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At least 109 records · Page 6Linked to original sources
PubMed1989

Impaired non-specific delayed cutaneous hypersensitivity in bird fancier's lung.

The relation between non-specific delayed cutaneous hypersensitivity and bird fancier's lung was investigated in 13 patients with the disorder. They were compared with 50 subjects who had no reason to have decreased non-specific delayed cutaneous hypersensitivity (control group) and 34 patients with pulmonary sarcoidosis. In addition, 13 patients with bird fancier's lung (11 of the original group) were tested at least one year after avoiding exposure to the causal antigen. Five antigens (candidine, staphylococcal toxoid, tuberculin purified protein derivative, trichophyton, and streptokinase-streptodornase) were injected intradermally (0.1 ml) and the mean weal diameter was measured at 48 hours. The mean weal size was significantly less in the subjects with bird fancier's lung at the time of diagnosis than in the control group (2.23 v 5.66 mm) but did not differ significantly from that of the subjects with sarcoidosis (2.80 mm) or from that of the bird fanciers with no exposure to the causal antigen for one year (2.75 mm). The impairment of non-specific delayed cutaneous hypersensitivity in patients with bird fancier's lung appears to be quantitatively similar to that occurring in sarcoidosis.

Adult↗
PubMedDate not supplied

[Activation of Langat virus infection in mice under the influence of Licopid].

The impact of Licopid and purified staphylococcal toxoid on the development of neurovirus infection caused by Langat virus was experimentally studied with mice as a model. The prophylactic (prior to infection) use of licopid was found to activate the infection. In the population of macrophages of different localization the proportion of cells with virus penetration and proliferation increased 5- to 11-fold under the influence of Licopid. The results obtain give evidence to conclude that immunomodulators should be used with caution as they show not only positive effects.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1991

[Delayed nonspecific cutaneous hypersensitivity in extrinsic allergic alveolitis and idiopathic pulmonary fibrosis].

BACKGROUND: A study of delayed nonspecific cutaneous hypersensitivity in extrinsic allergic alveolitis and in idiopathic pulmonary fibrosis. METHODS: 13 patients with extrinsic allergic alveolitis, 10 with idiopathic pulmonary fibrosis, 34 with sarcoidosis and a control group of 110 subjects without respiratory disease or apparent defects in cell immunity were evaluated. The skin tests of delayed hypersensitivity were carried out with five antigenic extracts (candidin, staphylococcal toxoid, tuberculin-PPD, trichophyllin, streptokinase-streptodornase). The reactions were read after 48 hours. Delayed nonspecific cutaneous hypersensitivity was globally calculated, both quantitatively (sum of the mean diameters) and quantitatively (overall average of positive reactions). RESULTS: No significant differences were found between the group of patients with idiopathic pulmonary fibrosis and the control group, nor between those with extrinsic allergic alveolitis and those with sarcoidosis. However, differences were found between the control group and the patients with extrinsic allergic alveolitis, both in the quantitative and the qualitative analysis. CONCLUSIONS: Delayed nonspecific cutaneous hypersensitivity in extrinsic allergic alveolitis is depressed in a similar way as in sarcoidosis, whereas it appears to be preserved in idiopathic pulmonary fibrosis. Therefore, extrinsic allergic alveolitis should be considered as another cause of reduction of delayed nonspecific cutaneous hypersensitivity as it is the case with sarcoidosis.

Adult↗
PubMed1986

[Effectiveness of various programs of immunocorrective therapy in chronic infectious-inflammatory diseases].

An immunological study of patients with chronic pneumonia, osteomyelitis, pyoderma and candidosis showed various changes in cellular immunity values within each nosological group of examined patients. The efficacy of levamisole therapy was higher in the group of patients where an increase in the number of E-rosette forming cells and NBT-test values by more than 10% was noted in vitro in the presence of 10 micrograms/ml of levamisole as opposed to patients with a less increase in these values or their decrease. Nonspecific immunotherapy (levamisole, prodigiosan) following specific immunotherapy (staphylococcal anatoxins and antiphagin or autovaccines) proved to be more effective in the treatment of patients with chronic infectious inflammatory diseases than the reverse sequence of immunotherapy courses.

Adjuvants, Immunologic↗