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At least 109 records · Page 6Linked to original sources
PubMed1997

Recombinant human interferon-beta for condylomata acuminata: a randomized, double-blind, placebo-controlled study of intralesional therapy.

To assess the efficacy of a novel glycosylated mammalian cell derived recombinant human interferon-beta (r-hIFN-beta-1a) in the intralesional treatment of genital condylomata acuminata. The study was randomized, double-blind and placebo-controlled. Patients (n=60) with up to 8 distinct condylomata acuminata were randomized to receive either one million international units (IU) of r-hIFN-beta-1a or placebo intralesionally into each lesion, 3 times a week, for a total of 9 occasions. Biopsies were taken from each patient before enrolment to allow human papillomavirus (HPV) testing, and patients were tested for the development of anti-IFN-beta antibodies. Efficacy was assessed by measuring the complete response rate 3 months after treatment. The complete response rate was not significantly better with r-hIFN-beta-1a than with placebo. However, after 3 months, 73.3% of patients treated with r-hIFN-beta-1a had experienced at least a partial response to treatment, compared with 33.3% of placebo-treated patients. At 19 days and 6 weeks, r-hIFN-beta-1a produced a significantly larger reduction in the area of condylomata. Lesions with detectable HPV6 or 11 showed a trend towards a better response rate to treatment with r-hIFN-beta-1a than lesions where no HPV DNA was detected. The treatment was well tolerated. In the 5 patients who developed non-neutralizing anti-IFN-beta antibodies, therapeutic efficacy was not compromised. Intralesional r-hIFN-beta-1a was effective in the reduction of the size of genital condylomata acuminata.

Adolescent↗
PubMed1999

[Condylomata acuminata: a rare symptom of ubiquitous human papilloma virus and not a sign of risky sex behavior].

In general, condylomata acuminata can be diagnosed and treated by the general practitioner. Condylomata are caused by certain types of human papillomavirus (HPV). According to their carcinogenicity HPVs are classified as high risk and low risk HPV. The benign condylomata are an infrequent sign of an infection with low risk HPV, while cervical cancer is a rare and late complication of an infection with high risk HPV. Because high and low risk HPV are different viruses, the risk of cervical cancer is not increased by condylomata. Anogenital HPVs are predominantly transmitted sexually. It is useful to discriminate between sexually transmitted diseases (STDs) that are ubiquitous, like infections with HPV or herpes simplex virus (HSV), and rare STDs like syphilis, gonorrhoea and HIV infection: infections with HPV and HSV are also common with unriskful sexual behaviour, while syphilis, gonorrhoea and HIV infection are almost exclusively associated with riskful sexual behaviour. It has been shown that double infections with HPV and Chlamydia trachomatis are not more frequent than may be expected by chance. The literature indicates that the presence of condylomata acuminata by itself is no reason to screen patients for other STDs.

Condylomata Acuminata↗
PubMed1982

Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA.

32P-labelled cloned HPV 6 DNA was used as probe to analyze human genital tumors for DNA sequences homologous to HPV 6 DNA. Ninety three percent of all condylomata acuminata (41 out of 44) were found to harbor HPV 6 DNA. Of the remaining three, one contained HPV 1 DNA. No papillomavirus DNA was identified in the two other tumors. All three invasively growing giant condylomata acuminata (Buschke-Löwenstein tumors) investigated also contained HPV 6 DNA. Two out of six atypical condylomata of the cervix hybridized with HPV 6 DNA under stringent conditions, one only under conditions of low stringency. All DNA preparations from malignant tumors studies (54 cervical carcinomas, 10 penile carcinomas, two vulvar carcinomas) failed to anneal with HPV 6 DNA, even under conditions of low stringency. Although all HPV 6-positive condylomata acuminata analyzed in this study revealed HPV 6 DNA of regular molecular weight (5.1 x 10(6)), two of the Buschke-Löwenstein tumors, as well as one of the two positive atypical condylomata of the cervix, contained HPV 6 DNA with a remarkable size classes occurred in a supercoiled form without evidence for integration into host cell DNA.

