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Results for “Computers, Mainframe”

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PubMed1992

PC-based application programs in large health care systems.

Public health care agencies lack the infrastructure to meet the increasing operational demands on them, but there is little comparative data on alternative operational structures and systems from which to formulate remedies. Improved information management systems could help address both the workload and the gathering of critically needed data. PC-based database and application programs (PC-APs) that communicate with the mainframe are proposed as a methodology for filling the information-processing gap between mainframe computing and manual information systems. We also propose a model for systematic study of information management systems in clinical settings which can be used to evaluate other aspects of clinical program operations as well. A pilot study demonstrating these methodologies suggests that this is a fruitful approach to assessing ambulatory care operations and that PC-APs can improve administrative and clinical functions and enhance FTE productivity at lower overall cost.

Ambulatory Care Information Systems↗

PubMed1991

Microprocessor based detection of epileptic discharges.

Parametric and Non-parametric methods have been developed for the detection and interpretation of EEG data for normal and abnormal patients. These methods have been implemented on mainframe computers or dedicated microcomputers. The heuristic methods are suitable for implement on dedicated microprocessor based system as they involve less degree of computation in comparison to the parametric methods. In this work a microprocessor based system has been developed and heuristic pattern recognition technique has been applied, which is based on the measurement of amplitude, duration slopes etc. for the detection of spike and sharp waves as well as the different frequency band of background activity. The computed values of amplitude and durations are shown on the graphs from which the different symptoms based on EEG are determined.

Analog-Digital Conversion↗

PubMed1995

Patient data management systems in anaesthesia: an emerging technology.

The purpose of this review is to define the expectations of an on-line automatic patient data management system (PDMS) into anaesthesia work-stations in and around the operating room suite. These expectations are based on review of available information in the medical literature, and trials of several systems that are available commercially, three of them in a more detailed fashion (i.e. Informatics, Datex and North American Drager). The ideal PDMS should: -- communicate with and capture the information from different monitors, anaesthesia machines and electronic gadgets (e.g., infusion pumps) used in the operating room (OR), while presenting selected relevant values and trends on a screen. -- inform the anaesthetist of deviations from preselected limits of physiological and technical values. In the future, the system will hopefully be upgraded to include an algorithm-based decision support system. -- communicate with the hospital mainframe computer, and automatically transfer demographic data, laboratory and imaging results, and records obtained during preoperative consultations. -- at the end of each anaesthetic procedure, create an anaesthetic record with relevant data automatically collected by the system, as well as that which was entered manually by the physician during the procedure. A copy of this anaesthesia file must be kept on a computerized archive system. None of the systems so far evaluated fulfilled all our expectations. We have therefore adopted approach for the gradual introduction of such a system into our OR environment over the next two to five years, during which expected improvements may be incorporated to upgrade the system.

Anesthesiology↗

PubMed1992

Efficacy of 131I ablation following thyroidectomy in patients with invasive follicular thyroid cancer.

The role of thyroid ablation following thyroidectomy for invasive follicular cancer remains controversial. The use of iodine 131 (131I) ablation as adjuvant therapy may facilitate follow-up of patients in whom serum thyroglobulin levels and 131I total body scans are used to detect metastatic disease. It is uncertain if 131I ablation improves survival of patients with follicular thyroid cancer. Thus, the purpose of this study was to determine if survival is enhanced following ablation, with particular reference to those patients with minimally invasive cancer. Between the years 1955 to 1988, 142 patients with invasive thyroid follicular cancer were treated at the British Columbia Cancer Agency, of whom 71 had minimal invasion and no extrathyroidal extension of tumor. In this group of patients, 46 underwent hormone suppression only, 17 had ablation, and 8 had neither. The average follow-up was 9 years and extended beyond 15 years in many patients. Data were entered in a mainframe computer, and Kaplan-Meier survival analysis was used, comparing crude survival, disease-specific survival, and disease-free survival. There was no significant difference between groups. In patients with follicular thyroid cancer and capsular invasion only, 131I ablation does not improve survival compared with patients treated with thyroid hormone suppression only.

