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Sedation procedures in MR imaging: safety, effectiveness, and nursing effect on examinations.

PURPOSE: To measure the safety and effectiveness of conscious sedation in order to assess utilization and the effect on magnetic resonance (MR) imaging examinations. MATERIALS AND METHODS: A database of conscious sedation records for MR imaging at the Johns Hopkins Hospital, Baltimore, Md, from 1991 to 1998 was searched. Safety data according to medication and procedure duration for each nurse were tabulated for 6,093 patient records. Data were analyzed by using quality control statistical measures to determine time utilization and effectiveness. Break-even costs for the procedure were determined. RESULTS: Of 6,093 patients scheduled for examination, 4,761 patients (78.1%) received conscious sedation by the MR conscious sedation service. Complications were observed in 20 of the 4,761 patients (0.42%). No deaths occurred. The most common complication was oxygen desaturation (n = 8). Diagnostic and complete MR examinations were performed in 4,453 of the 4,761 patients (93.5%). The mean time to sedate the patient (+/- SD) was 23.6 minutes +/- 15.2 for specialized MR sedation nurses and 26.8 minutes +/- 20.1 for general radiology nurses (P: <.001). For inpatient nurses from the inpatient hospital units, the sedation time was considerably longer (47.3 minutes +/- 36.6, P: <.001) and more variable. Break-even costs were 37% ($11 vs $8 for MR room time) more for general radiology nurses than for specialized MR sedation nurses performing the procedure. CONCLUSION: Conscious sedation is safe and has a high effectiveness rate. A highly specialized nursing staff reduces procedure variability and cost.

Adolescent↗

A method for measuring system safety and latent errors associated with pediatric procedural sedation.

The practice of sedating patients in the hospital for diagnostic and therapeutic procedures may be associated with life-threatening respiratory depression. We describe a method that uses a simulated event to identify latent system failures. A simulated scenario was developed that was reproducible with realistic physiology that degraded over time if no interventions occurred and improved when treated appropriately. Management of the scenario was observed in an ideal setting, a radiology department, and an emergency department. Event management was videotaped. The simulator's physiological data were saved automatically at 5-s intervals. Deviations from "best practice" were measured by using a set of video markers for event detection, diagnosis, and treatment. The simulator data files were used to calculate time out of range for critical variables. Hypoxia and hypotension lasted 4.5 and 5.5 min in the radiology and emergency departments, respectively, compared with 0 min in the gold standard setting. Many latent failures were identified by reviewing the video. This study supports the feasibility of using available human simulation as a crash-test dummy to more objectively quantify rescue system performance in actual sedation care settings. This method revealed vulnerabilities in personnel and in care systems even though sedation care regulatory requirements were met.

Anesthesiology↗

Procedural sedation and analgesia in the emergency department: what are the risks?

The practitioner of emergency medicine is routinely faced with patients in need of emergent procedures and pain control and sedation. Our challenge is to make our patients' experiences as painless and as safe as possible, while maximizing our ability to perform the procedure at hand; this is not always an easy task given the propensity of each human body to react differently to interventions and stimuli. We can best meet this challenge by understanding how our patients and pharmaceutical agents intermingle in the risk-benefit equation we formulate before starting our "experiment." Coupling this information with fundamentally sound patient care and monitoring will minimize bad experiences with PSA for both the patient and practitioner.

Adverse Drug Reaction Reporting Systems↗

Etomidate for procedural sedation in the emergency department.

STUDY OBJECTIVE: To review our experience with etomidate in nonintubated patients in the emergency department. DESIGN: A 2-year retrospective chart review of consecutive patients receiving etomidate for sedation. SETTING: Emergency department of a university-based teaching hospital. PATIENTS: Forty-eight patients who underwent painful procedures in the emergency department. MEASUREMENTS AND MAIN RESULTS: Demographics, dosing information, recovery times, and adverse events were abstracted using a standardized data collection form. Forty-eight nonintubated patients were sedated with etomidate. Mean age was 34 years (range 6-80 yrs); 38 were men and 10 women; two were children. The mean initial dose of etomidate was 13 mg. Adverse events occurred in 11 (21%) patients. None sustained any substantial morbidity as indicated by need for intubation, prolonged emergency department stay, or hospital admission. CONCLUSION: Although controversial, etomidate holds promise as a potent sedative agent for patients undergoing painful procedures in the emergency department. A large prospective evaluation is needed to document the performance and complications of this agent.

Adolescent↗

Intravenous procedural sedation: an alternative to general anesthesia in the treatment of early childhood caries.

Providing comprehensive dental treatment for preschool children with early childhood caries (ECC) is probably the greatest challenge facing most dentists; many elect to hospitalize a child with ECC and provide treatment under general anesthesia. However, as waiting lists for hospital admission are long, ECC continues to progress and can cause pain or acute infection. Hospital treatment also results in substantial costs beyond those for dental treatment. This paper describes a cost-effective intravenous sedation program being used in a pediatric dental practice in Kelowna, British Columbia. The program offers an alternative to general anesthesia that allows qualified dentists to provide comprehensive dental treatment to children with ECC safely and efficiently in the private practice setting.

Anesthesia, Dental↗

Comparison of meperidine plus midazolam and fentanyl plus midazolam in procedural sedation: a double-blind, randomized controlled trial.

This double-blind, randomized, prospective study was conducted to compare the analgesic and sedative efficacy of fentanyl and meperidine in orthopedic closed reduction of fractures and dislocations undertaken in the emergency department. Seventy consecutive adult patients with fractures or dislocations suitable for reduction were randomized to receive fentanyl (1 mcg/kg; n = 36) or meperidine (0.5 mg/kg; n = 34) in combination with midazolam (0.02 mg/kg). Vital signs and alertness scale scores of the patients were monitored. The Visual Analog Scale (VAS) was used to determine the degree of pain. There was no statistically significant difference between the VAS mean scores of the fentanyl and meperidine groups (t test, P = .772). The need for additional analgesic drugs was significantly more frequent in patients receiving meperidine (P = .018). No adverse events, such as hypotension or respiratory depression, were noted. Euphoria occurred in one patient in the fentanyl group. Although dose requirements differ, fentanyl and meperidine provide effective and reliable analgesia in closed reduction of fractures and dislocations.

Adult↗

Procedural sedation.

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Administration, Inhalation↗