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A computerized system for localization of diabetic lesions from fundus images.

A computerized system for the localization of diabetic lesions from fundus photographs is described. The coordinates for each lesion in relation to reference points are determined from fundus images projected on a digitizing table. The program accepts some variation in coordinates for a single lesion, still to be recorded as the same lesion in a series of photographs, and the magnitude of this variation is adjustable. The data obtained from the localization program are transferred to a register program yielding the following parameters: number of lesions, new lesions, lost lesions, variable lesions, time of presence for lost lesions. These data can be further exported into Microsoft Excel 4, for analysis of large patient materials. An intra-observer error of 0% and an inter-observer error of 1.1% was found in localization of lesions from fundus images. The program was insensitive to small variations in the fundus pictures, but comparisons of 30 degrees and 60 degrees photographs of the same fundus, or 20 degrees deviation of gaze, induced identification errors in 2.9% and 11.9% of localizations, respectively. With this system new parameters on diabetic fundus images can be obtained. The significance of these parameters in the progression of diabetic retinopathy will be analyzed in further studies.

Aneurysm↗

MacPROT: a set of BASIC programs for protein structure analysis.

MacPROT is a set of seven interactive application programs and a coordinating menu for storing, editing, and analysing protein sequences. Analyses for hydropathy, amphilicity, helix wheel, and dot matrix comparison are plotted as graphs on the screen and can be printed immediately or transferred to a picture accepting program. Programs are written in BASIC for the Apple 512 kbyte Macintosh. The source code is accessible and can be adapted to other machines.

Amino Acid Sequence↗

Performance in occupational therapy as a predictor of successful prevocational training.

Scores on three subtests of the Minnesota Follow-up Scale (MFS) were related to client outcomes in a prevocational training program in a study of 26 clients who were referred from an adult psychiatric day treatment unit. The results of the study agreed with a prediction that successful performance in occupational therapy in the day treatment unit, as measured by subtest 1, would be significantly related to successful client outcomes. the results regarding predictions for two other subtests were less conclusive because clients received high scores. Age and sex distributions showed that the younger male clients were most likely to be referred for prevocational training. The staff of the prevocational training program accepted the results of the study and also agreed that performance in occupational therapy (in the day treatment unit) should receive greater recognition by staff members as an important indicator of work potential when evaluating clients for referral to a vocational training program. It is planned to continue the use of the MFS in the day treatment unit as an aid for evaluating clients for referral purposes. Scores will continue to be related to client outcomes in the prevocational training program. Further study is also planned concerning the relationship of age and sex and sources to which clients are discharged or referred from the day treatment unit.

Adult↗

A BASIC program for serum cholinesterase phenotyping using a microcomputer.

We have modified a BASIC program for serum cholinesterase phenotyping using a microcomputer. This program accepts the reaction-rate result of total and inhibitor assays of activity, allows the patient to be identified and prints out a full account of the fitting process thus allowing adequate documentation. We believe that this modification enhances the usefulness of the program to laboratories engaged in the routine determination of serum cholinesterase phenotyping.

Cholinesterases↗

The PRIME curriculum. Clinical research training during residency.

AIM: The Primary Medical Education (PRIME) program is an outpatient-based, internal medicine residency track nested within the University of California, San Francisco (UCSF) categorical medicine program. Primary Medical Education is based at the San Francisco Veteran's Affairs Medical Center (VAMC), 1 of 3 teaching hospitals at UCSF. The program accepts 8 UCSF medicine residents annually, who differentiate into PRIME after internship. In 2000, we implemented a novel research methods curriculum with the dual purposes of teaching basic epidemiology skills and providing mentored opportunities for clinical research projects during residency. SETTING: Single academic internal medicine program. PROGRAM DESCRIPTION: The PRIME curriculum utilizes didactic lecture, frequent journal clubs, work-in-progress sessions, and active mentoring to enable residents to "try out" a clinical research project during residency. PROGRAM EVALUATION: Among 32 residents in 4 years, 22 residents have produced 20 papers in peer-reviewed journals, 1 paper under review, and 2 book chapters. Their clinical evaluations are equivalent to other UCSF medicine residents. DISCUSSION: While learning skills in evidence-based medicine, residents can conduct high-quality research. Utilizing a collaboration of General Internal Medicine researchers and educators, our curriculum affords residents the opportunity to "try-out" clinical research as a potential future career choice.

