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PubMedDate not supplied

Climacteric-like disorders in prostate cancer patients treated with LHRH agonists.

We assessed long-term side effects with characteristics of female climacteric disorders in prostate cancer patients treated with luteinizing hormone-releasing hormone (LHRH) agonists. Such side effects are not considered to be serious, though they can significantly affect patient quality of life. Sixty-four prostate cancer patients treated with LHRH agonists and 30 benign prostatic hyperplasia patients, as a control group, were surveyed by questionnaire. The median age of the cancer patients was 74.9 years old, ranging from 60 to 94 years, and the median LHRH agonist dosing period was 16.5 months, ranging from 1 to 64 months. The results of the questionnaires were compared between the patients and the controls, as well as between different variables. Sixty (93.8%) of 64 patients claimed symptoms similar to female climacteric disorders. Further, more than 50% of the symptoms included in the questionnaire were reported by 14 (21.9%) of the patients. Symptoms reported by the patients were more severe than those by the controls. Hot flashes, sleep disturbance, and fatigue recorded high scores in the patient questionnaires as compared with those of the controls. In addition, as the term of LHRH agonist use increased, complaints of sweating or coldness in hands and feet increased. Patients without bone metastasis frequently experienced heaviness in the head and headaches compared to those with bone metastasis. The results of our questionnaire-based outcome study showed that side effects similar to female climacteric disorders in prostate cancer patients treated with LHRH agonists were more severe than in the control group, which could be detrimental to quality of life and general well-being.

Aged↗
PubMed1987

The fate of the untreated menopause.

The human female climacteric is the phase of life that marks the transition from the reproductive to the nonreproductive years. When symptoms occur, the term "climacteric syndrome" may be utilized. The purpose of this review is to demonstrate that sufficient evidence now exists to confirm that the climacteric syndrome is a specific one that can be regarded as an endocrinopathy. The statement that the human female climacteric represents a pathologic rather than a physiologic state should not generate antagonistic counter-arguments; rather, it should be recognized as a challenge for the identification, prediction, and prevention of organic disease in the woman during the climacteric and after.

Climacteric↗
PubMedDate not supplied

Climacteric complaints, female identity, and sexual dysfunctions.

Forty early menopausal women seeking relief from sexual symptoms within a long-term marital relationship and 40 matched women seeking relief of climacteric complaints completed questionnaires concerning three subject: vasomotor and psychosocial symptoms, sexual dysfunctions, and female identity. Results showed that women with sexual dysfunctions were more likely to suffer from vasomotor and psychosocial complaints and their feminine identity was based mainly on ideals of motherhood and beauty. In addition, sexual desire disorders were present significantly in those women with higher psychosocial symptoms, while sexual arousal disorders were particularly evident in women suffering more vasomotor symptoms.

Climacteric↗
PubMed1992

[Bone density screening in females in climacteric].

Bonestability is not only determined by the content but also by the construction of the mineral part and the biochemical structure. In addition the organic parts are important, too. Result of the measurements shows only the bone-quantity. The development of several measurement techniques (highquality quantitative computertomography [QCT]) allow us diagnoses concerning the bone quality. Single photon absorptionsdensitometry (SPA), DPA (dual photon absorptiometry), DEXA (dual energy X-ray absorptiometry) and QCT (quantitative computertomography, peripher and central) are todays measurement techniques. In the meantime SPA looses the importance, also DPA-method is displaced by DEXA.

Bone Density↗
PubMed1992

[Oral symptoms in the climacteric. A prevalence study].

The female climacteric is attributed to physiological ovarian failure with the consequent decrease in the secretions of oestrogen, progestones and androgens. Numerous metabolic, psychological and physical changes have been associated with this event. Oral discomfort, including the burning mouth syndrome and the dry mouth syndrome, has been described as a menopausal symptom. However, the relationship between the hormonal changes related to climacteric and the onset of oral discomfort is still controversial. The purpose of the present study was to evaluate the prevalence of oral symptoms, with particular regard to burning sensation, xerostomia, altered taste and recurrent oral ulcerations. The relationship between oral and climacteric symptoms and psychological status of the patients was also evaluated. A questionnaire was administered to 136 women (mean age: 51.2 years, range 40-62) being consecutively referred to the University Hospital Menopause Clinic from October 1991 to March 1992. The questionnaire included informations regarding menopausal state, oral symptoms, drug assumption, wearing of partial or total dentures, parafunctions (lip and cheek biting, bruxism, tongue thrusting). Climacteric symptoms including flushes/sweats, palpitations, headache, arthralgia/myalgia, vaginal dryness, decreased concentration, tiredness, decreased libido, insomnia, vertigo were evaluated. Visual analogue scale (VAS) was used where appropriate. Information regarding the alteration of the psychological status was collected by means of the Hospital Anxiety and Depression Scale Statistical analysis was performed by chi 2 test or Fisher's Exact Probability Test and Mann-Whitney U-test. The level of significance accepted was 5%. The subjects in this study were divided into two groups on the basis of their answers to the questionnaire: group I (no. 39), premenopausal women; group II (no. 97), menopausal women.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Psychosomatic aspects of females in the climacteric. The climacteric--psychosomatics--personality structure].

