Pest-control measures.
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Coumestrol, a compound produced by various legumes which exerts estrogen-like activity in animals, and diethylstilbestrol (DES) were studied as chemical agents for controlling reproduction in mice. Female mice were fed control diets or diets containing 100 ppm coumestrol for eight days. Female mice were exposed to males and reproductive tracts examined 14 days later. Litter size was not affected by 100 ppm dietary coumestrol but feed consumption was reduced 17%. Similar trials were conducted with mice fed 1 ppm DES. Vaginal plugs were present in 50% of the females fed 1 ppm DES, but no fetal pups were present. Feed intake was reduced 37% by the DES. Levels of 0, .1, .25, .50, .75 and 1.0 ppm DES were compared in two strains of mice, Swiss and ICR. Reproduction in both strains was totally inhibited by all DES treatments. The use of DES to control rodent populations warrants further investigation.
Two groups of rhesus macaques (Macaca mulatta) housed in rodent-controlled outdoor corrals were inoculated with two different encephalomyocarditis virus (EMCV) vaccines. One group (n = 45) received a vaccine made from an inactivated field isolate of virus cultured during an outbreak at a zoo in Florida. This vaccine produced fourfold increases in the titers of 28 animals (62%); the increases persisted for at least 18 months (last test) after a single injection of the vaccine. The other group (n = 51) received a vaccine made from an inactivated porcine field strain of the virus. This vaccine did not produce titers in any of the vaccinees.
An outbreak of chlamydiosis was investigated in workers at a duck farm and processing plant during winter 1989. Chlamydia psittaci was isolated from ducks, but there was little evidence of clinical chlamydiosis in the ducks. Serological tests showed that 76% of workers had been exposed to infection, 12% recently, 16% had not been exposed and 8% had inconclusive test results. There was a strong association (P < 0.05) between years of employment and exposure to infection. Infection appeared to be contracted during the first year of employment. Measures were implemented to reduce shed contamination and control rodents and wild birds. At the same time, ducks were medicated, the processing plant was modified, work practices were altered and workers were advised about chlamydiosis to reduce the risk of human infection.
Lassa fever is a severe febrile illness of man, first recognized in West Africa in 1969. During an epidemic in Sierra Leone, Lassa virus was isolated for the first time from wild rodents of Mastomys natalensis. A high prevalence of infected Mastomys was found in houses occupied by patients with Lassa fever. The data presented provide the first demonstration of an extra-human cycle of Lassa virus transmission and suggest that rodent control may be an effective method of limiting the disease.
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Measures to control rodents have resulted in a decreased incidence of murine typhus, but it is also likely that it is being underdiagnosed because many medical practitioners do not include it in their differential diagnosis of pyrexia of unknown origin. Four recent cases are described, and historical aspects of this disease in Australia are presented.
Strychnine poisoning was diagnosed in free-flying mallards (Anas platyrhynchos) and a ring-billed gull (Larus delawarensis) found dead on a pond in a zoo. The probable source of toxin was improperly applied strychnine-treated grain used for control of rodents on adjacent farm land. Ingesta of the birds contained 19.7-85.1 mg/kg of strychnine.
Apathy and ignorance about pest infestation and the health risks involved are the subject of an article by Norman Southam, who discusses the use of pesticides and measures to control and eradicate many pests which thrive in many hospitals today.
Five cases of murine typhus occurring on southwestern Kauai in 1998 are described, following an investigation by the Department of Health. Two cases also had concurrent leptospirosis. Recent habitat changes of peridomestic animals and their fleas may have increased the risk for developing murine typhus. Increased suspicion of typhus by island physicians and more aggressive rodent control activities are recommended.
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In East Germany the same serovar, Leptospira mozdok, of the Pomona serogroup is found in cattle as well as in swine populations (Zieris 1989). Nowadays cases of bovine leptospirosis caused by infection with L. pomona have no significance. There are marked epizoological differences between infection with L. mozdok and L. pomona. The main source of infection with L. mozdok for cattle is the black striped field mouse (Apodemus agrarius). Secondary homonomous transmission occurs among the cattle. The clinical course of both infections is the same--including peracute, acute and chronic forms. Important prophylactic measures are effective rodent control and optimising hygiene conditions both in housing and on pasture. Veterinarians in abattoirs must consider leptospirosis in the differential diagnosis in cases with icteric signs, especially when the meat is derived from emergency slaughter.
Three flocks of Japanese quail, approximately 75,000 birds each, experienced acute high mortality beginning at 24 to 28 days of age. Gross lesions were absent or were composed of either multifocal small pale areas on livers and spleens or lungs slightly darker in color than normal. Histopathology revealed multifocal splenic and hepatic necrosis and interstitial pneumonia. Pasteurella multocida, serotype 3,4, was isolated from affected tissues. The quail were successfully treated with chlortetracycline, and the organism was apparently eliminated from the premises by thorough cleaning, disinfection, and insect and rodent control. Experimental studies showed Japanese quail to be highly susceptible to disease caused by the P. multocida isolated from the affected flocks.
An active natural focus of icterohemorrhagic leptospirosis has been detected in the area of fish-breeding ponds in Rostov Province, where the intensive epizootic among the population of Norway rats is observed the whole year round (574 animals have been examined, 56 cultures have been isolated). The epizootic process reaches its highest intensity in autumn (the proportion of infected animals exceeds 50%). This natural focus in the area of fish-breeding ponds is epidemiologically dangerous. The limitation of its infectious potential is possible by means of poisoned baits.
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