Authorship↗

Automated measurement of transplantable solid tumors using digital electronic calipers interfaced to a microcomputer.

Data collection for transplantable solid tumors has been automated with electronic digital calipers and a balance which have been coupled through an RS-232 interface to a microcomputer. BASIC programs handle data entry, calculations and data storage. A "PROTOCOL" program accepts keyboard input of sample name, notebook number, submitter and dose along with necessary information on tumor system, and then initial animal weights for treatment groups are sent from balance to computer. Data is stored as an ASCII file on floppy disks, and protocol reports are printed. When the test is to be measured, a "MEASURE" program prompts the user for keyboard entry of toxic deaths in each group. Then the computer requests input of width and length of tumors for each animal. These tumor dimensions are sent to microcomputer by pressing a button on the calipers. When a group is completed, final animal weights are sent from balance to microcomputer. Then tumor weights and percent inhibition as compared to appropriate control groups are calculated, and the data is appended to the file for that test. A hard copy is generated as tumors are measured, and reports including percent inhibition can be printed immediately after a test is measured. The data as an ASCII file is transferred via modem to mainframe computer, where another program transfers the information to a database management program. These automated procedures for tumor measurement save time and lessen the chance for error by eliminating manual recording of solid tumor dimensions and subsequent reentry of this data for calculation.

Animals↗

Factors influencing recruitment to an occupational fitness program.

Factors influencing participation in an employee fitness program have been studied in a group of 535 early recruits for a Health Fitness Center established at the headquarters office of a larger corporation. The overall participation rate (20% of eligible staff with convenient access to the facility) was much as in previous reports. Interest was relatively equal in men and in women. Typical recruits were middle-aged non-smokers who had previously been active elsewhere. Men had an above average maximum oxygen intake and muscle strength, but were also somewhat overweight and fat. Women were closer to their actuarial ideal weight, but had relatively lower levels of cardiorespiratory and muscular fitness than the men. Program acceptability factors (traveling time, hours of work, and cost) had little effect on participation. Subjects perceived that they were active for health, fitness, competition (men), and appearance (women). General and specific health beliefs were well-developed, but bore surprisingly little relationship to health practices and outcomes. It is thus argued that the shaping of attitudes by trial of an exercise program may be a more effective tactic for increasing exercise participation than general campaigns designed to change attitudes and values.

Adult↗

Family crisis care: a home-based intervention program for child abuse.

Community awareness of child abuse and neglect has greatly increased. The documentation of an upward trend in the number of reported and confirmed child abuse and neglect cases in Hawaii reflects the need for additional programs to respond to this growing concern. Clinical nurse specialists in psychiatric and mental health nursing have developed an intensive home-based crisis interaction and family education program, Family Crisis Care. The program accepts only families referred by Child Protective Services in which at least one child is in imminent danger of being placed in foster, group, or institutional care. The goal of Family Crisis is to prevent the out-of-home placement of children through intensive, in-home intervention and to teach families new problem-solving skills to prevent future crises. The program has been effective in maintaining the child within the home, reducing physical punishment and other problem factors in the family, improving communication and problem-solving skills, and increasing use of community resources.

Adult↗

A home care program for children with chronic illness.

Pediatric Home Care (PHC) of Albert Einstein College of Medicine was designed as a special ambulatory care unit for children who are seriously or chronically ill and whose needs were not being met successfully through conventional programming. Services include: monitoring the patient's care: delivering direct services in the home, clinic, and hospital; teaching therapeutic programs to the family and patient; coordinating services; patient advocacy; health education; and supportive counseling. Each patient has a core team consisting of a generalist pediatrician, a PNP, and the patient's family. Visits are provided in the patient's home as needed, as well as in the traditional locations of the clinic, the inpatient units, and the PHC office. The program accepts patients with serious medical problems and who face any of a series of other difficulties, including: especially complex management problems that cannot be handled well in the customary outpatient settings; unstable family settings; or extended hospitalizations. Because it is not restricted to any single type of disease, the PHC provides a model that is applicable in a wide range of medical and community settings. Results of a program evaluation show that PHC is an effective intervention that has positive mental health outcomes and improves satisfaction with care.

