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At least 109 records · Page 6Linked to original sources
PubMed1977

New library buildings: the Houston Academy of Medicine--Texas Medical Center Library.

A historical account is given of the Houston Academy of Medicine--Texas Medical Center Library within its Texas Medical Center setting in Houston, Texas. Outlined are planning, financing, and construction of the new library, which consists in part of new building and in part of renovated interiors of an old building originally completed in 1954. A concise picture is given of the new library's interiors, showing its functional success for users and employees alike. An architectural summary is appended showing gross and net footages, source of funds, costs and capacities.

Facility Design and Construction↗
PubMed1998

Gridded genomic libraries of different chordate species: a reference library system for basic and comparative genetic studies of chordate genomes.

The use of genomic libraries maintained in arrayed format is becoming a more and more popular tool for the analysis of molecular evolution and comparative molecular development. Being able to use already existing reference libraries considerably reduces the work load, and if results are made publicly available, it will facilitate in silica experiments in the future. Here we describe the construction and preliminary characterization of six cosmid libraries of different chordate species, Ciona intestinalis (Hemichordate), Branchiostoma floridae (Cephalochordate), Lampetra fluviatilis (Cyclostoma), Xiphophorus maculatus, and Danio rerio (Osteichthyes) in Lawrist7 and Fugu rubripes in Lawrist4.

Animals↗
PubMed1992

Who uses NHS libraries? Preliminary results from a survey of postgraduate medical libraries in North East Thames.

Recent changes have made Regional Deans fund-holders for postgraduate medical education. Allocations from the Dean's budget often fund NHS library infrastructure and associated costs arising from the information and study needs of junior medical staff. To provide adequate levels of stock and services for all library users requires funding from all appropriate sources. This paper describes a survey carried out in North East Thames to facilitate appropriate funding by and for user groups other than junior doctors. The wide variation in results is discussed. The survey is not seen as definitive, but as part of the beginning of the evolutionary process of allocating funds for libraries serving postgraduate medical education and other users. Further research is suggested, particularly in other Regions, to provide comparative data.

Education, Medical, Continuing↗
PubMed1981

Selective medical libraries and library networks for developing countries.

The growth and rising cost of bibliographic materials require that attempts to make all medical libraries comprehensive and self-contained be replaced by the provision of selective collections devoted to the most used and useful materials, particularly in developing countries with limited resources. Journals constitute the most important and expensive component of a biomedical collection. While use data are important, a method is presented to guide selection in the absence of this information. The method identifies 35 nucleus journals and uses citation analysis to generate a list of 92 journals, partitioned into 31 medical specialty classes. Local expert consensus can guide selection of important local or regional literature not in the international archives. Careful selection results in efficient collections. Access to less used materials can be provided to individual libraries through resource sharing networks with affiliations to major comprehensive international libraries.

Developing Countries↗
PubMed1997

Costing the library services. Cairns Library: a case study.

In the present climate libraries have to adopt a business approach to funding submissions; detailed management information must be produced in support of expenditure and to ensure that the services are cost-effective. In addition to the grant from its parent body (the Faculty of Clinical Medicine, University of Oxford), the Cairns Library obtains funding from five other bodies, including National Health Service Hospital Trusts. The Cairns Library has introduced an ongoing costing exercise covering the different services. The costs are divided into three categories: salary costs, other direct costs and indirect costs. Staff time has been identified from detailed time-sheets kept by each member of staff; the time recorded is assigned to the individual services. The direct costs and the indirect costs have been identified and allocated/apportioned similarly. The services are divided into five packages: core, current awareness, document delivery, enquiries and user education. The costs for each package have been apportioned to the funding bodies on the basis of the number of registered users from each body.

Cost Allocation↗
PubMed1967

Steps towards a computer-based library network: a survey of three medical libraries.

The introduction of a computerized biomedical network in three medical libraries in the State University of New York demanded a study of the various bibliographic records held by the libraries. The investigation produced figures relating to the total number of monographs held by each library and the number of unique titles owned by the network as a whole. These were broken down to identify the amount of works dating from 1962 or later, and estimates were made of the mean length of the normal bibliographic record, as well as of its traditional subareas. Thought was given to the implication of applying depth-indexing to monographs with reference to the length of the record.

Computers↗
PubMed1993

Anchor-ligated cDNA libraries: a technique for generating a cDNA library for the immediate cloning of the 5' ends of mRNAs.

A new, efficient and simple method based on single-stranded anchor ligation has been developed that allows for the generation of an anchor-ligated library from which the 5' ends in many mRNAs can be cloned. Random hexamers are used to prime poly A+ RNA for the first strand synthesis of a cDNA library, and a modified single-stranded anchor is then ligated to the 3' end of the cDNA using T4 RNA ligase. The library can then be used to amplify the 5' end of any mRNA expressed in the tissue. The efficiency and utility of this method has been demonstrated by amplification of three human genes: transferrin receptor, tissue-type plasminogen activator and beta actin.

Actins↗
PubMed1976

New library buildings. Part VII. The Health Sciences Library of the University of Virginia.

This article describes the new Health Sciences Library at the University of Virginia Medical Center in Charlottesville, Virginia. The library was under construction for about two years and opened in August 1975. It comprises an area of 66,250 sq. ft. gross, almost 44,000 sq. ft. net, and provides space for approximately 190,000 volumes, 500 readers, and a staff of 35. The cost of construction was $2,350,000, plus approximately $400,000 for furnishings and equipment. A portion of the library is located on a bridge spanning a four-lane highway. Special features include a 6,000 net sq. ft. audiovisual information center, Elecompack (TM) motorized shelves for little-used materials, and a closed-circuit television surveillance system.

