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PubMed1959

Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice.

Cell-free filtrates of x-ray-induced lymphoid tumors of strain C57BL/ Ka mice have elicited, on injection into newborn isologous hosts, a lymphoma incidence of 15 to 19 percent. In control mice of the same subline, the incidence of spontaneous lymphoma is about 1 percent. No leukemogenic activity could be detected in filtrates from thymi harvested at 2 to 32 days following completion of x-ray treatment. Activity was evident at 64 days and was perhaps somewhat greater at 128 days. Serial cell-free passage of filtrates in newborn F(1) hybrid mice resulted in a marked increase in lymphoma incidence (69 percent), coupled with a shortening of the median latency. Supplementary x-irradiation failed to enhance the activity of filtrates after neonatal injection.

Animals↗
PubMed1960

Possible two-stage mechanism in experimental leukemogenesis.

The augmenting influence of urethan on leukemogenesis by x-radiation in mice has been found to operate when the urethan treatment follows the radiation, but not when the sequence is reversed. The result is in keeping with the idea that urethan acts as a promoting factor in leukemogenesis, as defined by the twostage mechanism hypothesis of carcinogenesis. It may also have a practical bearing on leukemia development in man.

Animals↗
PubMed1961

Leukemogenesis by urethan in C57B1 mice bearing isologous tissues from x-irradiated mice.

A single exposure of mice of a low-leukemic strain (C57B1/6) to 400 r of total-body x-irradiation caused the early appearance of a factor which, though not itself capable of inducing leukemia in adult C57B1 recipients, did cause its appearance when the recipients also received urethan by injection. Positive results were obtained with seven different tissues from irradiated animals, whether urethan was injected 1 day or 30 days after the irradiation. No such effect was obtained in either series in the absence of urethan treatment. When urethan was injected into normal C57B1 mice, or into mice previously implanted with tissues from nonirradiated mice, only marginal leukemogenic activity was evinced. The possible involvement of a precursor virus is discussed.

Animals↗