Child↗

Residential program characteristics for completion of treatment by adolescent drug abusers.

The relationship to treatment outcome (as measured by the National Institute of Drug Abuse Client-Oriented Data Acquisition Process [NIDA-CODAP] Reasons for Discharge classification) of specific characteristics and elements of 22 drug-free residential programs for adolescents is reported. Admission and discharge data were obtained from NIDA-CODAP on 2,532 adolescents in the 22 programs. A partial cross-validation study was conducted by analyzing separately for two annual client subsamples. The program, not the individual client, was the unit of analysis. When three differences between programs in their client populations were "partialed out" the following characteristics of programs were found to predict positively to outcome (a lower treatment failure rate) to a statistically significant degree: the number of years that the counselors had worked in the programs; the number of volunteer staff in direct service (client contact); the proportion of clients receiving bodily and mental relaxation techniques: the counselors' perceptions that their programs accept or encourage relatively more spontaneous personal expressiveness, including expression of anger by clients, in staff-client relationships, but encourage less client "autonomy" (to be self-sufficient and independent with regard to making their own decisions); the counselors report that providing practical assistance in solving clients' real-life problems is useful. There was a high degree of replication of these findings across the two annual subsamples of clients. These findings for adolescents in residential programs are compared with findings reported in a parallel study of treatment outcome for adolescents in outpatient programs.

Adolescent↗

Guidelines for using standardized outcome measures following addictions treatment.

Increasingly, program managers are incorporating existing standardized tests as part of outcome evaluation. This article identifies guidelines for selecting and using standardized measures following addictions treatment. The principles identified in this context, however, are not only applicable to addictions treatment evaluation but also to the use of standardized measures in outcome evaluation of health programs generally. These guidelines cover eight basic criteria for selecting outcome measures: validity, sensitivity to measuring change, suitability for type of clients in the program, acceptability, clinical usefulness, ease of administration, scoring, and low cost. The article also discusses uses of outcome data, comparison of monitoring client outcomes to other forms of evaluation, and some practical issues related to using standardized outcome measures, including selecting what to measure and interpreting results.

Data Collection↗

A systematic review of faculty development initiatives designed to improve teaching effectiveness in medical education: BEME Guide No. 8.

BACKGROUND: Preparing healthcare professionals for teaching is regarded as essential to enhancing teaching effectiveness. Although many reports describe various faculty development interventions, there is a paucity of research demonstrating their effectiveness. OBJECTIVE: To synthesize the existing evidence that addresses the question: "What are the effects of faculty development interventions on the knowledge, attitudes and skills of teachers in medical education, and on the institutions in which they work?" METHODS: The search, covering the period 1980-2002, included three databases (Medline, ERIC and EMBASE) and used the keywords: staff development; in-service training; medical faculty; faculty training/development; continuing medical education. Manual searches were also conducted. Articles with a focus on faculty development to improve teaching effectiveness, targeting basic and clinical scientists, were reviewed. All study designs that included outcome data beyond participant satisfaction were accepted. From an initial 2777 abstracts, 53 papers met the review criteria. Data were extracted by six coders, using the standardized BEME coding sheet, adapted for our use. Two reviewers coded each study and coding differences were resolved through discussion. Data were synthesized using Kirkpatrick's four levels of educational outcomes. Findings were grouped by type of intervention and described according to levels of outcome. In addition, 8 high-quality studies were analysed in a 'focused picture'. RESULTS: The majority of the interventions targeted practicing clinicians. All of the reports focused on teaching improvement and the interventions included workshops, seminar series, short courses, longitudinal programs and 'other interventions'. The study designs included 6 randomized controlled trials and 47 quasi-experimental studies, of which 31 used a pre-test-post-test design. KEY POINTS: Despite methodological limitations, the faculty development literature tends to support the following outcomes: Overall satisfaction with faculty development programs was high. Participants consistently found programs acceptable, useful and relevant to their objectives. Participants reported positive changes in attitudes toward faculty development and teaching. Participants reported increased knowledge of educational principles and gains in teaching skills. Where formal tests of knowledge were used, significant gains were shown. Changes in teaching behavior were consistently reported by participants and were also detected by students. Changes in organizational practice and student learning were not frequently investigated. However, reported changes included greater educational involvement and establishment of collegiate networks. Key features of effective faculty development contributing to effectiveness included the use of experiential learning, provision of feedback, effective peer and colleague relationships, well-designed interventions following principles of teaching and learning, and the use of a diversity of educational methods within single interventions. Methodological issues: More rigorous designs and a greater use of qualitative and mixed methods are needed to capture the complexity of the interventions. Newer methods of performance-based assessment, utilizing diverse data sources, should be explored, and reliable and valid outcome measures should be developed. The maintenance of change over time should also be considered, as should process-oriented studies comparing different faculty development strategies. CONCLUSIONS: Faculty development activities appear highly valued by participants, who also report changes in learning and behavior. Notwithstanding the methodological limitations in the literature, certain program characteristics appear to be consistently associated with effectiveness. Further research to explore these associations and document outcomes, at the individual and organizational level, is required.