Facility Design and Construction↗
PubMed1976

New library buildings. Part VIII. The Library of the Health Sciences, University of Illinois at the Medical Center, Chicago.

The new Library of the Health Sciences at the University of Illinois at the Medical Center is described and illustrated. The building was under construction for thirteen months, using phased construction techniques, and opened in October 1973. The library is a self-contained and physically independent building consisting of three levels above ground and one lower level, comprising an area of 130,000 sq. ft. gross and 88,000 sq. ft. net. The building provides space for 350,000 volumes, 1,037 readers, and a staff of 100. The cost of construction was $5,140,500 plus $858,500 for furnishings and equipment. Among the special features are a twenty-four-hour multimedia services department and a full-circulating style book detection system. Included in the article is an evaluation of the library after two years of occupancy.

Chicago↗
PubMed1971

The regional medical library and the hospital library.

A description of the origin of the Regional Medical Program is given and of regional service activities. Among the topics discussed are interlibrary loans, MEDLARS searches, orientation of librarians and library users, including workshops and the library Core collection, and the evaluation of needs for biomedical information in the regions.

Information Services↗
PubMed1998

Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures.

A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.

Biphenyl Compounds↗
PubMedDate not supplied

Solution-phase synthesis of a 1,5-dialkylamino-2,4-dinitrobenzene library and the identification of novel antibacterial compounds from this library.

In this report we demonstrate that a 1,5-dialkylamino-2,4-dinitrobenzene small molecule library can be generated by a highly efficient solution-phase synthesis method. From this 2485-member library, a series of novel compounds with antibacterial activity were isolated. The significance of this report is that the synthetic scheme is extremely simple, with minimal number of liquid handling steps, and the solvents and reagents left in the final library preparation are fully compatible with cell-based assays.

Anti-Bacterial Agents↗
PubMedDate not supplied

Microwave parallel library generation: comparison of a conventional- and microwave-generated substituted 4(5)-sulfanyl-1H-imidazole library.

A methodology for the microwave parallel synthesis of libraries is described. The procedure involves the use of an array of expandable reaction vessels, which can accommodate pressure buildup within the vessel due to heating without loss of volatile solvents or reagents. A demonstration 24-membered library of substituted 4(5)-sulfanyl-1H-imidazoles was generated by both conventional and microwave procedures, achieving a reduction from 12 h to 16 min in library generation time for the microwave approach.

Combinatorial Chemistry Techniques↗
PubMed1989

PCR-based cDNA library construction: general cDNA libraries at the level of a few cells.

A procedure for the construction of general cDNA libraries is described which is based on the amplification of total cDNA in vitro. The first cDNA strand is synthesized from total RNA using an oligo(dT)-containing primer. After oligo(dG) tailing the total cDNA is amplified by PCR using two primers complementary to oligo(dA) and oligo(dG) ends of the cDNA. For insertion of the cDNA into a vector a controlled trimming of the 3' ends of the cDNA by Klenow enzyme was used. Starting from 10 J558L micron3 myeloma cells, total cDNA was synthesized and amplified approximately 10(5) fold. A library containing 10(6) clones was established from 1/6 of the amplified cDNA. Screening of the library with probes for three genes expressed in these cells revealed a number of corresponding clones in each case. The longest obtained clones contained inserts of 1.5 kb length. No sequences originating from carriers or from rRNA was found in 14 randomly picked clones.

Cloning, Molecular↗
PubMedDate not supplied

Recommendations for responsible monitoring and regulation of clinical software systems. American Medical Informatics Association, Computer-based Patient Record Institute, Medical Library Association, Association of Academic Health Science Libraries, American Health Information Management Association, American Nurses Association.

In mid-1996, the FDA called for discussions on regulation of clinical software programs as medical devices. In response, a consortium of organizations dedicated to improving health care through information technology has developed recommendations for the responsible regulation and monitoring of clinical software systems by users, vendors, and regulatory agencies. Organizations assisting in development of recommendations, or endorsing the consortium position include the American Medical Informatics Association, the Computer-based Patient Record Institute, the Medical Library Association, the Association of Academic Health Sciences Libraries, the American Health Information Management Association, the American Nurses Association, the Center for Healthcare Information Management, and the American College of Physicians. The consortium proposes four categories of clinical system risks and four classes of measured monitoring and regulatory actions that can be applied strategically based on the level of risk in a given setting. The consortium recommends local oversight of clinical software systems, and adoption by healthcare information system developers of a code of good business practices. Budgetary and other constraints limit the type and number of systems that the FDA can regulate effectively. FDA regulation should exempt most clinical software systems and focus on those systems posing highest clinical risk, with limited opportunities for competent human intervention.

Clinical Medicine↗
PubMed1999

Powerful connections for public health: the National Library of Medicine and the National Network of Libraries of Medicine.

As incorporated in Healthy People 2010 objectives, data and information systems and a skilled workforce are 2 of the critical components of the public health infrastructure. The National Library of Medicine (NLM) and the National Network of Libraries of Medicine (NN/LM) are important resources for improving Internet access and providing related training to the public health workforce and to those in training for public health careers. The NLM and the NN/LM have joined forces with the Centers for Disease Control and Prevention, the Health Resources and Services Administration, the Association of State and Territorial Health Officials, the National Association of County and City Health Officials, and the Public Health Foundation. The goal of this collaboration is to improve electronic resources useful in public health practice and increase awareness of them, to train public health professionals to use electronic information services, and to help public health agencies obtain the equipment and Internet connections needed to use these services effectively. The databases, outreach programs, and connection grants available to public health professionals from the NLM, and the training and ongoing support available from the NN/LM for accessing these programs and services, are described.

Centers for Disease Control and Prevention, U.S.↗