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Results for “Uncertainty score”

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PubMed2005

[Influencing factors of depression in women with endometriosis].

PURPOSE: The purpose of this study was to understand depression in women with endometriosis and to identify the factors influencing depression. METHOD: The instruments used were the Beck Depression Inventory for depression, Lemaire Scale for endometriosis syndrome, Mishel Uncertainty in Illness Scale-Community form (MUIS-C), the Rosenberg Self-esteem Scale, and Quality of Life (Endometriosis Health Profile Questionnaire; EHP-5) by Jones et al. The Subjects of Study were 118 outpatients diagnosed with endometriosis from 7 hospitals in Busan City and Kyungsangnam-do. Data was collected from Aug 1, 2004 to Jan 31, 2005. For statistical analysis of collected data, frequency analysis, analysis of variance, and stepwise multiple regression analysis were used with the SPSS statistical program. RESULT: The general characteristic showing a statistically significant difference in depression in the women with endometriosis was marital status. The score of the depression showed a significantly positive correlation with the score of endometriosis TSD(r= .464, p= .000), uncertainty(r= .393, p= .000), and quality of life(r= .543, p= .000). Depression showed a significantly negative correlation with the score of self esteem(r= - .557, p= .000). Stepwise multiple regression analysis revealed that the most powerful predictor of depression in the women with endometriosis was self-esteem (R2=0.311). A combination of self esteem, quality of life, and total symptom distress accounted for 50.0% of the variance in depression in women with endometriosis. CONCLUSION: The influencing factor on depression in women with endometriosis was self- esteem, quality of life, and endometriosis TSD. Further studies need to be done to identify methods of overcoming and the presentation of depression in endometriosis.

Adult↗

PubMed1989

Diagnosis of birth asphyxia on the basis of fetal pH, Apgar score, and newborn cerebral dysfunction.

Imprecise diagnosis of birth asphyxia coupled with uncertainties about causal factors for neurologic abnormalities in the newborn have greatly fueled the current litigation crisis in obstetrics. Our goal was to more precisely define birth asphyxia based on fetal condition as measured by umbilical artery blood pH, Apgar scores, and neurologic condition of newborns. We selected for study 2738 patients with singleton pregnancies with cephalic presentations who were delivered of infants at term to avoid complications such as prematurity, which may affect infant outcome independent of birth condition. The basis for study of these particular patients were defined criteria for high risk and an indicated arterial cord pH value. A total of five infants demonstrated cerebral dysfunction as evidenced by seizures during the neonatal period. Infection was linked to seizures in three of these infants; one infant had neonatal asphyxia and only one infant's clinical course could be attributed solely to birth events (uterine rupture). Stratification of umbilical artery blood pH values, Apgar scores, and combinations of these dependent variables in relation to newborn clinical outcomes revealed that infants must be severely depressed at delivery before birth asphyxia can be reliably diagnosed. Such depression includes Apgar scores less than or equal to 3 at 1 and 5 minutes plus umbilical artery pH values less than 7.00.

Acid-Base Equilibrium↗

PubMedDate not supplied

Gender differences in psychosocial risk factors for psychological distress among immigrants.

The reasons for a greater prevalence of psychological distress among women than men remain unknown. We sought to test two hypotheses that gender operates either as (1) a moderator or (2) a mediator between psychosocial risk factors and experienced distress. A cross-sectional community survey of 1,062 adult Russian-born Jewish immigrants to Israel was conducted. The Demographic Psychosocial Inventory (DPSI) and the Talbieh Brief Distress Inventory (TBDI) were used to measure the parameters of interest. Univariate and multivariate analyses were used to test the moderation versus mediational hypotheses of gender in the stress-distress relationship. The aggregate levels of psychological distress and depression, anxiety, and obsessive symptoms were significantly higher for women than for men. Five sources of distress were more likely to be reported by women: family problems, inappropriate climatic conditions, anxiety about the future, poor health status, and uncertainty in the present life situation. Men scored higher on three stress-protective factors: the number of reasons for immigration, commitment to the host country, and job adequacy. Results of multiple regression and multivariate analysis of variance (MANOVA) supported the mediation hypothesis that gender differences in psychological distress stem from women's greater exposure to specific psychosocial stressors. Our findings demonstrate the validity of gender as an important mediating mechanism underlying the differential perception of risk factors for the development of psychological distress.