Cooperative Behavior↗

The integration of tobacco dependence treatment and tobacco-free standards into residential addictions treatment in New Jersey.

New Jersey was the first state to implement a licensure standard for all residential addiction treatment programs to assess and treat tobacco dependence in the context of entirely tobacco-free facilities (including grounds). A program evaluation of the first year of the policy (2001-2002) assessed the impact on programs, clients, and staff. At 1-year follow-up, all 30 residential programs surveyed provided some tobacco dependence treatment and 50% had tobacco-free grounds. Eighty-five percent of the programs accepted the state's offer to provide free NRT, reaching more than 2,326 clients. Seventy-seven percent of all clients were smokers, and 65% of the smokers reported they wanted to stop or cut down tobacco use. Forty-one percent of the smokers reported that they did not use any tobacco during their entire residential stay. There was no increase in irregular discharges, or reduction in proportion of smokers among those entering residential treatment, compared with prior years. Licensure standards regulation can be an effective mechanism for increasing the quantity and quality of tobacco dependence treatment in residential addictions programs.

Adult↗

Digital imaging methods as an aid in dental identification of human remains.

The physical comparison of known (K) and questioned (Q) evidence samples is an accepted tool in numerous forensic identification disciplines (1). A subset of this process is the use of antemortem and postmortem dental radiographs to identify unidentified human remains. This method has been generally accepted for decades (2). The outcome is performed with a considerable degree of accuracy, due in part to a finite pool of possible candidates for identification derived via the NCIC database, passenger lists, and law enforcement Missing Persons reports. This paper describes a dental identification comparison protocol that incorporated digital imaging technology in this process. The computer was used to create digital exemplars of the K and Q evidence that were spatially and quantitatively compared (3). The digital mode allowed direct metric and morphologic comparison through the aid of a digital camera, desktop computer, monitor, and printer. The well-known computer program Adobe Photoshop 5.0 (4) was used to process the digital information in two forensic cases described in this paper. It is a commercially available digital imaging editing program that is operated on laptop and desktop computers possessing sufficient chip speed and RAM (Pentium II or equivalent and at least 76MB RAM) to open the large-size files generated by high-resolution digital capture devices. This program accepts raster-based image formats (e.g. .JPG, .BMP). Photoshop is noted for its diverse imaging functions, which allow the computer monitor to be used as a comparison microscope when Q and K sample images are tiled side-by-side and/or superimposed. Two and three-dimensional Q and K evidence samples can be individually digitized and then independently resized to allow two-dimensional comparison. The investigator also has the ability to create magnified images (200% to 300%) when the original digital image has been captured at near photoquality resolution (300 dpi). The visual comparison of physical features on the computer monitor permits a large field of view and robust digital control over image quality. Photographic measurement and enhancement features of Adobe Photoshop mimics and in some circumstances surpasses the historic use of conventional photographic manipulation in forensic casework. This paper presents two cases processed via routine forensic odontology identification protocols. These protocols had minimal results due to limitations described in the case histories. The additional application of digital methods proved useful in the ultimate identification of these human remains.

