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At least 109 records · Page 6Linked to original sources
PubMed1975

[Therapy of early symptoms of radiation sickness in dogs using Pyrimetin].

The antiemetic effect of Pyrimetin (V.V.M.I.) in dogs whose whole body had been irradiated with gamma rays with the dose of 500 R, administred per os, intramuscularly, and subcutaneously, immediately before the exposure and after it in the course of the initial symptoms of the radiation sickness was studied. Decreased emesis occurred after per os administration of Pyrimetin immediately before the whole body irradiation of the dogs. After an intramuscular application before the whole body irradiation two dogs vomitted, and in the case of an i.m. administration after the whole body irradiation one dog vomitted. Subcutaneous application of Pyrimetin to dogs before the whole body irradiation and also after it produced only a 30 p.c. therapeutic effect.

Acute Disease↗
PubMed1992

[Selective decontamination of the intestine and total gnotobiologic isolation in treatment of mice with acute radiation sickness].

Comparative study of ciprofloxacin, pefloxacin and amikacin showed that ciprofloxacin and pefloxacin had a selective action on the intestinal microflora of conventional mice. Amikacin induced inhibition not only of the opportunistic bacteria but also of the representatives of the indigenous microflora. The use of the drugs in combination with total gnotobiological isolation in treatment of experimental radiation sickness provided an increase in survival of the irradiated animals, the more so as ciprofloxacin was used.

Acute Disease↗
PubMed1975

[A morphologic analysis of denuding of the villi in the intestinal form of acute radiation sickness].

Light and electron microscopy were applied to the study in sexually mature rats and mice of the areas of the duodenum, jejunum and the ileum 3-4 days after the irradiation in doses of 1000, 1500, 7000 and 15 000 R. Paraffine mucosal sections of the small intestine showed denuding of the stroma of individual villi. However, a study of the thin and semithin epon sections by light microscopy and of the ultrathin ones--by electron microscopy showed the villi to be always covered with enterocytes, whose cytoplasm was overloaded with lipid droplets and almost structureless. Thus, during the enteric form of acute radiation sickness there was no vital denuding of the villi, and the presence of such on paraffine sections served as the result of inadequate treatment of the material.

Animals↗