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At least 109 records · Page 6Linked to original sources
PubMed2004

[Biochemical and immunological effects of ionizing radiation in radiology staff members].

PURPOSE: This study aimed to investigate the influence of occupational exposures to long term low-dose ionizing radiation on blood biochemistry and immunity levels of the radiology staff. MATERIALS AND METHODS: Fifty-one subjects, aged between 21-57 years (30.06+/-7.02 years), working in the department of radiology were enrolled to this study. Twenty-five subjects (49.1%) were female and 26 (50.9%) were male. Control group consisted of 40 healthy non-smoking subjects aged between 20-60 years (mean 31.5+/-5.75) who had never been exposed to radiation; 19 (47.5%) of these were female and 21 (52.5%) male. Venous blood samples were obtained from the radiology staff and control group and immunological and biochemical analysis of samples were performed. RESULTS: CD4+ T-lymphocyte ratio, and serum total IgA, IgG, IgM and C3, C4 levels were lower in the radiology staff compared to the controls. Serum triglycerides and paraoxonase activities were increased in the radiology staff (p<0.05). CONCLUSION: In radiology workers exposed to long-term low-dose ionizing radiation, levels of the CD4+ T lymphocytes, total immunoglobulins (IgA, IgG, IgM), C3 and C4 levels were lower, while serum trygliceride levels and paraoxonase activities were significantly higher (p<0.05). IgA and IgM levels of smoker radiology workers were significantly lower than non-smoker radiology workers (p<0.05). Since the staff members of department of radiology are vulnerable to the side effects in parallel to the dose of radiation being exposed, we think that in addition to avoiding radiation as much as possible, they should have periodical blood biochemistry and immune function tests.

Adult↗
PubMed1996

[Influence of HPD on immunological functions in patients with nasopharyngeal carcinoma treated by radiotherapy].

Seventy-eight patients with nasopharyngeal carcinoma were equally divided into two groups: 39 patients were treated by HPD plus radiation and 39 patients by radiation alone. Immunological functions were evaluated in each patient before and after radiation. The results showed that (1) in patients treated by RPD and radiation, no statistical difference was observed on immunological functions before and after treatment; (2) in patients treatd by radiation alone, the immunological functions, including OKT3, OKT4, OKT4/OKT8 ratio and lymphocyte transformation, were significantly decreased after treatment. These findings indicate that the immunological functions in patients with nasopharyngeal carcinoma could be protected by HPD during radiotherapy.

Adolescent↗
PubMed1977

Modification of immunological potential by ultraviolet radiation. I. Immune status of short-term UV-irradiated mice.

C3Hf/HeN mice support the progressive growth of most transplanted syngeneic ultraviolet (UV) light-induced tumors following short-term UV exposure whereas nonexposed mice reject these tumors. Because an immunosuppressive role in UV-mediated tumor susceptibility might be suggested by these observations, a comparison of several immunological parameters has been conducted. These include antibody production, proliferation in response to antigenic and mitogenic stimulation, and the generation of cytotoxic effector cells by normal or short-term UV-exposed mice. The results indicate that short-term UV irradiation of mice does not result in any readily detectable alterations of the host's immune system other than the consistent loss of the antitumor response mediating rejection of the transplanted UV-induced tumor.

Animals↗
PubMed1977

Modification of immunological potential by ultraviolet radiation. II. Generation of suppressor cells in short-term UV-irradiated mice.

When normal mice are exposed for short periods to ultraviolet light (UV), they support the progressive growth of transplanted syngeneic UV-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The UV-mediated suppression of the antitumor response can be adoptively transferred to normal syngeneic mice with lymphoid cells derived from short-term UV-irradiated donors. Transfer of the suppressive effect is dosage dependent and also appears to require the presence of viable T lymphocytes. Suppressive activity was observed in both the spleen and thymus of UV-irradiated donors. In the preceding paper we have established that UV irradiation does not cause a general depression of testable immune functions. Collectively these data suggest that short-term UV irradiation of mice leads to an increase in suppressor cell activity, thereby causing an inhibition in the host's ability to respond to an antigenic UV-induced tumor. The possible role of this phenomenon in the mechanism of UV carcinogenesis is discussed.

Animals↗
PubMed2001

Influence of near-ultraviolet radiation on reproductive and immunological development in juvenile male Siberian hamsters.

The aim of this study was to characterize the lenticular ultraviolet transmission of the Siberian hamster (Phodopus sungorus) and to probe the range of near-ultraviolet (UV-A, 315-400 nm) and visible wavelengths (400-760 nm) for modulating the photoperiodic regulation of its reproductive and immune systems. Ocular lenses from adult hamsters were found to transmit UV-A wavelengths at similar levels to visible wavelengths, with a short-wavelength cut-off of 300 nm. Five separate studies compared the responses of juvenile male hamsters to long photoperiods (16 h:8 h L:D), short photoperiods (10 h:14 h L:D) and short photoperiods interrupted by an equal photon pulse of monochromatic light of 320, 340, 360, 500 or 725 nm during the night. The results show that UV-A wavelengths at 320, 340 and 360 nm can regulate both reproductive and immune short-photoperiod responses as effectively as visible monochromatic light at 500 nm. In contrast, long-wavelength visible light at 725 nm did not block the short-photoperiod responses. These results suggest that both wavelengths in the visible spectrum, together with UV-A wavelengths, contribute to hamster photoperiodism in natural habitats.

Animals↗