Adenocarcinoma↗

PubMed1987

A microcomputer-based distributed data management system for a large cooperative study of transfusion associated acquired immunodeficiency syndrome.

This paper describes the details of a microcomputer-based, distributed data management system in the acquisition of data collected in a large multicentered cooperative investigation of transfusion-transmitted acquired immunodeficiency syndrome (AIDS). Clinical, virological, and immunological data are obtained from six clinical centers and six central laboratories using a variety of hardware components and software packages. Data are merged and processed on a mainframe computer at the Biostatistics Office at the University of Southern California. The advantages and disadvantages of this system are discussed relative to the dynamics of the study, the magnitude and nature of the database, and the organization of the distributed centers involved.

Acquired Immunodeficiency Syndrome↗

PubMed1996

A data management software for the Sysmex NE 8000 haematology analyser.

The Sysmex NE 8000 (TOA-Japan) is a haematology analyser that performs blood cells count and leukocyte differential count. For facilitating the work of technical validation, we developed a software adapted to any IBM or compatible PC running under MS-DOS, to manage the analyser. Data are automatically collected via the RS-232 interface from the analyser or keyed in for the other techniques. The software deals with 64 different analyses entirely "user defined". Six technical alarms of the analyser are taken in account for red or white cells and platelets. An "electronic worksheet" presents the results or alarms with 10 patients to a page. This enables the lab technician to assess the coherence of the various data and to perform verifications or complementary tests if necessary. As an option, a blinking asterisk can signal any results out of predetermined range. By moving the cursor through the table, a test result can be deleted, modified or added. A function displays the patient previous files in a window because the data are recorded in long term archives at the end of the day. This long term recording allows a search of previous files to decide additional tests if the patient is unknown. If the patient is known, with additional tests previously performed, this procedure is time saving. A daily archive function classifies and prints the whole day's work in alphabetical order. A protocol of communication allows a connection to a mainframe computer Bayer-Technicon. This program and the user's manual are free of charge, available on request from J. P. Cambus.

Blood Cell Count↗

PubMedDate not supplied

Application of a microcomputer-based system in the analysis of infection data at the emergency units of a large hospital.

After three years of retrospective study in four emergency units from a large hospital (2000 beds) and analysis of 6283 positive cultures, a microcomputer database system was built to store information concerning nosocomial infections in order to help the clinical staff from those units to study the incidence of 20 bacterial species and their sensitivity pattern evolutions for 27 antibiotics (from samples in 15 different collecting sites). This system was developed as an alternative to the hospital mainframe computer microbiological reports. It put emphasis on graphical outputs instead of the coded tables generated by the bigger system. This orientation and the possibility of sectorial infection data analysis were responsible for the general acceptance of the microcomputer-based system by the clinical staff. As the first practical results, the system was able to detect a particular increase in the incidence of Staphylococcus aureus in surgical emergency units (up to 21.6% in 1982) as well as the dissemination of the antimicrobial resistance patterns of S. aureus and Klebsiella pneumoniae from the surgical units to the clinical ones. The time evolution behaviour of Pseudomonas aeruginosa, Escherichia coli and other nonfermentative Gram negative bacilli was also studied to complete the analysis of the most pathogenic bacterial species found in our emergency units.

Brazil↗

PubMed1994

Workstation network system which enables international exchange of characters and images at the University of Tokyo Hospital.

The circumstances when physicians want to exchange information are analyzed and the necessary requirements for workstations are discussed. Although there are many requirements, it will not be necessary to incorporate every requirement onto a single workstation. In the international setting, the capability of handling non-alphabetic characters is also important. The requirements for image display should be classified for those physicians who make their diagnosis primarily on the basis of images and those who use images as additional diagnostic information. On the basis of these discussions, the system of the University of Tokyo Hospital, which is now being implemented, is described. The system will be a network of approximately 300 workstations with one mainframe computer.

Computer Communication Networks↗

PubMed1986

A computerized approach to the collection and analysis of cardiac action potentials.

A description is given of a microcomputer system for the collection and storage of cardiac action potentials. The equipment required is commercially available and easy to use. Analysis of the data is performed off-line with a mainframe computer. A description of the software used for both data collection and data analysis is given.