Animals↗
PubMed1999

Increased telomerase activity and decreased telomere length in genital condylomata acuminata.

Our objective was to find a possible correlation between telomerase activity, mean telomere length and human papillomavirus (HPV) presence and type in genital condylomata acuminata. Fifteen biopsies from women with genital condylomata acuminata and nine control tissue samples were tested for telomerase activity, mean telomere length, and HPV presence and type. All condylomata exhibited telomerase activity, compared to 78% of the control samples. The mean telomere length of condylomata was significantly (P<0.002) shorter compared to telomere length in control tissue samples. All condylomata lesions were infected with HPV types 6/11, and more than half had additional infection with HPV 16/18. Mixed HPV 6/11 with 16/18 infection correlated with shorter telomeres than presence of HPV 6/11 alone in the lesions (4.68 +/- 0.44 kb vs 4.97 +/- 0.57 kb). None of the control tissue samples showed presence of HPV DNA. Telomerase activity may be a marker of proliferation rather than malignancy, whereas the mean telomere length could better serve as a marker for the progression of HPV lesions toward malignancy.

Biopsy↗
PubMed1986

[Chlamydia trachomatis infection in a patient with condylomata acuminata].

Chlamydia trachomatis cervical infection was observed in a 19-year-old woman with genital condylomata acuminata. To isolate C.trachomatis, cycloheximide-treated McCoy cells and a culture-independent monoclonal antibody were used. In addition, a single-antigen immunofluorescence test was made to determine the chlamydia antibody titer. Condylomata acuminata are induced by human papillomaviruses (HPV), predominantly types 6 and 11. This case shows that simultaneous genital infection of C.trachomatis and HPV requires special attention.

Adult↗
PubMed1983

[Cryotherapy of condylomata acuminata].

Between 1972 and 1982, 162 women between the ages of 15 and 66 were treated with cryosurgery at the Gynaecological Department of the Medical Academy Erfurt. 43 of these patients were pregnant between the twelfth and the thirty-second gestational week. - Until 24 months after the first cryosurgery we found one to four recurrences of condylomata acuminata in 14 patients which were treated cryosurgically again. Report is given about one case of condylomata acuminata gigantea, treated by cryosurgery, too. Contrary to electroresection and surgical resection after chlorethyl-freezing we think cryosurgery has an advantage in quickly necrosing, sequestering without further surgical measurements and healing without scars. - Therefore we consider cryosurgery as the most efficient method in the treatment of condylomata acuminata, also during pregnancy.

Adolescent↗
PubMed1995

[The conservative treatment of condylomata acuminata with Solcoderm].

The conservative treatment of the condylomata acuminata by Solcoderm is local, painless and ambulatory. One application of Solcoderm by a capillary pipette covering the pathologic formations is enough--they become rapidly devitalized and disappear within 4 weeks. Secondary infections on the treated area are extremely rare.

Acetates↗
PubMed2000

Human papillomaviruses and DNA ploidy in anal condylomata acuminata.

Previous studies have emphasized the usefulness of DNA ploidy measurement and Human Papillomavirus (HPV) detection as prognostic markers in low grade cervical lesions. We addressed the eventual relationship between HPV type, DNA profile, and p53 tumor suppressor protein expression in anal condylomata acuminata to eventually determine parameters which may be considered as predictive risk factors for the development of cancer. DNA ploidy was assessed by image cytometry after Feulgen staining of contiguous serial sections of 45 anal condylomata acuminata without atypia containing HPV detected by in situ hybridization and Polymerase Chain Reaction (PCR). p53 expression was detected by immunohistochemistry. DNA aneuploidy was found in 53.3% of these lesions, 48.9% containing non oncogenic HPV types 6 and/or 11 and 4.4% harbouring HPV types 11 and 18. The DNA diploid lesions were all associated with non oncogenic HPV types 6 and/or 11 and one case also contained HPV type 33. There was no significant correlation between the detection of DNA aneuploidy and the presence of immuno-detected p53. DNA aneuploidy was not related to the presence of oncogenic HPV in anal condylomata acuminata. The DNA aneuploid profile frequently observed, especially in lesions associated with non oncogenic HPV types, is not yet well explained and cannot be considered as a prognostic factor. In contrast, a more intensive clinical follow-up should be proposed in patients with oncogenic HPV associated to DNA aneuploidy.

