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The epigenetic impact of weaning on craniofacial morphology during growth.

Miniature pigs (Sus scrofa) were used as a model to investigate whether the time of weaning (a nongenetic factor) affects skeletal growth rates for both pre- and postweaning time periods. Control litters were weaned at the normal time of 32 days. Two litters were weaned early (at 20 days) and two late (at 46 days). We digitized cranial landmarks from radiographs taken three times a week for a total of 70 days. We used analysis of covariance to test for differences in growth rates between pre- and post-weaning periods, as well as differences in growth rates among treatments. In both the late weaned pigs and the controls, facial length, facial width, basicranial length, and basicranial width growth rates slowed significantly at the time of weaning. However, in the early weaned pigs, there were no significant changes in growth rates for any of the facial or basicranial measurements at weaning. Furthermore, the postweaning rates of growth were different among treatments. One possible implication is that early growth rates could be under tight genetic control while later growth rates can be epigenetically regulated through nutritional changes.

Aging↗

The current understanding of cleft lip malformations.

Cleft lip with or without cleft palate is one of the most common congenital malformations. Epidemiology differentiates between cleft malformations connected with syndromes and the more common nonsyndromic forms not associated with other deformities. Although many syndromes with cleft lip with or without cleft palate are known, the majority of orofacial clefts are of the nonsyndromic form. These are known to be of multifactorial origin, with both environmental and genetic factors in their etiology, most of which remain to be fully investigated. Recent literature reveals that wide ethnical and racial variations in the occurrence of cleft lip and/or palate exist. The purpose of this overview is to show the current standing of research in this field. Genetics, environmental factors, and morphogenesis of the primary and secondary palate in normal development and cleft malformations are especially emphasized.

Animals↗

The validity of experimental evidence.

Commonly the assumption is held that correct data only and always will lead to valid deductions. However, analysis of the literature reveals striking examples of erroneous conclusions based upon correct data. The present article intends to show that meticulously performed research in itself is no guarantee for correct conclusions. It appears that investigators, together with the "scientific forum" of their time, interpret the results of experiments in the light of accepted viewpoints, without challenging other or less likely explanations. And since this has happened to the best of us in the past, it is also apt to happen to us today.

Animals↗

[Physical development and teeth age of children aged 7-10 years].

The reported stomatological and paediatric examinations were carried out in 876 children aged 7-10 years. In the studied material accelerated eruption of permanent teeth coexisted with excessive body mass or height, and delayed eruption was related to below normal body mass and height.

Body Height↗