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At least 109 records · Page 6Linked to original sources

PubMed2003

Porcine enamel matrix derivative enhances the formation of reparative dentine and dentine bridges during wound healing of amputated rat molars.

We examined the biological effects of porcine enamel matrix derivative (EMD; Emdogain) on the formation of reparative dentine and dentine bridges in rat molars after pulp amputation. The pulp chambers of upper molars of Wistar rats were perforated and the amputated pulp surfaces were directly capped with either EMD or its carrier propylene glycol alginate (PGA) as control. The cavities were then restored with glass-ionomer cement. On post-amputation days 4-30, the dissected maxillae were examined by light and electron microscopy. In PGA-capped pulp, reparative dentine had been formed over the dentine walls under the prepared cavity on day 7 post-amputation and its thickness extended until day 30. On day 30, as well as reparative dentine formation, diffuse calcification had occurred beneath the amputated wound surfaces. Dentine bridge formation under the amputated coronal pulp surface was observed in 18.2% of amputated pulp on day 30. In EMD-capped pulp, reparative dentine had already been formed by odontoblast-like cells over the dentine walls, already on day 4 post-amputation, and its thickness extended until day 30. The Ca and P weight % and Ca/P ratio of reparative dentine matrix were similar to those of pre-existing dentine matrix, and these values were not different between PGA and EMD-capped pulp. Dentine bridge formation was observed in 27.3% of EMD-capped pulp on day 30. Our results suggest that EMD enhances the formation of both reparative dentine and dentine bridges during wound healing of amputated rat molar pulp.

Amputation, Surgical↗

PubMed2006

Reaction of rat pulp tissue to Carisolv 'new gel'--a histocytological evaluation.

BACKGROUND: This study was an histological examination of pulp tissue exposed to Carisolv 'new gel' after 1 to 28 days. METHODS: An occlusal cavity was prepared in 64 caries-free molar teeth of 16 Wistar rats. The roofs of the pulp chambers were perforated and Carisolv 'new gel' solution was placed onto the exposed pulps of 32 molar teeth for 20 minutes. Thirty-two contralateral molar teeth served as controls and were coated with an inert liquid containing isotonic saline solution and carmellose for 20 minutes as well. The pulps of all teeth were capped with Ca(OH)2 and the cavities were filled with a flowable composite in combination with a self-etching dentine adhesive. The animals were sacrificed after 1, 3, 7 and 28 days. Eight teeth per group and the time period were histologically examined, scored, and statistically evaluated (Wilcoxon-test). RESULTS: The results showed no statistically significant differences between the Carisolv group and the control group (p > 0.05). The observed pulp reaction was essentially the same as those reported in the past being typical for the effect of calcium hydroxide as a direct pulp capping agent. CONCLUSION: Compared to Ca(OH)2, Carisolv 'new gel' did not cause any different or additional pulp reaction in healthy teeth.

Animals↗

PubMed1977

[Decisive factors in the indication for pulp and peridontal treatment].

The explanation of the goal of pulp-periodontium treatment is followed by guidelines concerning the indication for the methods of pulp preservation (indirect capping, direct capping, pulpitis treatment by means of anaesthetics), of partial pulp preservation (vital amputation) and for pulpectomy (vital and non-vital techniques). The different passages of the paper terminate with conclusions for practice.

Administration, Topical↗

PubMed2004

[Uses of MTA, a review. Part 2: Clinical applications].

Mineral trioxide aggregate (MTA) has been used in dentistry for the last five to eight years. Because of its high biocompatibility, its good sealing ability, and the fact that cemental tissues grow on this material, it has a relatively wide range of applications in endodontics. MTA may be used to cap exposed vital pulps, to seal open apices or perforations, or as a retro-filling material in apical surgery. These applications are presented in the current article, and discussed based on case reports.

Aluminum Compounds↗

PubMed1979

[Long-term clinical supervision of direct pulp capping (performed by the students of the School of Dentistry, Geneva)].

Of 123 teeth treated by direct pulp capping 110 could be rechecked clinically and radiographically after periods of 1 1/2 to 7 years, 4 on the average. In 25 cases a change in endodontic treatment has been recorded on the files: In 18 cases biopulpectomy was performed for symptomatic (pain) reasons considered as failure of the capping treatment; in 5 cases biopulpectomy was indicated for periodontal and prosthetic reasons (not considered as failure); in 5 cases of the 110 rechecked necrosis and periapical involvement was diagnosed. The rate of failure thus was 22 cases or 17%. This relatively high ratio of unfavorable results (Tab. VII) is in part due to lack of operative skill of the students while progressing tooth morbidity statistically established in the Genevan population also was taken into account. Advancing tooth ages according to graph figure 6 in accordance with other recent surveys were found to constitute no impediment for direct pulp capping. The success of this endodontic treatment is best ascertained by observing a strict selection of the case and the observance of an exacting operative procedure, namely: - Only accidentally exposed pulps without symptoms of previous spontaneous pain (Category I) are liable to successful conservation by direct pulp capping using calcium hydroxide. Previously painful pulps (Category II) according to Table VIII are either indirectly capped using corticosteroids particularly in young teeth or after exposure subject to coronal or radicular pulpotomy (Category III). Rigorous aseptical procedure and lasting hermetical sealing of the calcium hydroxide pulp dressing are additional prerequisites for success.

