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At least 109 records · Page 6Linked to original sources
PubMed1988

Smooth muscle neoplasms of the uterus other than ordinary leiomyoma. A study of 46 cases, with emphasis on diagnostic criteria and prognostic factors.

Thirty-seven cases of uterine leiomyosarcoma are presented, along with nine cases of leiomyoma variants from which they were distinguished. All patients were followed for a minimum of 10 years. In cases with nuclear pleomorphism, leiomyosarcoma was diagnosed when there were five or more mitotic figures in ten consecutive high-power (X400) fields in the most active area of the tumor, and also when there were fewer mitotic figures but extensive tumor necrosis (there was only one leiomyosarcoma without nuclear pleomorphism, and it had more than 20 mitotic figures in ten high-power fields). Tumor size was the major prognostic factor in the leiomyosarcoma group; five of eight patients with neoplasms measuring less than 5 cm in maximum dimension survived, whereas no patient with a larger tumor did so. Other pathologic and clinical variables, including mitotic rate, tumor necrosis, degree of nuclear pleomorphism, vascular invasion, and patient age, had no significant relationship to survival or tumor behavior in leiomyosarcoma when tumor size was taken into account. The nine cases of leiomyoma variants consisted of three atypical leiomyomas (which had nuclear pleomorphism, one or no mitotic figures per ten high-power fields, and no necrosis), two plexiform leiomyomas, two cases of peritoneal leiomyomatosis, one palisaded leiomyoma, and one case of intravenous leiomyomatosis; all of these patients were tumor-free on follow-up.

Adult↗
PubMed1988

[Mortality of malignant neoplasms of the uterus. An epidemiologic study].

In the Federal Republic in 1952 5204 cases of death by cancer of the uterus were officially reported, i.e. 20.2 per 100,000. Up to 1985, after an increase to 1967, the figures constantly have decreased to 4706 and 14.8 respectively. Of all cancer deaths in 1952 11.1 percent were that of the uterus, in 1985 only 5.8 percent. The evaluation is hampered by the existence of different statistical groups, particularly by that for cases with unspecified site. In 1985 this groups still comprised 33.7 percent of all registered cases of death by uterine cancer. But irrespectively of this special problem mortality of cancer of the cervix as well as of the corpus uteri has declined, starting already before 1971, the year in which the official cancer screening programme became effective. And for cancer of the corpus uteri the impact of screening is negligible thus the decline cannot be alone the result of screening. The decline in mortality was most impressive in younger women up to 49 years, not in the older age groups and the maximum was observed now above 90 years. Thus participation in the screening programme by elder women should be intensified. Even allowance for hysterectomies cannot influence seriously the favourable trend for mortality of cancer of the uterus, but the rank order for all female malignancies is still no. 6, after breast, colon, stomach, all unspecified sites, ovar. If there is no cancer registry with exact figures for incidence this can be estimated being about three times higher than mortality.

Adult↗
PubMed1997

Smooth muscle neoplasms of the uterus.

Recent investigations, using DNA technology, of the molecular biology of smooth muscle tumours of the uterus have confirmed their monoclonality and have strengthened the view that oestrogen and oestrogen receptors play a major role in the pathogenesis of fibromyomata. In addition, increasing evidence suggests that progesterone, insulin-like growth factors, epidermal growth factors and other proteins are also involved. The mechanisms whereby gonadotrophin-releasing hormone agonists cause shrinkage of fibromyomata remain controversial but both vascular changes and cellular atrophy appear to play a role. A shift of emphasis in the study of fibromyomata has resulted from the demonstration that the myometrium adjacent to fibromyomata is not normal and shows some similarities to the tumours themselves.

Cytogenetics↗
PubMed1982

[Malignant neoplasms of the uterus in the capital city of East Germany, Berlin, in the period from 1975 to 1979].

Some important data characterizing the situation in endometrial cancer control during the period from 1975 to 1979 in the capital of the German Democratic Republic, Berlin were analyzed. The analysis demonstrates a further increase of the standardized incidence rate to 23.2/100,000. The increase is strictly limited to the age-groups between 65 and 80. The mortality rate decreased to 7.3 100,000. Further progress in endometrial cancer control can be demonstrated by an increase of cases detected in stage I (68%) and a significant increase of the 5-Year-Relative-Survival-Rate (1965 to 1968: 69%/1975-76: 77%). During the period analysed there was an marked increase of patients treated by radical surgery or radical surgery plus radiotherapy and a decline of patients treated by radiotherapy alone. Some conclusions are drawn concerning the further improvement of prevention, early detection and treatment of endometrial cancer.

Adult↗
PubMed1992

Endometrial stromal neoplasms of the uterus. A clinicopathologic study.

A clinicopathologic study of uterine endometrial stromal tumors (EST) has been performed with special emphasis on histologic and immunohistochemical differential criteria and prognostic factors. The material comprised three stromal nodules (SN), twelve low grade stromal sarcomas (LGESS) and five high grade stromal sarcomas (HGESS). Previously unreported endolymphatic growth was found within one SN. EST showed an association of mitotic index (IM) with atypia, degree of stromal differentiation, additional non-stromal differentiation and venous invasion. IM was the best criterion in the differential diagnosis of LGESS and HGESS and the most significant histologic prognosticator. The present study shows that a histologic grade of stromal sarcoma was a more significant prognostic factor than pTNM stage. The results suggested that clinicopathologic classification of EST could be supplemented by including the following subgroups: a) SN--without intravascular growth, and potentially malignant SN--with endolymphatic growth within the tumor; b) LGESS with IM < 2 and no atypia, and LGESS with 2 > IM < 10 and mild atypia; c) HGESS with 10 > IM < 20 and moderate atypia, and HGESS with IM > 20 and marked atypia. Contrary to common view these observations indicate that the distinction of some SN and LGESS from stromal hyperplasia is possible in an endometrial curretage material.

Adult↗
PubMed1981

Mixed mesenchymal tumours of the mouse uterus.

Mixed mesenchymal neoplasms of the uterus of 8 mice had either leiomyosarcoma or fibrosarcoma components. 6 had osteoid and 2 had both vacuolated and undifferentiated neoplastic cells. The putative chondrosarcoma component varied from a poorly-differentiated appearance (sheet-like masses of cells) to a myxoid appearance with giant cells and cells with cytoplasmic vacuoles. 1 tumour contained well-differentiated bone that was located within the primary and just beneath the splenic capsule. In another tumour composed of osteosarcoma, chondrosarcoma and fibrosarcoma, the latter component had invaded the wall of the rectum.

Animals↗