In this experimental study, the feelings of climacterium in two groups of menopausal women were compared (a test group with climacteric complaints vs a control group without complaints). 70 patients were given a questionnaire: EWL by Janke and Debus, FPI and Giessen-test. The evaluation of the socio-economic data exhibited the fact, that patients in the group with complaints took more drugs than the other group and were more inclined to weight gain. Gynecological data showed significant differences in the beginning and the experience of menstruation. Psychological tests of the group with complaints showed a lack of self-assurance and increased anxiety. These women had also a tendency toward psychosomatic disorders and were less assertive in their social contacts. The discriminant analysis of menopausal and personality variables classified the women equally into the group with complaints compared to the control group.

Adaptation, Psychological↗
PubMed1980

Historical perspective: Tilt, E.J. and the change of life (1857)--the only work on the subject in the english language.

Tilt was the author of the only English book on the female climacteric published in the 19th century. This short historic sketch is primarily concerned with the evaluation of his work. It only hints at the differences between conditions on the opposite sides of the English Channel which encouraged the expression of climacteric disturbances to the south of it but not to the north. Though Tilt acted as an agent of diffusion for the medical concepts developed in France he had hardly any listeners. During the last quarter of the century, however, conditions changed greatly increasing stress among women. The work of Tilt then supplied a ready mould into which the many nebulous complaints presented by women could be fitted. Ménopause became anglicized to menopause: but though Tilt was "vindicated" he was also forgotten. His style was dated and his treatment out of date. His strong advocacy of sedation is still followed but his pioneering of statistical investigation of the climacteric is largely forgotten. Endocrinal research has made us neglect all that happened before it; examination of the past, its achievements and mistakes, may yet, however, teach us a great deal.

Climacteric↗
PubMed1981

Oral complaints related to climacteric symptoms in oöphorectomized women.

Numerous oral complaints have been attributed to the female climacteric including altered taste, a burning sensation and xerostomia. However, the data relating these symptoms to the climacteric require elucidation as there have been no adequately controlled studies. In the present investigation, a group of 145 oöphorectomized women were followed for one year. Approximately half were treated with oestrogen replacement and the remainder with a placebo. The results indicate that the hormone had no direct effect upon the oral symptoms but that there was a general increase in somatic complaints which appeared to be related to the degree of neurosis experienced. This is turn can be attributed to vasomotor changes which are under the control of oestrogen.

Adult↗
PubMed1989

[Pathogenesis of uro-gynecologic disorders in post-menopausal women].

In the pathogenesis of uro-gynaecological complaints in post-menopausal women, the effects of aging and estrogenic deprivation operate jointly to produce complex clinical conditions where numerous different factors are involved: neurological disorders, loss of the usual support of the pelvic organs, rigid urethral wall, atrophy of urethrovesical and genital epithelium. The Authors analyse all these factors and dwell upon mechanisms by which they lead to the various genito-urinary affections of the female climacteric.

Female↗
PubMedDate not supplied

The physiology of the perimenopausal years: a minireview.

Selected studies on the physiology of the perimenopausal years and the subtle transitional changes that occur up to the postmenopause are reviewed. Extraovarian sources of estrogen, which must be considered when recommending dosage of replacement therapy, are described. The effects of hormonal therapy on endogenous hormones and the important roles of progesterone and prolactin are highlighted. The collected evidence suggests that (a) the vasomotor disturbance and depression experienced by estrogen-deficient women are not psychosomatic disorders, (b) osteoporosis is preventable if estrogen therapy is initiated soon after cessation of ovarian function, and (c) administraton of a weak estrogen combined with a progestogen can effectively prevent or treat the difficulties experienced during the female climacteric.

Adult↗
PubMed2005

[Experimental studies on menopausal syndrome treated by traditional Chinese medicine].

In this paper, literature about experimental researches on female climacteric syndrome (FCS) treated by traditional Chinese medicine (TCM) published in recent years were reviewed. This paper reviewed not only experimental researches about the effects of nervous system-endocrine and immune regulating net work, the vegetative nervous function and free radical treated by TCM; but also concerned the experimental approaches of animal selected, model established; and objective indexes of FCS. Taking advantages of FCS by integrative medicine is available for enhancing the clinical efficacy.

Animals↗
PubMed2000

Sex differences in 'climacteric symptoms' with increasing age? A hypothesis-generating analysis of cross-sectional population surveys.

Are the established clinical symptoms of the female climacteric really specific for women? We were interested to compare the prevalence of these symptoms across age and sex. In the absence of longitudinal (cohort) studies, we tried to find cross-sectional, population-based studies with a broad age span to find a preliminary answer. We obtained six surveys that contained information for at least some of the symptoms. We re-analyzed these databases, which included over 8000 males and 8000 females, in a pooled fashion. Sixteen symptoms of predominantly somatic, psychological and urogenital origin were identified and the age-dependent increase of the relative frequencies was compared between genders. A general tendency for women to report more symptoms was confirmed; however, no significant differences were found between genders regarding the time trend of these symptoms. The analyses suggest that males experience a similar symptomatology in the same age span as women. One may thus be tempted to conclude that aging males experience similar phenomena to women during their menopausal transition. This should be confirmed in a specifically designed study.

Journal Article↗