PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “METHYL CHLORIDE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 109 records · Page 6Linked to original sources
PubMed1986

Methyl chloride.

Explore the source record for details and available documents.

Animals↗
PubMed1986

Studies on the inhibition of brain synaptosomal Na+/K+-ATPase by mercury chloride and methyl mercury chloride.

The effect of mercury chloride (HgCl2) and methyl mercury chloride (MeHg) on brain synaptosomal Na+/K+-ATPase was determined in vitro. It was shown that HgCl2 is a more powerful inhibitor than MeHg. The IC50 were 5 X 10(-7) M for HgCl2 and 2.3 X 10(-6) M for MeHg. A non-competitive type of inhibition was observed with the two mercurials. Removal of contaminating lipids with the non-ionic detergent Lubrol did not affect the inhibition of either mercurial. It is concluded that non-essential lipids do not play a significant role in the inhibitory effect of MeHg and that the potency of these mercurials on to inhibit brain synaptosomal Na+/K+-ATPase largely depends on their capacity to block sulfhydryl groups.

Animals↗
PubMed1989

Different histochemical findings in the brain produced by mercuric chloride and methyl mercury chloride in rats.

The chemical form of mercury reactive by the histochemical technique was studied by using rats and mice treated with mercuric chloride (HgCl2) and methyl mercury chloride (MeHgCl). Mercury granules were demonstrated histochemically in the brain of HgCl2-treated rats with higher levels of inorganic mercury. However, mercury granules were not demonstrated in the brain of MeHgCl-treated rats in spite of a considerably high organic mercury level. In rats and mice with significant biotransformation of injected MeHg to inorganic mercury, the appearance of the peak inorganic mercury level and mercury granules in the brain seemed to occur on the same day. These results suggested that mercury granules in the brain represent inorganic mercury, but not organic mercury. In the brains showing mercury granules, the lowest level of inorganic mercury was 0.12 micrograms/g in HgCl2-treated rats, 0.14 micrograms/g in MeHgCl-treated rats, and 0.12 micrograms/g in MeHgCl-treated mice. These values were similar to the level of inorganic mercury in the brain from human autopsy cases. Mercury granules were demonstrated histochemically in nerve cells, choroid plexus and phagocytes in the brain of both HgCl2-and MeHgCl-treated rats, and in ependyma of MeHgCl-treated rats. The level of inorganic mercury of the brains showing mercury granules in phagocytes was lower in MeHgCl-treated rats than in HgCl2-treated rats. The numbers of mercury granules in nerve cells increased with the rising level of inorganic mercury in the brain of MeHgCl-treated rats.

Animals↗