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At least 109 records · Page 6Linked to original sources
PubMed1996

Evaluation of the effect of zinc acetate on the stratum corneum penetration kinetics of erythromycin in healthy male volunteers.

Erythromycin with or without additional zinc acetate is used topically in the treatment of acne vulgaris. A potential effect of zinc on the stratum corneum penetration of erythromycin was investigated in human volunteers. Skin surface washings and tape strippings from the skin of the back were collected after drug applications in 12 subjects for quantification of erythromycin levels. Zinc acetate increased the amount remaining on the back skin at 6 h after application from 40 +/- 19 to 56 +/- 15% of the dose and, vice versa, reduced the amount in stratum corneum strips from 22 +/- 7 to 18 +/- 7%, both with statistical significance. The effect varied with body region. Zinc acetate thus provided to prolong the residence time of erythromycin on the skin.

Acetates↗
PubMed2005

Mother's milk and the muffin man: grassroots innovations in medical marijuana delivery systems.

In the ongoing debates over medical marijuana, opponents often conflate the alleged risks of cannabis therapeutics with the acknowledged harms associated with smoking. Although smoking is the most widely used method of administering marijuana, it is not the only available means. This paper provides an account of the production, distribution, and administration of non-smokable cannabis products by members of a California health care collective, the Wo/Men's Alliance for Medical Marijuana. WAMM has developed a variety of alternative methods of administering cannabis orally and externally that challenge the rhetorical equivalence between smoking as a delivery method and botanical marijuana as a medicine. Their experience with low-cost and low-tech production techniques has enabled even the poor and uninsured among them to manage the debilitating symptoms of their illnesses and the side-effects of their often onerous courses of treatment, without smoking. The organization provides an informative example of.

Beverages↗
PubMed1977

Camphorated and castor oil confusion and its toxic results.

Three cases of camphorated oil ingestion occurring over a 20-month period are discussed. Two of the three ingestions resulted in hospitalization, and the clinical course of the ingestions are presented. Follow-up investigations were performed to determine the causes of the confusion between castor and camphorated oil. Also presented are descriptions of efforts made to improve labeling and packaging of this potentially lethal household product.

Adolescent↗
PubMed1987

Studies on the antimycotic activity of 5-fluoroorotic acid.

The antimycotic effect of 5-fluoroorotic acid (FOA) was studied in experimental and clinical conditions. The experiments in vitro were performed on 21 strains of fungi isolated mainly from clinical material. The effect of FOA was compared with those of the structurally related drug 5-fluorocytosine. The clinical study was performed on 40 patients aged 18 to 75 years with mycological diseases. FOA in different dosage forms was applied topically 2 to 3 times daily for 30 days. Microscopic and cultured mycological studies were performed before and after treatment. The results showed that FOA possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects. Clinical studies of 1% FOA cream showed good therapeutic effects similar to that of Ung. Whitfield, but 55% of the patients developed relapse of the lesions after discontinuation of the treatment. Higher concentrations of FOA included in milk suspension and powder induced severe side effects of local irritability.

Adolescent↗