[THE TREATMENT OF ACROMEGALY].
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The authors represent the results of the treatment of 20 children with Itsenko-Cushing disease (ICD) by proton-beam irradiation of the pituitary body. The use of the medical proton beam of the Institute of Theoretical and Experimental Physics was found to be effective for the treatment of children with mild and average forms of ICD. Irradiation of the pituitary gland at a dose of 70-100 Gy is accompanied by general and local radiation reactions which are not dangerous for children. The time of development of remission after irradiation depends on a degree of severity and features of a course of disease.
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The effect of conventional radiotherapy on the TRH response was studied in fourteen patients, all but one previously surgically treated for pituitary tumors. No change in the TSH response to TRH could be observed either during or after a four week treatment period, thus demonstrating relative resistance of the pituitary gland against irradiation in these patients. We also conclude that the diagnostic value of the TRH test remains unhampered during and in the immediate period after irradiation.
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