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Results for “RETROLENTAL FIBROPLASIA”

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PubMed1983

Central retinal arteries in hyperoxemia, and a possible role of fundusscopy in prevention of retrolental fibroplasia (retinopathia praematurorum).

Width and tortuosity of the central retinal arteries have been measured on fundus photographs of 9 full-term newborns under intensive care taken at least once in normoxemia and once in inadvertent hyperoxemia. In agreement with previous investigators no correlation was found between the actual paO2 and width of the arterioles. This is newly explained as a modification of the effect of paO2 on the vessel through acute asphyxia and adaptational phenomena. In opposition to the commonly accepted view on prevention of retrolental fibroplasia it is felt that the use of fundusscopy during intensive care should be reconsidered.

Asphyxia Neonatorum↗

PubMed1980

Angioma-like mass in a patient with retrolental fibroplasia.

A 13-year-old boy had mild vitreous hemorrhage in the left eye, and a red angioma-like epiretinal mass in the equatorial zone of the temporal fundus. The retina anterior to the mass was nonvascularized, and similar nonvascularization of the pre-equatorial retina was present in the temporal quadrants of the fellow eye. Fluorescein angiography showed intraretinal neovascularization along the margin of the perfused and nonperfused retina and leakage from portions of the angioma-like mass, suggesting that it was composed of neovascular tissue and adjacent hemorrhage. The patient had been a premature infant, with a birth weight of 1,092 g, supporting the presumptive diagnosis of previously asymptomatic retrolental fibroplasia. Photocoagulation was successful in obliterating the neovascular tissue.

Adolescent↗

PubMed1975

The role of oxygen in retrolental fibroplasia.

The effects of oxygen in the immature or incompletely vascularized retina are conveniently divided into an initial vasoconstrictive and obliterative stage and a secondary vasoproliferative response that occurs after removal of the subject from an enriched oxygen environment. Vasoproliferation starts at the zone of perfused and nonperfused retina. The incompletely vascularized retina is uniquely responsive to these oxygen-induced changes. After vascularization is complete and the retinal vessels reach the ora, the susceptibility to hyperoxia disappears. The vessels in the temporal periphery of the retina have a peculiar susceptibility to the primary and secondary effects of hyperoxia on the immature retina. Ophthalmoscopic examination of the temporal periphery therefore should always be done carefully in the premature infant or in older individuals giving a history of prematurity. The indirect ophthalmoscope provides the most satisfactory instrument for examination. The incidence of retrolental fibroplasia has been greatly reduced following the incrimination of oxygen as its principal cause. Further studies are still required to determine precise blood oxygen levels that are safe for the premature retina and to discover other factors that may play a role in the pathogenesis or RLF.

Animals↗

PubMed1957