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PubMed1994

Studies of aloe. IV. Mechanism of cathartic effect. (3).

Charcoal transport, as an indicator of the degree of peristalsis, and water content in the large intestine after the intracaecal administration of barbaloin, were measured simultaneously in the same rat. Charcoal transport was significantly accelerated at both 3.5 and 6.5 h after the administration of barbaloin. At 6.5 h, diarrhea instead of normal faeces was observed. Moreover, at 1 h before the acceleration of charcoal transport, a marked increase in the relative water content of the large intestine was observed. It appears that the increase in water content of the large intestine induced by barbaloin precedes the stimulation of peristalsis, attended by diarrhea. Therefore, it is suggested that the increase in water content is a more important factor than the stimulation of peristalsis in the diarrhea induced by barbaloin.

Aloe↗
PubMed1990

Studies of aloe. III. Mechanism of cathartic effect. (2).

The mechanism of action of aloe-emodin-9-anthrone, a decomposition product of barbaloin, in causing a significant increase in the water content of the rat large intestine, was investigated. Aloe-emodin-9-anthrone inhibited rat colonic Na+, K(+)-adenosine triphosphatase (ATPase) in vitro, and increased the paracellular permeability across the rat colonic mucosa in vivo. Therefore, it seemed that the increase in water content of the rat large intestine produced by aloe-emodin-9-anthrone was due to both inhibition of absorption and stimulation of secretion without stimulation of peristalsis. Furthermore, pretreatment with loperamide, an antidiarrheal agent, completely prevented the increase of paracellular permeability induced by aloe-emodin-9-anthrone but did not completely reduce the concomitant increase in residual fluid volume. These findings suggest that aloe-emodin-9-anthrone has multiple mechanisms of action involved in the increase of water content in the rat large intestine.

Aloe↗
PubMed2005

Hypermagnesemia induced by massive cathartic ingestion in an elderly woman without pre-existing renal dysfunction.

A 76-year-old woman was referred to our hospital for unresponsiveness and hypotension. She had developed constipation that had led to ileus and had received 34 g of magnesium citrate (Magcolol P) orally the day before. She was lethargic, her blood pressure was less than 50 mmHg, and electrocardiogram (ECG) revealed sinus arrest with junctional escape rhythm. Her serum concentration of magnesium (Mg) was markedly elevated (16.6 mg/dl =13.7 mEq/l). Emergency colonoscopy revealed ischemic colitis. As her condition ameliorated, her renal function returned to normal. Hence, the present case suggests that severe hypermagnesemia can occur in the absence of pre-existing renal dysfunction in elderly patients with gastrointestinal diseases.

Administration, Oral↗
PubMed1975

Cathartics.

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Cathartics↗
PubMed1998

How do cathartic drugs act? A case study on Gregor Horst (1578-1636) and his attempt to defend Galenist theory.

This case study deals with the argument of the Galenist author Gregor Horst (1578-1636), Medical Professor at Giessen University, Germany, and later town phyusician in Ulm, in the discussion on how purgatives act. Horst tried to reconcile a number of different opinions within a Galenist framework. His vast erudition enabled him to compare several classical as well as contemporary opinions. He takes into account Galen (129-c.200/216), Erasistratos (c. 330-255 BC), Asclepiades (fl. 1st century BC), the Hippocratic Corpus and the Problemata Aristotelis from antiquity, Mesue and Mundinus (c. 1270-1326) from the Middle Ages, and Jean Fernel (c. 1497-1558), Girolamo Cardano (1501-c. 1576), Johannes Costaeus (d. 1603), Laurent Joubert (1529-1583), Francisco Valles (1524-1592), Tobias Dorncreilius (1571-1605) and Gavriele Falloppio (1523-1562) from contemporary authors. Horst also integrated some Paracelsian ideas from Joseph Duchesne alias Quercetanus (1549-1609). In his attempt to preserve fundamentals of Galenic thought, Horst created a complicated theory nearly breaking under its own weight. He shows a rising divergence within traditional views as well as the fragmentation of Renaissance Galenism which took place already before the discovery of the blood circulation.

Cathartics↗