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PubMed1990

Sebaceous lesions of salivary glands and oral cavity.

Sebaceous differentiation in the oral mucosa and major salivary duct epithelium is an expected normal finding in humans. These usually asymptomatic and incidental collections of sebaceous cells can also be found in intimate or close relationship with definable classes of salivary gland neoplasms, or as sebaceous neoplasms of salivary glands. The neoplasms are uncommon and are classified as sebaceous lymphadenoma, sebaceous adenoma, and sebaceous carcinoma. The two adenomas have a low recurrence potential; the carcinomas have a biologic behavior like that of ocular sebaceous carcinomas.

Age Factors↗
PubMed2002

Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma.

AIMS: Regulation of cell cycle progression is a fundamental control process, linked to cellular differentiation and apoptosis in normal tissues. p21(WAF1) is a nuclear protein that regulates cell cycle progression. p21(WAF1) can be transcriptionally upregulated by p53, but may be activated independently of p53-for example, during terminal differentiation. Loss of topological control of p21(WAF1) expression is an early feature of malignancy in the colorectal system. Similar to the colonic mucosa, sebaceous glands contain cells that are constantly going through a process of cell division, differentiation, and cell death. This study investigated the expression of p53, p21(WAF1), and the proliferation marker Ki67 in normal sebaceous glands, sebaceous adenoma, sebaceoma, and sebaceous carcinoma. METHODS: Serial sections were stained with monoclonal antibodies to p21(WAF1), p53, and Ki67 (MIB1) using standard immunohistochemical techniques. RESULTS: In normal sebaceous glands, p21(WAF1) positive cells were only seen within the differentiating compartment, which was spatially distinct from the cycling peripheral Ki67 positive cells. In sebaceous adenoma and sebaceoma, topological control was maintained, with the distribution of markers being similar to that seen in normal sebaceous glands. Loss of topological control of markers of cellular control was seen in sebaceous carcinoma only. This contrasts with colonic tumours, in which loss of p21 compartmentalisation is seen in adenomas at an early stage of tumour progression. CONCLUSION: This work confirms the hypothesis that the dysregulation of cell cycle progression is an important process in the development of malignancy within sebaceous glands, although loss of topological control was seen only in sebaceous carcinoma.

Adenocarcinoma, Sebaceous↗
PubMed2001

[Sebaceous gland carcinoma of the neck].

Extraocular sebaceous carcinoma is a rare skin neoplasm that resembles clinically pyogenic granuloma, hemangioma or squamous cell cancer. The clinical and histological findings are described. The differential diagnosis of common tumors of the face should include this rare malignancy.

Biopsy↗
PubMed1984

Sebaceous gland tumors and systemic disease: a clinicopathologic analysis.

The association of sebaceous gland neoplasms with visceral carcinomas, first described by Muir and Torre, has become widely recognized. The purpose of our study was to determine the prevalence of malignancy, other associated diseases, and familial carcinoma in patients who had one or more cutaneous lesions within the spectrum of sebaceous adenoma, epithelioma, or carcinoma. Our histopathology files contained tissue from 59 such cases. Overlap between the categories was common, often precluding precise histologic classification. Of the 59 patients, 25 (42%) had one or more primary visceral malignancies. These totaled at least 49, of which 25 were colonic, 9 urogenital, 5 hematologic, 4 breast, and 6 miscellaneous. Fifteen patients (25%) had colonic polyps, most often multiple; and at least one primary carcinoma of the colon appeared in 10 of these, initially or later. Other less common findings included uterine fibroids, thyroid adenomas, and benign renal cysts. A family history of carcinoma was found in 72% of cases with visceral malignancy, most often of the colon and stomach. We conclude that sebaceous neoplasms form a histologic continuum, and strong associations with colonic polyps, internal malignancy, and a family history of carcinoma are apparent.

Adenocarcinoma↗
PubMed1979

Sebaceous gland differentiation. I. Separation, morphology and lipogenesis of isolated cells from the mouse preputial gland tumor.

Single cell suspensions have been prepared, by enzyme digestion, from the mouse preputial gland tumor and separated by flotation centrifugation into populations of different buoyant densities. These populations of cells have been shown by morphological, chemical and biochemical criteria to be in different stages of maturation. Some properties of the separated cells are described.

Animals↗