Adult↗
PubMed1985

Comparison of podophyllin application with simple surgical excision in clearance and recurrence of perianal condylomata acuminata.

60 patients with first-episode perianal condylomata acuminata were randomly assigned to podophyllin application or surgical excision. 58% of the male patients were homosexual and 33% of the female patients regularly had anal intercourse. Podophyllin completely cleared warts from 23 of 30 (76.6%) patients compared with 28 of 30 (93.3%) for surgical excision. After wart clearance the cumulative recurrence rates were 18% for surgical excision and 43% for podophyllin at 3 months (p less than 0.05), 22% and 56% at 6 months (p less than 0.01), 26% and 56% at 9 months (p less than 0.01), and 29% and 65% at 12 months (p less than 0.01). All patients were treated as outpatients and all surgical procedures were carried out under local anaesthesia. Both regimens were well tolerated.

Adolescent↗
PubMed1998

Traditional therapies for the treatment of condylomata acuminata (genital warts).

The evaluation of therapies for condylomata acuminata (genital warts) is imprecise because it is not possible to distinguish between relapse (reappearance of previously treated warts) and reinfection (appearance of new warts in a new location). Published trials use diverse criteria for patient selection, therapeutic response and follow-up period. A further complication is that current treatments aim to clear visible lesions, which is no proof of cure as human papillomavirus may persist in a latent state. Within these limitations, the advantages and disadvantages of current therapies are reviewed, including first-line therapies such as podophyllin solution, podophyllotoxin alcohol solution or cream, cryotherapy with liquid nitrogen, laser therapy (both carbon dioxide and NdYag), and trichloracetic acid. Second-line therapies, such as electrosurgery, excision, 5-fluorouracil and interferons, are also reviewed. In general, all available treatments for genital warts are more or less unsatisfactory, with recurrence rates of 30-70% at 6 months follow-up periods.

Antimetabolites↗
PubMed1990

Condylomata acuminata in the pediatric population.

The incidence of condylomata acuminata infection has shown a steady increase for adults and children in recent years. With the discovery that the viral agents of this disease are potentially neoplastic, a disorder that was once considered a nuisance is now taking on new-found importance and concern. Furthermore, the knowledge that these lesions are often sexually transmitted and the ever-increasing concern over child abuse have combined to make the recognition and treatment of this disease in the pediatric population of even greater significance. Depending on location, podophyllum resin (podophyllin) is the initial therapy of choice. Available studies indicate a cure rate ranging from 22% to 98% depending on location of the warts, frequency of treatment, patient compliance, and freshness of the podophyllum resin preparation. Cure rates of 91% to 97% have been reported with cryotherapy and laser photocoagulation. Eradication of the viral agent and long-term follow-up are important.

Adolescent↗
PubMed1985

The CO2 laser for recurrent and therapy-resistant condylomata acuminata.

