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At least 109 records · Page 6Linked to original sources
PubMed2006

Expression of endothelial leukocyte adhesion molecule 1 in the aqueous outflow pathway of porcine eyes with induced glaucoma.

PURPOSE: To determine if the expression of endothelial leukocyte adhesion molecule 1 (ELAM-1) in the trabecular meshwork system of the porcine eye, when subjected to experimental glaucoma, is increased as it does in human glaucoma. METHODS: Immunohistochemistry using a specific mouse antihuman ELAM-1 antibody was performed on the trabecular meshwork system of five pigs. The episcleral veins of the left eyes were cauterized as reported elsewhere to induce glaucoma. Immunodetection of ELAM-1 was assayed in human trabecular meshwork samples obtained from trabeculectomy as a positive control. RESULTS: Pig eyes exhibiting elevated intraocular pressure (IOP) and damage to retinal ganglion cells (RGCs) due to experimental glaucoma as reported elsewhere, were found to exhibit ELAM-1 immunoreactivity in their trabecular meshwork. CONCLUSIONS: ELAM-1 protein, the first molecular marker for human glaucoma, can also be considered a candidate molecular marker of induced glaucoma in the pig model of experimental glaucoma. The results of our study further validated the pig eye as an animal model of glaucoma, since increased expression of ELAM-1, which has been found in the trabecular meshwork of human eyes with glaucoma, is also found in pig eyes subjected to experimental glaucoma via episcleral vein cauterization.

Animals↗
PubMed1997

Epistaxis: a retrospective review of hospitalized patients.

A 2-year retrospective study (August 1, 1992, to July 31, 1994) reviews medical records of 249 hospitalized epistaxis patients at seven Baltimore-area hospitals. This review represents the first multihospital study of patients hospitalized with epistaxis. The study evaluates multiple factors associated with epistaxis: demographics, underlying medical diseases, use of anticoagulation medication, site of epistaxis, and month of hospital admission. Blood transfusion requirement, hematocrit level, length of stay, treatment, and local/systemic complications are studied as well. The month of hospital admission was evenly distributed without a wintertime predominance, and the mean length of stay was 4 days. Treatment and outcome were similar in all hospitals, and more than 83% of patients responded to packing, balloon placement, local cautery, or a combination thereof. Of the 249 patients reviewed, 30 underwent surgical endoscopic cautery, 3 required formal surgical arterial ligation, and 1 underwent arterial embolization. All 30 endoscopic cauterizations successfully stopped the epistaxis, and this technique proved to be a useful adjunct for patients who required multiple interventions. The review identified a 3% complication rate of epistaxis and its treatment, including synechiae, aspiration, angina, myocardial infarction, and hypovolemia. No deaths were directly attributable to epistaxis or its treatment.

Adolescent↗