The Effect of Penicillin on Experimental Streptococcus, Pneumococcus and Staphylococcus Infections of the Egg Embryo.
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UP to 30% of those who undergo surgery potentially develop a surgical site infection depending on the procedure performed. Infection increases the risk of further complications, lengthens hospital stays and increases management costs. A significant proportion of surgical site infections are caused by Staphyloccoccus spp. and prior nasal carriage is a risk factor for post surgical infection.
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The authors discuss some problems concerning the use of models in biomedical research and particular animal models of staphylococcal infections simple, reproducible and similar to the corresponding human diseases. Two models of staphylococcal infections are examined in particular: experimental endocarditis and osteomyelitis, considering their characteristics and reliability in relation to the corresponding human diseases.
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The combined preparation consisting of the antigenic complexes of staphylococci (1 part), Proteus (1 part) and P. aeruginosa parts) was capable of protecting mice from infection with staphylococci, Proteus and P. aeruginosa and prolonging the survival time of rabbits under the conditions of the development of staphylococcal sepsis. The staphylococcal component of the combined preparation possessed adjuvant activity, increasing the immunogenicity of Proteus antigen. The combined vaccine enhanced a short-time increase in the nonspecific resistance of the animals. The moderate toxicity of the preparation permits making multiple injections of the preparation to mice without inhibiting the weight gain of the animals.
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