Adaptation, Psychological↗

PubMed1998

Reliance on high technology among senior medical students.

To gain a better understanding of senior medical students who perceive high-technology medicine as the desirable form of medical practice, we developed and evaluated a structural equation model. Intolerance to clinical uncertainty, Machiavellianism, and authoritarianism characterized students who scored higher on reliance on high-technology medicine. High scorers also tended to have a negative orientation toward patients' psychological problems and were unlikely to choose careers in primary care medicine. Students who perceive high technology as a panacea in clinical medicine share personal traits and attitudes toward patients that are not conducive to achieving the national goal of a 50:50 ratio between primary and non-primary care physicians.

Attitude of Health Personnel↗

PubMed2003

A self administered tool for the evaluation of the efficacy of health educational interventions in cardiac patients.

BACKGROUND: Since most cardiac rehabilitation and formal secondary prevention programmes for atherosclerotic cardiovascular disease include multidisciplinary interventions aimed at risk factors reduction and healthy lifestyle promotion, the use of specific outcome measurement instruments for the assessment of patients' knowledge before and after educational programmes should be included in usual clinical practice. For this reason we developed a new self-administered questionnaire (MaugerI CaRdiac preventiOn Questionnaire: MICRO-Q) addressed to the evaluation of information regarding secondary prevention in patients with coronary heart disease. METHODS: The development of the questionnaire consisted of different phases aimed to define the content, the number of items and the choice of possible responses. The final version of questionnaire consists of 26 items, 18 true statements and 8 false ones, with responses true, false, or don't know. MICRO-Q provides three separate scores: correct (number of items answered correctly), misconceptions (number of items wrongly answered), uncertainty (number of items answered 'don't know'), and covers knowledge of risk factors and lifestyle, diet, pre-admission avoidable delay, and cardiac disease. MICRO-Q was administered to 250 coronary patients (206 males, 44 females), mean age 61 +/- 10 years, in different geographical areas of Italy. The questionnaire's reliability was evaluated and descriptive analyses were performed. RESULTS: Spearman's Rho coefficient correlation (test-retest) for correct responses was 0.72, and the alpha value of the reliability analysis 0.68. Frequency analysis of each item was performed in detail. For the total score, the mean value was 18.90 (3.25) for the correct scale, 2.97 (1.66) for the misconceptions scale and 3.97 (3.56) for the uncertainty scale. Subgroups analysis of total scores showed no difference for gender and age, but patients with higher education had significantly higher scores on the correct scale (p < or = 0.0001), while patients with a lower level of education showed a higher score for misconceptions (p < or = 0.01). CONCLUSIONS: MICRO-Q is a simple, self-administered, efficient outcome measurement tool for the assessment of the efficacy of educational interventions in cardiac rehabilitation and secondary cardiovascular prevention. Patients' level of education and some erroneous beliefs are important keys to be taken into account in planning tailored educational interventions. In patients with coronary artery disease the MICRO-Q could be an useful and reliable clinical and quality-of-care outcome indicator for cardiac rehabilitation professionals.

Aged↗

PubMed2006

Is cumulative fossil energy demand a useful indicator for the environmental performance of products?

The appropriateness of the fossil Cumulative Energy Demand (CED) as an indicator for the environmental performance of products and processes is explored with a regression analysis between the environmental life-cycle impacts and fossil CEDs of 1218 products, divided into the product categories "energy production", "material production", "transport", and "waste treatment". Our results show that, for all product groups but waste treatment, the fossil CED correlates well with most impact categories, such as global warming, resource depletion, acidification, eutrophication, tropospheric ozone formation, ozone depletion, and human toxicity (explained variance between 46% and 100%). We conclude that the use of fossil fuels is an important driver of several environmental impacts and thereby indicative for many environmental problems. It maytherefore serve as a screening indicatorfor environmental performance. However, the usefulness of fossil CED as a stand-alone indicator for environmental impact is limited by the large uncertainty in the product-specific fossil CED-based impact scores (larger than a factor of 10 for the majority of the impact categories; 95% confidence interval). A major reason for this high uncertainty is nonfossil energy related emissions and land use, such as landfill leachates, radionuclide emissions, and land use in agriculture and forestry.

Agriculture↗

PubMed2006

Psychological distress in men with breast cancer.

