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PubMedDate not supplied

Primary cardiac malignancy presenting as left atrial myxoma. Clinical and surgical considerations.

Primary heart neoplasms occur in 0.002-0.3% of autopsies: 30% are myxomas and 20-30% are malignancies, almost always sarcomas. Cardiac metastases are 10 to 40 times more frequent than primary heart cancer. We describe a case of a left atrial sarcoma erroneously diagnosed as myxomas preoperatively. Standard surgical indication for resection of cardiac myxomas is based on echocardiography. Because of the severity of cardiac malignant lesions than can mimic atrial myxomas at echocardiography, through preoperative investigation should be accomplished, best by magnetic resonance imaging. In case of suspected malignancy, total body computed tomography should be performed to avoid unnecessary cardiac operations in case of disseminated cancer. To date the only good medium and long-term results in the therapeutic management of heart sarcomas have been achieved by transplantation: the probable explanation is that criteria of surgical radicality should be those followed for soft tissue tumors located elsewhere in the organism.

Diagnosis, Differential↗
PubMedDate not supplied

[Does heart sarcoma mimick lupus erythematosus and vasculitis? Report of 2 cases].

Primary heart tumors are rare. The most common one is myxoma. It may synthetize IL-6 and frequently shown systemic clinical manifestations that confuse the diagnosis. Primary heart sarcomas are even more rare, as far as we know they have been not associated with systemic illnesses. We observed two cases with a presumptive diagnosis of systemic lupus erythematosus who were identified as primary sarcomatous heart neoplasms after surgical excision.

Adult↗
PubMed1977

[Electron microscopic investigations on early stages of experimental heart tumours in rats (author's transl)].

The views on the histogenesis of experimental heart tumours in rats are controversal. Up to now electron microscopic investigations on early tumour stages are lacking. In this study ultrastructural findings of 4 early stages of heart neoplasms in the left ventricle of BD-IX rats are reported. Material and methods. BD-IX rats received repeated intravenous injections of methylnitrosourea in a dosage of 20 mg/kg body weight. After averagely 9 months the animals were killed by ether anesthesia. Sections of the heart were fixed in solution according to Karlsson and Schultz (1965). In order to discover early stages of tumours light microscopic examinations were carried out on heart sections. Afterwards the small tumour-containing tissue samples were postfixed in 1% OsO4, embedded in durcupan, and double contrasted with uranyl acetate and lead citrate. Results. Light microscopy (semithin sections): Beneath an endothelium-like cell layer an area of parallel to each other arranged spindle-shaped tumour cells with usually hyperchromatic nuclei was found. Some cells were larger and contained pale nuclei. Electron microscopy: The spindle-shaped neoplastic cells with irregular nuclei are loosely arranged. Most of the cells were surrounded by a basement membrane. In the extracellular space abundant thin cell processes and collagen fibers were demonstrable. The tumours contained characteristic bundles of cell processes as well as single processes which enveloped a virtual point of the space. Some large and widely undifferentiated tumour cells had stump-like thick processes. In the area of trabecular muscle neoplastic cells of an apparently mesenchymal origin were present. The ultrastructural findings are discussed regarding the histogenesis of the small heart tumours in the rats. They probably developed from neoplastic Schwann cells but an additional mesenchymal component seems to be engaged. Further studies are necessary to clarify the significance of both components and their relations in the experimental heart tumours.

Animals↗
PubMed2004

Left atrial cardiac hemangioma: a report of two cases.

Cardiac hemangiomas are exceptionally rare tumors with an incidence of 1 to 3% of all detected benign heart neoplasms. We report 2 cases of left atrial hemangioma of which only one associated with clinical symptoms such as dyspnea and palpitations. Two years following surgical excision of the tumors, there was no echocardiographic evidence of recurrence.

Aged↗
PubMed2003

Cavernous hemangioma of the tricuspid valve: minimally invasive surgical resection.

Cardiac hemangioma is a rare, benign vascular tumor, occurring with an incidence of 1% to 2% of all detected benign heart neoplasms. Hemangioma of the tricuspid valve has never been previously reported. We describe the successful excision of this tumor through a right anterolateral mini-thoracotomy in a 49-year-old woman. Competency of the valve was confirmed intraoperatively and at discharge by transesophageal echocardiography.

Female↗
PubMed2000

[Intracardiac metastasis of malignant melanoma. Literature review and case report].

The authors report the case of a 70 year old man with a past history of nucleation of the left eye thirty years previously, in whom two masses, one in the right atrium and the other in the left ventricle, were chance findings on transthoracic echocardiography. After surgery, during which the right atrial tumour was removed and the left ventricular tumour biopsied, histology confirmed the malignant melanomatous nature of the tumours. Further investigations did not detect a primary tumour or other secondary ones. The choroidal origin of these metastases cannot be excluded. After 5 years follow-up, the patient remains in good general condition and the tumours have not recurred or progressed. The literature is reviewed with reference to this case report.

Aged↗
PubMed2003

Non-Hodgkin's lymphoma of the brainstem with atrial septal mass.

Simultaneous occurrence of cardiac and central nervous system tumors have been rarely reported. A 23 years male presented to us with right cerebello-pontine (CP) angle symptoms and signs. Cranial imaging showed a mass lesion in the right pons infiltrating into the right and middle cerebellar peduncles. There was also a cardiac-atrial septal mass. The brainstem lesion was found to be a non-Hodgkin's lymphoma where as the cardiac lesion was not accessible. Central nervous system lymphomas are reported rarely and the prognosis is poor. The chances of the cardiac lesion in this patient also being a lymphoma are high, as it was a infiltrative cardiac mass, infiltrating the atrial septum.

Adult↗