Adolescent↗

PubMed1991

Healing of pulp exposures: an ultrastructural study.

The fine structure of tissue changes during the first 14 days following pulp exposure and capping with a hard setting Ca(OH)2 cement has been studied. The early changes included hemorrhage and moderate inflammation which were largely resolved during the first week. During the second week differentiation of cells occurred at the wound surface. These cells had the characteristic features of odontoblasts and formed a predentin-like collagen matrix. The capping material was closely adapted to cellular structures at the wound surface or to the predentin-like matrix at all observation periods. Dentin fragments displaced into the pulp tissue during cavity preparation, acted as sites for pulp stone formation.

Animals↗

PubMed2001

Response of human pulps capped with a self-etching adhesive system.

OBJECTIVE: The aim of this study was to evaluate the human pulp response following direct pulp capping with a current self-etching bonding agent and calcium hydroxide (CH). METHODS: Thirty-three sound human premolars had their pulp tissue mechanically exposed. Sterile distilled water was used to control the hemorrhage and exudation from the pulp exposure site. The pulps were capped with Clearfil Liner Bond 2 (CLB-2) or CH and the cavities were filled with a resin composite (Z-100) according to the manufacturer's instructions. After 5, 30 and 120-300 days, the teeth were extracted and processed for microscopic examination. RESULTS: At short-term, CLB-2 elicited a mild to moderate inflammatory pulp response with dilated and congested blood vessels adjacent to pulp exposure site. With time, macrophages and giant cells engulfing globules and particulates of resinous material displaced into the pulp space were observed. This chronic inflammatory pulp response triggered by fragments of bonding agent displaced into the pulp space did not allow pulp repair interfering with the dentin bridging. On the other hand, pulps capped with CH exhibited an initial organization of elongated pulp cells underneath the coagulation necrosis. Pulp repair and complete dentin bridge formation was observed at long-term evaluation. SIGNIFICANCE: The present study demonstrated that CH remains the pulp capping agent of choice for mechanically exposed human pulps. CLB-2 did not allow complete connective tissue repair adjacent to the pulp exposure site. Consequently, this bonding agent cannot be recommended for pulp therapy of sound human teeth.

Acid Etching, Dental↗

PubMed1979

Endodontic treatment of primary teeth.

Endodontic treatment of primary teeth is undertaken by indirect pulp capping, direct pulp capping, formocresol pulpotomy and pulpectomy. The same treatment principles apply to both primary and permanent teeth with infected or necrotic pulps. The main differences are the use of formocresol for root canal medication and a resorbably zinc-oxide and eugenol paste for root canal obturation.

Child↗

PubMed2000

Reversible and irreversible painful pulpitides: diagnosis and treatment.

The foregoing clinical evidence indicates that when pain is severe, or when mild to moderate pain is present with a previous history of pain in the aching tooth, with or without periapical radiolucency, the tooth is in the IRPP category. Treatment dictates endodontic therapy or extraction. On the other hand, when clinical evidence indicates that the pain is mild or moderate with no previous history of pain, normal pulp vitality, and there is no positive percussion sign, the pulp is in the RPP category. Treatment dictates indirect or direct pulp capping in teeth with or without periapical radiolucency. The success rate favours teeth with no periapical radiolucency, 98%; in teeth with periapical radiolucency the success rate is less favorable, 43%. Efforts should be made to maintain pulp vitality. Endodontic therapy can always be done, if in time the pulp develops necrosis.

Adolescent↗

PubMed1980

[Pulp reaction and formation of hard substances after direct capping with a lyophilized collagen preparation].

The course of healing following direct capping of the pulp with collagen fleece differed from that after capping with Calxyl. The collagen fleece covering the pulp and filling part of the dentinal defect was replaced by newly formed pulp tissue with a new growth of dentine from the margins. Calxyl however initially produced localized necrosis. Hard substance was deposited in this circumscribed necrotic area.

Calcium Hydroxide↗

PubMed1996

A clinical study of direct pulp capping applied to carious-exposed pulps.

Direct pulp capping of carious-exposed pulp was performed on 44 teeth. We evaluated the success rates of these cases, and analyzed the relationships between the success rates and their clinical findings. Furthermore, we examined the length of time necessary for adequate postoperative follow-up. The success rate in this study was 81.8%. Age of the patients, type of teeth, responses to thermal stimuli and percussion, and the diameter of pulpal exposure had no bearing on the success rate. However, the degree of bleeding on pulpal exposure was related to the success rate (p = 0.042). The success rates of cases in which postoperative follow-up periods were 3 to 18 months were similar (80 to 83%), whereas those with follow-up for 21 months (91.7%) and 24 months (100%) showed higher success rates. These results showed that direct pulp capping was applicable to carious-exposed pulp, and the degree of bleeding is indicative of the prognosis of this treatment. The length of time necessary for adequate postoperative follow-up was suggested to be 21 months.

