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Computer graphics interface to a complex simulation.

The program "Cardio VascularCat" is a simulation of a laboratory experiment on the cardiovascular system of the cat, for students of physiology or pharmacology. There are two important innovations in this version, utilizing the "Macintosh environment": 1) The functioning of the program is highly interactive with the student. Any manipulation almost immediately produces some result in the (simulated) experimental animal. 2) The input from the student, and the output to the student, are handled in simple and intuitive ways. The mouse and menu system are utilized to simplify the control of the program. The keyboard is eliminated. The Macintosh graphics capabilities provide for an output display that is easily and quickly interpreted by the student. The program has been tested with a small sample of medical students. As measured by an objective test, the results are equivalent to learning from a textbook. An attitude survey revealed that the Macintosh program is clearly superior for reenforcement and review.

Animals

Three-dimensional computer graphic modeling of ballistic injuries.

Multiple variables affect the tissue destruction caused by missiles, and the interaction of these variables is incompletely understood. The recently developed technology of computerized solid modeling now makes it possible to analyze these parameters in three dimensions. A technique for creating solid models of organic structures is described. The tissues within the boundaries thus defined are ascribed physical attributes by means of finite element analysis with data derived from empirical studies. An interactive user-friendly program is being developed combining this modeling with a probabilistic scheme (Monte Carlo simulation) to describe a variety of wounding scenarios. The data from these predictions will be compared with information from wound registries and the model refined until it can project consistently accurate patterns of injury.

Computer Graphics

Molecular conformational space analysis using computer graphics: going beyond FRODO.

The molecular graphics program FRODO has been modified to support analytical animation of molecular dynamics trajectories. The enhanced program, mdFRODO, supports all features available in FRODO and is interfaced to GROMOS. A variety of analytical animation modes is included. Extensive coloring and atom selection features are implemented to aid the user in distinguishing features of interest in a set of conformations. Molecular conformational space can be analyzed efficiently and comprehended. Animations may be viewed in stereo, and the animated object can be overlaid with any of the standard FRODO objects. The mdFRODO program is of wide use in molecular dynamics, X-ray crystallography and two-dimensional NMR work. Examples illustrating various aspects of collective motion in protein molecules are given and discussed.

Computer Graphics

Prediction of total knee motion using a three-dimensional computer-graphics model.

Twenty-three knees were sectioned, digitized, and standardized to determine the 'average' three-dimensional bony geometry and ligamentous attachments. Data on normal knee motion were obtained from a cadaveric study. An algorithm was written to simulate three-dimensional patella motion. Verification of the knee model was achieved by determining femoro-tibial and patello-femoral contact locations, as well as ligament length patterns, and comparing the results with published data. The criterion for maximum predicted knee motion with a prosthesis in place was the length of the posterior cruciate ligament. Three total knee replacement surfaces were mathematically generated: flat, laxity and conforming. A greater flexion angle was obtained with a flat tibial surface than for the laxity or conforming. Posterior tibial component displacement increased the range of motion, but only slightly. For all tibial surfaces, increased range of motion was achieved with a 10 degrees posterior tilt of the tibial tray. Anterior femoral component displacement increased motion due to reduction in posterior cruciate tension during flexion. The results are applicable to the design and surgical technique of total knee replacement.

Algorithms

Computer graphics for slide presentations.

This applications article describes the use of a computer to generate high-quality presentation materials. Different programs and methodologies are discussed.

Computer Graphics

Hypertext and three-dimensional computer graphics in an all digital PC-based CAI workstation.

In the past several years there has been an enormous increase in the number of computer-assisted instructional (CAI) applications. Many medical educators and physicians have recognized the power and utility of hypertext. Some developers have incorporated simple diagrams, scanned monochrome graphics or still frame photographs from a laser disc or CD-ROM into their hypertext applications. These technologies have greatly increased the role of the microcomputer in education and training. There still remain numerous applications for these tools which are yet to be explored. One of these exciting areas involves the use of three-dimensional computer graphics. An all digital platform increases application portability.

Computer Graphics

VESICA: computer graphics modeling of lipid vesicles.

A vesicle simulation and computer analysis program, VESICA, is described which employs spherical projections of triangularly tessellated icosahedra to produce molecular graphics models of the three-dimensional structures of lipid vesicles. The program is used to analyze the molecular architecture of small unilamellar vesicles of dipalmitoyl-phosphatidylcholine and is demonstrated as a worthwhile investigative tool for determining the factors that govern the minimum vesicle size.

1,2-Dipalmitoylphosphatidylcholine

Computer graphics in the assessment of severity of spasmodic torticollis: potential role in the evaluation of surgical treatment.

There is a need for objective evaluation of the effectiveness of treatment of spasmodic torticollis so that comparisons can be made between different therapies. Video tape recordings of patients undergoing surgery for spasmodic torticollis were digitized and the movement of a reference marker was tracked by computer. A graphic presentation of oscillation of the marker around a mean position was obtained. Comparison of preoperative and postoperative recordings enabled assessment of the effectiveness of surgery. The results can be tabulated, facilitating accurate documentation of large series of results in publication. This should enable easier comparison of the effectiveness of different therapies.

Adult

An on-line computer graphics terminal for radiotherapy treatment planning.

A programmed graphics terminal has been connected on-line to a large time-shared computer for calculating dose distributions in radiotherapy treatment planning and provides a viable alternative to dedicated systems and batch working. The terminal equipment is based on a mini-computer and includes a function-key devise for outline input, a large-screen refresh oscilloscope for viewing results and an X-Y plotter for hard-copy. Radiotherapy dose computation programs in standard Fortran are stored and run on a large remote computer with graphical interaction at the terminal. External beam programs can calculate dose distributions for most commonly used treatment situations and can compute in off-axis planes. Data input is fully interactive and easy to understnad. Dose distributions are displayed as isodose contours. Advantages of the system include accuracy, speed, ease of use and maintenance, and transferability of the programs between different host computers.

Data Display

Computer graphic study on models of the molybdenum cofactor of xanthine oxidase.

Within the scope of our molecular modeling studies on xanthine oxidase (XOD) inhibition by purine analogs we were interested to build up a three-dimensional model of the molybdenum active site. Spectroscopic data indicated that a Mo (VI)atom which is coordinated to sulfur, oxygen and/or nitrogen is clearly involved in substrate binding. In the present study, those data and X-ray crystallography data were used to reconstruct molybdenum-organic complexes from models proposed in the literature. The computer graphic-assisted modeling and evaluation of the model complexes show that the description of the molybdenum center needs further refinement.

Binding Sites