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PubMed1997

The physical and chemical nature of technegas.

UNLABELLED: Technegas, the discrete radio-aerosol particle, containing 99mTc has been investigated, and the chemical evolution and physical properties of the particle demonstrated. METHODS: A commercial technegas generator was used to produce aerosols according to standard clinical procedures. The aerosols were collected by electrostatic precipitation and examined with transition electron microscopy (TEM), scanning electron microscopy (SEM) and force microscopy. The chemical evolution was examined by x-ray techniques and thermogravimetric analysis. RESULTS: The active particle was identified as hexagonal platelets of metallic technetium contained within a thin layer of graphitic carbon. This composite structure is discussed in light of the metal particle behaving as a template for the carbon capsule. The average size of the observed hexagonal platelets, 30-60 nm, was only weakly dependent on the concentration of technetium in the crucible. CONCLUSION: The mechanism for the formation of the technegas pancreas has been developed and the particles involved characterized. It appears that the use of other metals also leads to the formation of similar materials.

Aerosols↗
PubMed1983

Impurities of 99mTc-generators.

The impurities present after use in 99Mo- 99mTc-generators produced by four different manufacturers were investigated by means of the energy spectrum and half-life measurements. The generators produced with fission contained only a few impurities, and the half-lives of their nuclides were relatively short. The only generator manufactured using neutron bombardment contained several nuclides whose half-lives were in a range of a few months, but also a 60Co nuclide whose long half-life may give rise to difficulties in destroying the generator.

Humans↗
PubMed1983

Effect of milking efficiency on 99Tc content of 99mTc derived from 99mTc generators.

Calculation was made of the effect of milking efficiency on the 99Tc content of 99mTc derived from 99mTc-generators. Reduced milking efficiency was shown to lead to an increase in the 99Tc/99mTc ratio. Levels of 99Tc were determined in samples from both column and solvent extraction generators using a HPLC procedure. It is recommended that producers of 99mTc from solvent extraction generators should ensure that complete generator milking is performed daily.

Methods↗
PubMed1982

Development of a reliable Hg-195m--Au-195m generator for the production of Au-195m, a short-lived nuclide for vascular imaging.

A new mercury-195m (T1/2: 41 hr) leads to gold-195m (T1/2: 30.6 sec) generator suitable for first-pass as well as steady-state radionuclide angiography studies has been developed. The distribution coefficients, Kd, for mercury (Hg-195m) and gold (Au-196), experimentally evaluated on chelating resin Chelex 100, showed this resin to be suitable as the column packing. Mercury-195m in a Trisma buffer solution at pH 7.40 was loaded on a chelating resin Chelex 100 column, together with gold carrier. Au-195m was eluted with an aqueous solution of 5% glucose in a 0.01M Trisma buffer at pH 7.70 (25 degrees C). Chemical assessment of the eluate has ensured that the eluted carrier-free gold is by no means colloidal: 80% is found in an ionic form, 20% as an uncharged species. Safe clinical use for routine diagnosis in humans is possible.

Gold Radioisotopes↗
PubMed1987

[Determination of residual activities in 99mTc generators and 81mKr generators].

The residual activities present in spent 99Mo-99mTc generators and 81Rb-81mKr generators were determined from a view point of the disposal of radiopharmaceuticals. The results showed that seven kinds of residual nuclides such as 95Zr-95Nb, 103Ru, 90Sr, etc. were found in 99mTc generators with maximum level of 740 Bq/3.7 GBq (0.02 muCi/100 mCi) at one year after the reference date. In 81mKr generators one year old, six nuclides such as 57Co, 83Rb, 84Rb and others remained and these activities were less than 3.7 kBq/370 MBq (0.1 muCi/10 mCi). On the basis of these data, the disposal of 99mTc generators and 81mKr generators is discussed.

Humans↗