Adult↗

PubMedDate not supplied

The pulp capping procedure in primary teeth "revisited".

The purpose of this review is to "revisit" an earlier paper (1992) on the subject of direct pulp capping in primary teeth and bring some new considerations for the procedure by the use of dentin bonding adhesives. It has come to be recognized that the customary employment of calcium hydroxide for this therapy has some shortcomings that reduce the prognosis for a favorable outcome. For at least a decade, many investigations have found that postoperative sensitivity, thermal stimuli, pulp inflammation and pathosis can be attributed not to the composition of various dental materials and their insertion techniques, but to microleakage with subsequent bacterial invasion at the enamel/restoration and the dentin/pulp interfaces. It is imperative, as pointed out, that there be an impervious resinous bond between the dentin and the dentinopulpal complex which can be achieved by the use of dentinal adhesive agents to eliminate microleakage outward movement of pulpal fluids. Various steps in the bonding technique for the treatment of deep dentin caries and/or a pulp exposure has raised some concerns for their effect on the pulp. This review discusses these concerns, which can lead to the conclusion that the use of dentinal bonding adhesives is a safe and biologically feasible procedure, whether it be in permanent or primary teeth.

Adhesives↗

PubMed2001

One-visit apexification: technique for inducing root-end barrier formation in apical closures.

Numerous procedures and materials have been utilized to induce root-end barrier formation. Mineral trioxide aggregate (MTA) was introduced to dentistry as a root-end filling material. It has been advocated for filling root canals, repairing perforations, pulp capping, and root-end induction. Mineral trioxide aggregate reacts with tissue fluids to form a hard tissue apical barrier. As a result, MTA shows promise as a valuable material for use in one-visit apexification treatment, primarily for treating immature teeth with necrotic pulps.

Aluminum Compounds↗

PubMed1998

Pulpal response to a resin-modified glass-ionomer material on nonexposed and exposed monkey pulps.

OBJECTIVE: This study evaluated the biocompatibility of a resin-modified glass-ionomer material on monkey pulps. METHOD AND MATERIALS: Standardized Class V cavities were prepared in 112 teeth distributed in six healthy adult monkeys. The resin-modified glass-ionomer cement was placed in 24 nonexposed and 36 exposed pulps according to manufacturer's instructions. ZOE was used as a control in nonexposed pulps, while calcium hydroxide was used as a control for exposed pulps. Tissues were collected at 6 to 7, 21 to 27, and 90 to 97 days. After demineralization, the teeth were serially sectioned, stained, and observed by light microscopy. RESULTS: Except for one resin-modified glass-ionomer pulp at 6 days, there were no differences between the responses of nonexposed pulps to resin-modified glass-ionomer specimens and ZOE controls. In exposed pulps, eight of 36 resin-modified glass-ionomer pulps showed various grades of inflammatory response, all associated with stained bacteria. Pulpal healing was similar in both resin-modified glass-ionomer and calcium hydroxide direct-capped exposures. Twenty-two of 26 exposed pulps restored with the resin-modified glass-ionomer cement showed dentin bridge formation at 21 and 97 days. CONCLUSION: The resin-modified glass-ionomer material exhibited acceptable biologic compatibility in exposed and nonexposed cavities.

Analysis of Variance↗

PubMed1983

Bacterial contamination and the "toxicity" of materials to the exposed pulp.

The role of bacterial contamination in the toxicity to the pulp of a number of metallic salts was investigated. These had been tested as pulp-capping agents in previous studies involving 228 exposed rat molars. Material from the previous investigations was stained to demonstrate bacteria. This revealed bacteria in necrotic pulp tissue and/or the cavity-restoration interface in approximately 60% of the specimens. The presence of bacteria appeared to be related to pulpal inflammation, necrosis, and failure of calcific repair.

Animals↗

PubMed1990

[Direct capping of the artificial exposed pulp in teeth with deep caries].

We carried out clinical and histological investigations on teeth with superficial and deep caries in which we made an artificial exposure of the pulp to check the reactivity of the endodont. After one year we observed using clinical and x-ray methods successful treatment in 93.4% of the teeth. Histologically the number of successful treatment was 100.0% in teeth with superficial caries and 80.0% in teeth with deep caries.

Adolescent↗

PubMed1997

Intravital treatment of the pulp with simultaneous laser biostimulation.

The aim of the study was clinical and radiological evaluation of the pulp treatment using direct capping and amputation under anaesthesia with simultaneous laser biostimulation. Thirty procedures were performed using laser and thirty-six without it. In all cases non-setting Ca(OH)2 was applied as a biological dressing. The results obtained provide justification for the application of laser biostimulation to biological treatment of the pulp.

Adult↗

PubMed1985

Pulp response after calcitonin treatment of direct exposures in the dog.

The hypocalcemic hormone, calcitonin, was used in directly pulp-capped teeth to determine whether or not calcitonin promoted healing. Two dogs were used. Twelve teeth received the calcitonin; nine control teeth were prepared, and five were treated with calcium hydroxide. Calcitonin did not increase either the rate of healing or the amount of secondary dentin formed. Calcitonin reduced the degree of inflammation in the treated tooth pulps.

Animals↗