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At least 109 records · Page 6Linked to original sources
PubMed1983

Antagonistic effects of aldosterone on corticosterone-mediated changes in exploratory behavior of adrenalectomized rats.

The effect of aldosterone administration on exploratory activity of chronic adrenalectomized (10 days) male rats was investigated. Aldosterone (30 micrograms/100 g body wt sc) administered 1 hr or 30 min prior to the behavioral test failed to normalize disturbed exploratory activity of adrenalectomized rats, in contrast to the restoration observed after corticosterone, the naturally occurring glucocorticoid of the rat. Administration of the mineralocorticoid 30 min prior to corticosterone prevented the normalization of the behavioral response by the latter steroid. Administration of the same dose of aldosterone 30 min prior to a tracer amount of [3H]corticosterone effectively blocked cell nuclear uptake of radioactive-labeled hormone in the hippocampus. The specific action of corticosterone on exploratory behavior corresponds with the stringent specificity of the neuronal hippocampal corticosterone receptor system. Mineralocorticoid receptors do not seem to be involved in effects on this behavior. The antagonistic action of aldosterone is probably exerted by competitive binding to the corticosterone receptor.

Adrenalectomy↗
PubMed1989

Exploratory behavior, reaction to novelty, and proactive memory in rats with temporo-entorhinal connections disrupted.

The parahippocampal cortex is ascribed a key function in mediating reciprocal connections between neocortical association areas and the hippocampal formation. Within this complex the lateral entorhinal cortex (LEC) seems to stand out as an important interface exerting modulating influence upon cognition and memory by way of its connections with the hippocampal formation and temporal cortex (TC), respectively. The purpose of the present study was to compare effects of TC/LEC disruptions in a novelty test with results previously obtained in the same test following lateral perforant path (LPP) disruptions. Further, effects of TC/LEC lesions on proactive memory were examined, since a profound impairment in retroactive memory has previously been found. Rats bearing TC/LEC lesions or LPP lesions behaved differently in the novelty test. It was also shown that the impairment in proactive memory was less severe than the one seen in retroactive memory following TC/LEC lesions. The results are discussed in terms of a highly integrative role of LEC.

Animals↗
PubMed1978

Exploratory behavior in rats following bilateral lesions of the anterodorsal caudate nuclei.

9 rats received bilateral lesions to the anterodorsal caudate nuclei and 9 rats underwent sham operation procedures. After recovery the subjects were observed in an apparatus allowing access to familiar or novel stimuli. The caudotomized rats spent a significantly greater proportion of time exploring the novel stimuli. The results were not consistent with the suggestions that following damage to the caudate nucleus animals were unresponsive to novelty, however, they did support earlier findings implicating the caudate nucleus in learning and memory processes.

Animals↗
PubMed1989

Exploratory behavior and the dual activity of some psychoactive drugs. Part 5. Alcohol.

Alcohol is reported to impair acquisition and learning processes and it is considered a depressant of the brain activities impairing rapidity and consistency of some behaviors. The experiments reported here are concerned with the exploratory performances of the already described subpopulations of Albino mice under the effect of alcohols of different types.

Alcoholic Beverages↗