Action Potentials↗

PubMed1989

A microcomputer-based clinical trial database incorporated with an 'audit trail' for correction process.

Multicenter clinical trials usually involve several hundred research variables with tens of thousands of records and require mainframe computers for processing. Because of recent advances in hardware and software, it has become possible to support data management and statistical analysis for a complex research project totally on a microcomputer. The Veterans Administration Cooperative Studies Program Coordinating Center (CSPCC) in Hines, IL, U.S.A. has successfully implemented three studies employing the SIR/PC Database Management System (DBMS) on an IBM PC AT. The CSPCC DBMS was designed with a method of verifying data and of updating the database, that leaves a more detailed 'audit trial' of the original data and subsequent modifications than provided by the SIR audit trail facility. Data validation can be done at any time throughout the study to facilitate error identification as early as possible in the data handling process. DBMS operation and maintenance are automated by a system of menus. The utility programs are prestored in a procedure file to optimize performance. The simple design speeds implementation and also reduces the cost of development.

Clinical Trials as Topic↗

PubMed1988

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.

An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described. The method is based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores, obtained using a fast pairwise alignment algorithm. Then the multiple alignment is achieved from a series of pairwise alignments of clusters of sequences, following the order of branching in the tree. The method is sufficiently fast and economical with memory to be easily implemented on a microcomputer, and yet the results obtained are comparable to those from packages requiring mainframe computer facilities.

Algorithms↗

PubMed1984

RECFIT: a microcomputer-based nonlinear regression curve-fitting package for the quantitative resolution of beta-adrenoceptor subtypes and estimation of nonspecific binding.

A dedicated nonlinear regression based curve-fitting packages has been developed for quantitative analysis of beta-adrenoceptor subtypes. A feature of this package is the provision to obtain initial parameter estimates using a conversational graphical technique where the user is prompted for parameter estimates, and the resulting curve is displayed over the data. Data are then fitted to a one- or two-binding site model with user-selected weighting and constraints on the parameters. A novel feature is the provision to estimate the nonspecific binding component in the assays as a parameter in the model. The printout for each model consists of the parameters and their standard deviations, estimates of the goodness of fit, an analysis of residuals, and a graph of the data points overlayed with the fitted curve. The nonlinear regression algorithm is based on that of Gauss-Newton. When unweighted, the values determined by RECFIT are essentially the same as those found using the BMDPAR programs on an ICL 2976 mainframe computer. The implementation is reasonably efficient; a typical run for a two-site fit, using nine data points and estimating nonspecific binding, took a total time of about 8 min, excluding data entry and derivation of initial estimates, 4 min for the fitting, 30 sec for graph generation, and 2-3 min for printing of the graph and data.

Binding Sites↗

PubMed1989

Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985.

Between Jan. 1, 1984, and May 1, 1985, 1199 patients with suspected allergic contact dermatitis were patch tested with 32 "standard" allergens, 707 patients with 19 "vehicle and preservative" allergens, and 613 patients with 10 "special study" allergens. Ten dermatologists representing nine geographic centers collected and analyzed data with the use of the American Academy of Dermatology's mainframe computer in Evanston, Illinois. The most common sensitizers identified were nickel, p-phenylenediamine, quaternium-15, neomycin, thimerosal, formaldehyde, cinnamic aldehyde, ethylenediamine, potassium dichromate, and thiuram mix. Each positive reaction was assessed for its clinical relevance.

Adult↗

PubMed1992

Injury surveillance: a method for recording E codes for injured emergency department patients.

