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1-second forced expiratory volume and density dependence in early airflow limitation.

Density dependence variables (helium-to-air difference in forced expiratory flows at 50 and 25% vital capacity and volume of isoflow) were compared with spirographic performance (vital capacity, FEV 1.0) in 76 men aged 33-56 years. The group included nonsmokers, asymptomatic smokers, subjects with chronic expectoration, but normal ventilatory function and subjects with chronic expectoration and minimal obstructive ventilatory impairment. Low-level correlations were found (coefficients of less than 0.3) between delta He25% or volume of isoflow on one side and FEV1.0 or FEV1.0/VC. Some possibly confounding factors for these correlations are discussed. We conclude that density dependence variables are not consistently related to the FEV1.0 in subjects 'at risk' or with minimal airflow limitation.

Adult↗

Lung volume, chest size, and hematological variation in low-, medium-, and high-altitude central Asian populations.

To evaluate adaptive responses to high-altitude environment, we examined three groups of healthy adult males from Central Asia: 94 high-altitude (HA) Kirghiz subjects (3,200 m above sea level); 114 middle-altitude (MA) Kazakh subjects (2,100 m), and 90 low-altitude (LA) Kirghiz subjects (900 m). Data on chest size (chest perimeter and chest diameter), lung volume (forced expiratory volume (FEV) and forced expiratory volume in 1 sec (FEV1)), and hematological parameters (hemoglobin, erythrocytes, hematocrit, and SaO(2)) are discussed. The results show that 1) chest shape is less flat in the samples living at higher altitude. In the HA sample, chest perimeter is lower but chest excursion is high. 2) In the highlanders, forced vital capacity (FVC) and FEV1 are no higher than in the other samples, even when corrected for stature and body weight. The negative correlation between FVC-FEV1 and age decreases with increasing altitude. 3) The HA and MA samples have higher values of hemoglobin, erythrocytes, and hematocrit. The HA sample has lower SaO(2) and higher arterial oxygen content than the LA sample. No association between hematocrit and age was detected in the four samples. The results indicate that the high-altitude Kirghiz present features of developmental acclimatization to hypobaric hypoxia which are also strongly influenced by other major high-altitude environmental stresses.

Adaptation, Physiological↗