future investigators, yet much wisdom exists for all nurses.

Documentation↗
PubMed2006

Building capacity for tobacco control research and policy.

The Fogarty International Center (FIC) initiative, "International Tobacco and Health Research Capacity Building Program" represents an important step in US government funding for global tobacco control. Low- and middle-income countries of the world face a rising threat to public health from the rapidly escalating epidemic of tobacco use. Many are now parties to the Framework Convention on Tobacco Control (FCTC) and capacity development to meet FCTC provisions. One initial grant provided through the FIC was to the Institute for Global Tobacco Control (IGTC) at the Johns Hopkins Bloomberg School of Public Health (JHSPH) to support capacity building and research programmes in China, Brazil, and Mexico. The initiative's capacity building effort focused on: (1) building the evidence base for tobacco control, (2) expanding the infrastructure of each country to deliver tobacco control, and (3) developing the next generation of leaders as well as encouraging networking throughout the country and with neighbouring countries. This paper describes the approach taken and the research foci, as well some of the main outcomes and some identified challenges posed by the effort. Individual research papers are in progress to provide more in-depth reporting of study results.

Brazil↗
PubMed1986

Comparison of nutrient intakes of selected populations in the United States and Israel: the Lipid Research Clinics prevalence study.

Nutrient intakes of 2,772 US and 2,680 Jerusalem participants of the Lipid Research Clinics Program were assessed by 24-h dietary recall in men aged 15-19 and 40-59 yr and women aged 15-19 and 35-59 yr. Energy intake was higher in the US than in Jerusalem. In Jerusalem intake of total fat ranged between 32.2-33.7% of kcal, of saturated fatty acids (SFA) between 9.8-10.9%, of polyunsaturated fatty acids (PFA) between 7.9-8.6%, of carbohydrates between 50.5-53.9%, and of starch between 24.0-30.5%. The P:S ratio ranged between 0.80 and 1.01. The corresponding ranges for the US were 38.8-40.8% for fat, 14.3-15.9% for SFA, 5.9-6.8% for PFA, 38.9-46.2% for carbohydrates, 17.0-17.9% for starch, and 0.40-0.53 for the P:S ratio. Intake of cholesterol (mg/1000 kcal) was higher in Jerusalem than in the US. These data address the feasibility of reducing fat in diets of free-living, Western populations.

Adolescent↗
PubMed1976

A comparative study of art expression of schizophrenic, unipolar depressive, and bipolar manic-depressive patients.

The literature on art productions from psychiatric patients consistently suggests that specific graphic characteristics distinguish among various major diagnostic groups. These hypothesized differences are summarized. Systematic collection of art productions as part of separate research programs studying affective psychoses and schizophrenia has enabled us to amass a collection of psychotic patients' drawings which are used in an attempt to evaluate these hypotheses empirically. Art sessions were held with 104 patients hospitalized for affective psychoses and with 62 patients hospitalized for acute schizophrenia at NIH's Clinical Center. Comparing these drawings across diagnostic groups revealed, to our surprise and contrary to extant hypotheses, considerable within-diagnostic group variability and between-group overlap. There were, nonetheless, some trends in the hypothesized directions. These differences, however, disappeared when comparisons were made on a subsample of age-matched patients. This discrepancy between this research and expectations based on the literature is discussed. Our studies indicate that pictorial characteristics are not closely associated with diagnosis. We have, however, found that individual patient's art productions, and their associations to the pictures, are of great value in arriving at a dynamic understanding of the patient, regardless of diagnosis.

Age Factors↗
PubMedDate not supplied

Lessons learned from Mir--a payload perspective.

Among the principal objectives of the Phase 1 NASA/Mir program were for the United States to gain experience working with an international partner, to gain working experience in long-duration space flight, and to gain working experience in planning for and executing research on a long-duration space platform. The Phase 1 program was to provide the US early experience prior to the construction and operation of the International Space Station (Phase 2 and 3). While it can be argued that Mir and ISS are different platforms and that programmatically Phase 1 and ISS are organized differently, it is also clear that many aspects of operating a long-duration research program are platform independent. This can be demonstrated by a review of lessons learned from Skylab, a US space station program of the mid-1970s, many of which were again "learned" on Mir and are being "learned" on ISS. Among these are optimum crew training strategies, on-orbit crew operations, ground support, medical operations and crew psychological support, and safety certification processes.

Aerospace Medicine↗