STUDY PURPOSE: Little information exists on the cause of injury for patients who are treated and discharged from emergency departments; these patients comprise approximately 90% of all injured patients requiring medical care. A method is described to assign external cause of injury codes (E codes) prospectively to all injured patients seen in a large-volume ED. METHODS: E code assignment was performed by the ED triage nurses on entrance to the ED. A checklist was used that contained frequently occurring codes as identified in a pilot study. E codes were entered into the patients' records on the hospital mainframe computer by a medical records technician. These were acquired for a nine-month period to determine feasibility, accuracy, and ease of use. Accuracy was verified retrospectively. RESULTS: During the nine-month period, 67,495 patients were treated. Acute injury accounted for 16,186 of the visits, and 2,085 were return visits for a previously treated injury. The majority of patients with any injury type were treated and discharged and would not have been included in traditional data sets of injured patients. Overall admission rate for injury was 13%. Accuracy of prospectively assigned E codes was 98%, and this method of assigning E codes resulted in no additional effort by the triage nurse. CONCLUSION: E coding is a valuable method for injury surveillance, easily performed in EDs with high volume. Its value is essential for injury prevention research on injuries from any cause.

Acute Disease↗

PubMed1986

Implementation of a statewide perinatal automated medical network (PAM/NET) for Michigan.

PAM/NET is a computerized data base and conferencing system used by nine neonatal intensive care units in Michigan and Illinois. The system depends on the timesharing resource of a large university mainframe computer. The data base functions are managed by a sophisticated inverted file relational data base management system capable of mass storage and rapid and specific retrieval of individual cases or summary data. Data stored in the system are used to generate admission, discharge and developmental assessment clinic summaries that serve as such for the medical record and as letters to primary physicians. We report here the early experience in the design and dissemination of this database network to the participating hospitals. Conflicting goals of sharing and confidentiality of clinical data are addressed in the design of this system.

Ambulatory Care Facilities↗

PubMed1985

From micro to mainframe. A practical approach to perinatal data processing.

A new, practical approach to perinatal data processing for a large obstetric population is described. This was done with a microcomputer for data entry and a mainframe computer for data reduction. The Screen Oriented Data Access (SODA) program was used to generate the data entry form and to input data into the Apple II Plus computer. Data were stored on diskettes and transmitted through a modern and telephone line to the IBM 370/168 computer. The Statistical Analysis System (SAS) program was used for statistical analyses and report generations. This approach was found to be most practical, flexible, and economical.

Computers↗

PubMed1999

A generalized rank-order method for nonparametric analysis of data from exercise science: a tutorial.

Frequent violations of the assumption that data are normally distributed occur in exercise science and other life and behavioral sciences. When this assumption is violated, parametric statistical analyses may be inappropriate for data analysis. We provide a rationale for using a generalized form of nonparametric analyses based on the Puri and Sen (1985) L treated as a chi 2 approximation. If data do not meet the assumption of normality, this nonparametric approach has substantial power and is easy to use. An advantage of this generalized technique is that ranked data may be used in standard parametric statistical programs widely available on desktop and mainframe computers, for example, regression, analysis of variance (ANOVA), multivariate analysis of variance (MANOVA) within BioMed, SAS, SPSS. Once the data are ranked and analyzed with these programs, the only adjustment required is to use a standard formula to calculate the nonparametric test statistic, L, instead of the parametric test statistic (e.g., F). Thus, rank-order nonparametric models become parallel with their parametric counterparts allowing the researcher to select between them based on characteristics of the data distribution. Examples of this approach are provided using data from exercise science for regression, ANOVA (including repeated measures) and MANOVA techniques from SPSSPC. Using these procedures, researchers can easily examine data distributions and make an appropriate decision about parametric or nonparametric analyses while continuing to use their regular statistical packages.

Analysis of Variance↗

PubMed1996

RNAdraw: an integrated program for RNA secondary structure calculation and analysis under 32-bit Microsoft Windows.

The use of algorithms for calculation and analysis of RNA secondary structures has largely been limited to mainframe computers, mainly due to the 16-bit memory restrictions imposed by MS-DOS. The program presented here, RNAdraw, moves calculations to the 32-bit Microsoft Windows environments with an intuitive user interface with extensive viewing, editing and printing possibilities. The algorithms for secondary structure/basepair probability matrix/heat curve calculation have been ported directly from a 32-bit Unix environment. RNAdraw also offers novel features such as the options to edit energy parameters, extract structures of different probability levels, create de novo secondary structures interactively, and combine viewing of structures and basepair probabilities.

Algorithms↗