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PubMed2005

[Case report: cutaneous tuberculosis and tuberculous osteomyelitis].

In this report, a 27 years old male patient diagnosed to have skin and bone tuberculosis (TB) has been presented. The patient admitted to the hospital with the complaints of fever, weight loss and night sweats. Patient's history revealed that following a trauma a skin lesion in the right ankle was developed and this was followed by the development of many lesions in different parts of the body. The lesions persisted despite the use of various antibiotics since a year. It has been recorded that his father has already been receiving anti-tuberculosis treatment. Osteomyelitis was detected in the distal part of right tibia by computerized tomography, and Mycobacterium tuberculosis was isolated from the specimens of skin lesion. The patient was immunocompetent, and there was no pulmonary involvement. Isoniazid (INAH), rifampin (RIF), ethambutol and morphozinamid therapy has been started and completed to 12 months with INAH and RIF. In the post-treatment follow-up of patient for one year, no relapse was detected. As a result, tuberculosis should be considered in patients with persistent skin lesions especially in endemic countries.

Adult↗
PubMed1990

[Two cases of cutaneous tuberculosis].

Two cases of skin tuberculosis are reported. In one of them diagnostic difficulties were present, in the other pulmonary tuberculosis was associated with two forms of skin tuberculosis. Spinocellular carcinoma developed in a recently developed scar after invasive skin tuberculosis.

Adult↗
PubMed1998

[A case of cutaneous tuberculosis associated with steroid therapy for mixed connective tissue disease].

Patients receiving immunosuppressive therapy, such as adrenocorticosteroids, are high risk groups of tuberculosis. We report a case of cutaneous tuberculosis associated with steroid therapy for mixed connective tissue disease. A 63-year-old female was hospitalized after 6 months' treatment with prednisolone for connective tissue disease and bilateral abnormal shadows were revealed on her chest X-ray films. As her sputum smear was positive for acid-fast bacilli, the patient was transferred to our hospital for isolation and treatment. After three months' treatment with INH, RFP and EB, she complained the swelling of her left palm, left arm, and right leg, and skin puncture was performed. As smears of fluid aspirated from the swelling showed acid-fast bacilli, and fluid PCR tests showed positive for M. tuberculosis, she was diagnosed as cutaneous tuberculosis (scrofuloderma). In spite of administration of antituberculous agents, the swelling showed little improvement. Therefore, the dose of prednisolone was reduced and cutaneous lesions were resected by surgery. High risk of tuberculosis should be considered when a patient administered immunosuppressive drugs, such as adrenocorticosteroids.

Anti-Inflammatory Agents↗
PubMed2005

Cutaneous tuberculosis: a three year prospective study.

OBJECTIVE: To study the pattern of clinical presentation of cutaneous tuberculosis. METHODS: All patients with clinical suspicion of cutaneous tuberculosis, visiting outpatient department of Dermatology Unit, Jinnah Postgraduate Medical Centre, Karachi were included in this study. Total number of the patients enrolled were 74. The lesions were then classified into four clinical types viz: lupus vulgaris, scrofuloderma, tuberculids and tuberculosis verricosa cutis. RESULTS: A total of 0.1% patients visiting out patient department had cutaneous tuberculosis. Scrofuloderma was the commonest form seen in 48 (64.9%) patients, followed by lupus vulgaris in 16 (21.5%), tuberculosis verrucosa cutis in 6 (8.1%) and tuberculids 4(5.6 %). The presence of regional lymphadenopathy had correlation with the disseminated disease. CONCLUSION: There is an increasing trend of cutaneous Tuberculosis over the years. Scrofuloderma was the most common clinical presentation, followed by lupus vulgaris, tuberculosis verrucsa cutis and tuberculids. Tuberculous gumma was not seen in any patient.

Adolescent↗