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[Cytomegalic inclusion disease of the salivary glands in sudden infant death syndrome].

The parotid gland and/or the submandibular gland in SIDS cases (180 from Berlin und 75 cases from Hamburg) were examined by means of HE staining, immunohistochemical analysis, in situ hybridization and electron microscopy. The SIDS cases were taken from the last 10 years; the age of the children ranged from 2 weeks to 1 year. Typical cytomegaly inclusion bodies were recognized in 10% (18 cases from Berlin; more girls than boys) and 7% (6 cases from Hamburg; more boys than girls). Our files indicate that the frequency of CMV infection was not age-dependent within the first 12 months of life. Using immunohistochemical analysis and in situ hybridization, virus substances were detected in cytomegal cells as well as in morphologically uninfected cells. The literature on the clinical and epidemiological aspects of cytomegaly indicates that a localized CMV infection of the salivary glands does not sufficiently explain the sudden death of these infants; however, it should be emphasized that cytomegaly can influence the immunological status of the organism.

Cytomegalovirus↗

Cytomegalic inclusion disease diagnosed endoscopically.

Two patients who received renal transplants developed erosions or ulcers in the upper gastrointestinal tract. In both cases endoscopic evaluation enabled a diagnosis of cytomegalovirus (CMV) infection to be made quickly and safely. We emphasize the importance of early diagnosis of CMV infection and how endoscopy may be helpful.

Adult↗

[Vaccination and morbidity in Basel school-children (measles, mumps, rubella, chickenpox, cytomegalic inclusion disease)].

Antibodies against diseases of childhood have been determined in fall 1977 taking bloodsamples of 430 15-year old students. Immunity was widespread for measles (96%), chickenpox (93%), mumps (90%) whereas 27% did not have antibodies against rubella. The level of vaccination (measles, mumps, rubella) is increasing fast in younger children. The possibility of being infected by a wild virus will be low in the future for those who have not been vaccinated. Antibodies against Cytomegalovirus were measured in 120 students of normalschool and 107 "gymnasiasts". The proportion between negative and positive was 1.1 for students in normalschool and 2.7 for those attending a higher education.

Adolescent↗