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PubMed1990

[Immunological status of patients with recurrent herpes simplex infections. In vitro effect of thymopoietin and splenin-derived and partially modified peptides on peripheral blood lymphocytes in comparison to a thymus extract].

Immunological studies on 20 patients with frequently recurrent Herpes simplex labialis were performed. Disorders of the cell-mediated immunity were often observed which do not only occur during the relapses. The number of T cells and their function were especially reduced. On the other hand there were no alterations of the CD4/CD8 ratio and the suppressor-activity. In vitro studies with peptides of thymopoietin and splenin justify the assumption that these peptides have therapeutic effects in recurrent herpes simplex infections.

Amino Acid Sequence↗
PubMedDate not supplied

[Effect of thymus extract TFX (Polfa) on hemoglobin level and peripheral blood erythrocyte count].

Calf thymus preparation (TFX-Polfa) was administered + to 25 patients with classic rheumatoid arthritis in the II and III phase of the disease. Only patients not tolerating gold or D-penicillamine because of allergy or other complications, were included into the study. TFX was administered in a daily dose of 10 mg TFX protein i.m. for 60 consecutive days, followed by the treatment in outpatient clinic for successive++ 10 months. Statistically significant increase in the hemoglobin concentration and erythrocyte counts was produced by both a 2-month intensive treatment and a 12-month of therapy with TFX.

Anti-Inflammatory Agents↗