Adolescent↗

[Evaluation of prevention strategies for congenital toxoplasmosis: a critical review of medico-economic studies].

BACKGROUND: Congenital toxoplasmosis (CT) may lead to serious neurological or sensory consequences. A serological screening of women at risk of acquiring toxoplasmosis became mandatory in France, first during the visit before wedding (1978), then during the visit for pregnancy declaration (1985) and at last with a monthly follow-up during pregnancy since 1992. The efficacy and the profitability of the program was never assessed, in spite of the modification of the epidemiological context. However medico-economical studies were conducted in countries in which no prevention program for CT was available to determine the interest of an antenatal screening similar to the French one or of other prevention strategies. METHODS: Eight studies comparing at least two strategies were selected. Methodologies used in those studies were analyzed by two independent readers with the help of a standardized scale. A score was calculated for each study. RESULTS: Each study analyzed suffered from methodological limitations, in particular concerning the estimation of antenatal treatment efficacy, which could lead to invalidate their conclusion. The most reliable studies in regard to methodological guidelines, that is with the higher score, concluded that antenatal screening was not contributive. However, they could not be transposed directly in the present French situation, because of the difference of the epidemiological and economical context. CONCLUSIONS: Given the difficulty to obtain a clear conclusion, it seems necessary to perform a rigorous decision analysis to identify the more effective and acceptable program in terms of human and financial costs for preventing congenital toxoplasmosis.

Cost-Benefit Analysis↗

Community acceptance of residential programs for developmentally disabled persons.

Deinstitutionalization and the ensuing establishment of residence programs for developmentally disabled persons has stimulated both community support and opposition. The present study considers changes in the levels of community acceptance after residence programs are established, sources of program support and opposition, and strategies used to overcome community opposition. The data are based upon responses to a survey of all community residence programs in New York (n = 459). The findings indicate marked and consistent shifts toward the acceptance of established residence programs.

Adult↗

Telephone support for pregnant smokers who want to stop smoking.

This article describes a statewide, proactive telephone peer-support system to help low-income pregnant women stop smoking. From October 1994 to December 2000, 948 pregnant smokers attending the Women, Infants, Children program accepted an offer to receive support by telephone from a woman ex-smoker who called weekly, biweekly, and then monthly to provide guidance, encouragement, and reinforcement for smoking cessation. This free service, funded by the Vermont Department of Health, resulted in 25% self-reported abstinence at last telephone contact when women never reached for telephone support were counted as smokers, and self-reported abstinence during pregnancy of 20% among participants who returned for their postpartum Women, Infants, Children visit. These findings suggest that proactive telephone peer support is a viable way to help pregnant women stop smoking during pregnancy.

Female↗

Value adding through regional coordination of rural placements for all health disciplines: The Broken Hill experience.

OBJECTIVE: To describe the experience of the University of Sydney's Broken Hill Department of Rural Health (BHUDRH) delivering a regional program in far western NSW. DESIGN: Case Study Setting: The Australian Government's University Departments of Rural Health Program, established in 1997, has been responsible for setting up regionally coordinated rural placement programs for students from all health disciplines in each state and territory. RESULTS: Over nine years the BHUDRH has harnessed both academic and administrative resources to achieve greater efficiency in program delivery, increased support for students during their placement, and enhanced educational opportunities that draw on regional issues. The Broken Hill program accepts students from 22 Australian universities and places more students in the region, for longer periods than previously (271 students in 2005 compared with 140 students in 1998). CONCLUSION: Regional coordination, linked to investments in rural-based infrastructure and support systems can provide a sustainable platform from which to provide quality rural placements for students from all health disciplines, while at the same time increasing regional capacity to take students.

Allied Health Occupations↗