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94 records · Page 6Linked to original sources

PubMed1978

[Emerson-Trinder reaction: study of various chromogens and analyses of the principle interferences (author's transl)].

Several phenolic compounds and aromatic amines were tested with a system consisting of hydrogen peroxide, peroxidase and 4-aminophenazone for their chromogenic activity in the Emerson-Trinder reaction: sulphonated 2,4-diclorophenol had the greatest activity, about 4 times that of unsubstituted phenol. The mechanism of action of serum components (serum proteins, bilirubin and ascorbic acid) which can interfere in the Emerson-Trinder reaction was also investigated by the same analytical system. Binding of phenolic compounds to serum was found to be responsible for protein interference: this can be overcome by increasing the phenolic compounds concentration. The interference by bilirubin and ascorbic acid is due to hydrogen peroxide consumption, in competition with the chromogenic substrate.

Aminopyrine↗

PubMed1993

[Study of combinations of antimicrobial agents. Development of the method].

We developed and validated a micromethod similar to the checkerboard method in antibiotherapy to study the efficiency of antiseptic and disinfectant molecules. The determination of the FBC index (Fractional Bactericidal Concentration) on 4 reference strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae) for 4 associations (2-benzyl-4 chlorophenol--iodophor; cetrimide-iodophor, 2 benzyl-4 chlorophenol--formaldehyde; hexamidine--formaldehyde) revealed 2 synergistic associations and 2 antagonistic associations for one or more strains.

Anti-Bacterial Agents↗

PubMed1976

[A microbiological investigation of the effectiveness of Micro Megas E-spray].

The disinfecting effect of Micro Megas E-spray was tested using a microbiological technique which also included a practical test. Contra-angels and straight handpieces which were sprayed after being used for treatment on patients, and then dried and incubated in a liquid medium, showed a marked growth of microorganisms. The spray had a weak and barely significant growth inhibiting effect on contaminated, simulated instrument surfaces. using Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus as test bacteria. It is concluded that the spray is not suitable for distinfection of contra-angels and straight handpieces.

1-Propanol↗

PubMed1976

[Synthetic antimycotica (author's transl)].

In addition to the antimycotic antibiotics described in a previous paper (Tijdschr. Diergeneesk., 101, 900-904, (1976)), the drugs used in the treatment of dermatomycosis include a fairly large number of synthtic compounds showing a wide variety of chemical structures. These are partly old and occasionally even obsolete agents (often in use as early as prior to 1945); a number of these drugs are of more recent date. They will be discussed in the present paper. So far as is known, the physicochemical and pharmacotoxicological properties, antifungal range, mechanisms of action and preparations will be reviewed.

Antifungal Agents↗