The medical records of 48 patients who underwent laser vaporization of therapy-resistant or recurrent condylomata acuminata were studied with regard to history of immunosuppression, location of original lesion, type and duration of therapy, and whether magnification devices were used prior to or during therapy. The genitalia of the patients' sexual partners were examined in all cases in which the condylomata recurred after initial control of the lesions with conventional methods. In 46 of the 48 cases, possible reasons for the failure of conventional therapy could be found: unresponsive to chemical therapy (11 patients); reinfection by the sexual partner (4); immunosuppression (8); several factors (6); and incomplete eradication of the lesion (20). Thirty-eight of the 48 patients (79%) were treated successfully with one-time laser ablation of the lesions. Six patients with recurrent condylomata after laser therapy underwent a second laser treatment, and four of the six patients (total, 87%) have remained free of disease. The laser appears to be an effective method of treatment for recurrent or persistent condylomata acuminata provided that (1) the patient is not immunosuppressed, (2) the potentially infected sexual partner is examined and treated, if necessary, and (3) the external genitalia, including the anus, vagina and cervix, are carefully examined colposcopically to rule out the persistence of small lesions.

Adolescent↗
PubMed1989

[Interferon in the treatment of condylomata acuminata].

In the present study we used the well known antiviral properties of interferon alpha 2b in condylomata acuminata. Firstly we investigated 3 different application forms. We found that 1. the local INF application in gel was completely ineffective, 2. the injection of INF into the base of the warts was effective but too painful for routine therapy, 3. the systemic treatment by s.c.-injection had an excellent compliance and a high efficacy. In the second part of the study we treated 16 patients with our own s.c.-regimen of 3 x 5 mill. U and 6 x 2 mill. U INF alpha 2b within 5 weeks. 60% showed a complete response, 30% a partial response; these were treated surgical afterwards. In none of the patients a relapse occurred at a median follow-up of 11 months. The observed side-effects were poor. We consider the systemic treatment with interferon for condylomata acuminata to be highly effective and well tolerated. The relapse rate is very poor.

Administration, Topical↗
PubMedDate not supplied

Human papillomavirus detection in cervical dysplasias or neoplasias and in condylomata acuminata by in situ hybridization with biotinylated DNA probes.

Specimens from cervical dysplasias or carcinomas and genital condylomata acuminata were retrospectively analysed by in situ hybridization (ISH) with biotinylated DNA probes for human papillomavirus (HPV) types 6, 11, 16 and 18. In the control group no case was positive for HPV DNA. In mild/moderate dysplasias, 4 cases (14%) were positive for HPV 6 or 11 and 2 cases (7%), for HPV 16. In the severe dysplasia/in situ carcinoma group, 9 cases (31%) showed presence of DNA of HPV types 16 or 18. Six invasive carcinomas (20%) were positive for HPV type 16 or 18. Among condylomata acuminata, 22 cases (73%) were positive for HPV types 6 or 11. In all ISH-positive cases only one viral type was detected. No correlation between HPV DNA positivity and histological findings of HPV infection was observed. Although less sensitive than some other molecular biology techniques, in situ hybridization with biotinylated DNA probes proved to be simple and useful for detecting and typing HPV in samples routinely received for histopathological analysis.

Biotin↗
PubMed2004

Condylomata acuminata of the neovagina in a HIV-seropositive male-to-female transsexual.

We present an unusual case of condylomata acuminata arising in the transplanted skin of a neovagina in a male-to-female transsexual. The neovagina had been constructed using a penile and a scrotal skin flap. Resection of the larger condylomata was performed; then all visible lesions were ablated by electrovaporization. Microsocpic examination and DNA hybridization revealed condylomata acuminata due to human papillomavirus type 16, 31, and 33 infection.

Adult↗
PubMed1984

[Multiple papilloma virus particles in perianal condylomata acuminata of a drug-dependent patient].

A 24-year-old male drug-dependent patient with perianal exophytic condylomata acuminata is reported. An increased production of papillomaviruses could be demonstrated by means of electron microscopy and immunocytochemistry (peroxidase-antiperoxidase technique). This is in contrast to earlier investigations of exophytic condylomata acuminata, which revealed characteristically small amounts of mature papillomavirus particles. The basis for the different form of papillomavirus infection of the anogenital region in this drug-dependent patient is discussed.

Adult↗