PURPOSE: This article reports the first United Kingdom study to examine the prevalence of psychological distress in men with breast cancer and the factors associated with increased distress. PATIENTS AND METHODS: One hundred and sixty-one men with breast cancer completed a cross-sectional questionnaire that included measures of anxiety and depressive symptoms, cancer-specific distress, body image, coping, information and support needs, and clinical and demographic variables. RESULTS: Clinical levels of anxiety and depressive symptoms were reported by 6% and 1% of men, respectively, while 23% reported high levels of cancer-specific distress. Anxiety was most strongly associated with avoidance coping and fear and uncertainty about the future (42% of the variance in anxiety scores, P < .001). Depressive symptoms were associated with altered body image (35% of the variance, P < .001). Body image, avoidance coping, referral to the study by a clinician, fear and uncertainty, and wanting to receive more gender-specific information together explained 51% of the variance in cancer-related distress (P < .001). Clinical and demographic factors did not account for a significant proportion of the variance in any of the distress measures. CONCLUSION: Although the prevalence of clinical anxiety and depressive symptoms were low in this sample, almost a quarter of men experienced traumatic stress symptoms specific to breast cancer. Potential risk factors for distress include the use of avoidant coping strategies, negative body image, feelings of fear and uncertainty in relation to breast cancer, and unmet information needs. Suggestions are made for improving the information and support available to men with breast cancer.

Adult↗

PubMed2004

[A correlative study of the uncertainty in the climacteric women].

The purpose of this study was to explore the relationship between climacteric symptoms, knowledge, and uncertainty in climacteric women. A cross-sectional correlational research design was used. Data were collected by face-to-face interview. The Greene Climacteric Scale, Health Knowledge about Menopause Scale, and Perceived Uncertainty Scale were used to assess data. A convenience sampling approach was used to enlist 70 female subjects who were mothers of students in a nursing college located in southern Taiwan and were in perimenopause or post-menopause. The results of the study indicated that levels of uncertainty on the part of the subjects toward the climacteric state were moderate. Subjects in the perimenopause period had significantly higher levels of uncertainty about the climacteric state than those in the post-menopause period. The levels of uncertainty were significantly negatively correlated with socio-economic status. The frequency and disturbance levels of climacteric symptoms among subjects were between "not at all" and "a little". The levels of uncertainty were significantly positively correlated with frequency of and disturbance caused by the symptoms. The score on the knowledge about menopause was below average and was significantly negatively correlated with uncertainty. The degree of disturbance caused by the symptoms, menopause status, and knowledge explain 34% of the variance in uncertainty. The findings of the study support the view that climacteric women who had fewer symptoms and more knowledge had lower levels of uncertainty. Nurses can develop interventions to reduce uncertainty in climacteric women.

Climacteric↗

PubMed2000

Power comparison of parametric and nonparametric linkage tests in small pedigrees.

When the mode of inheritance of a disease is unknown, the LOD-score method of linkage analysis must take into account uncertainties in model parameters. We have previously proposed a parametric linkage test called "MFLOD," which does not require specification of disease model parameters. In the present study, we introduce two new model-free parametric linkage tests, known as "MLOD" and "MALOD." These tests are defined, respectively, as the LOD score and the admixture LOD score, maximized (subject to the same constraints as MFLOD) over disease-model parameters. We compared the power of these three parametric linkage tests and that of two nonparametric linkage tests, NPLall and NPLpairs, which are implemented in GENEHUNTER. With the use of small pedigrees and a fully informative marker, we found the powers of MLOD, NPLall, and NPLpairs to be almost equivalent to each other and not far below that of a LOD-score analysis performed under the assumption the correct genetic parameters. Thus, linkage analysis is not much hindered by uncertain mode of inheritance. The results also suggest that both parametric and nonparametric methods are suitable for linkage analysis of complex disorders in small pedigrees. However, whether these results apply to large pedigrees remains to be answered.

Chromosome Mapping↗

PubMed1996

Coping strategies and psychiatric morbidity in women attending breast assessment clinics.

This study examined the role of coping strategies and personality characteristics in mediating psychiatric morbidity in subjects facing possibly serious breast disease. Participating were 121 women aged 20 to 65 undergoing breast fine needle biopsy for a suspicious lesion on mammography. All subjects received psychosocial assessments including the 12-item General Health Questionnaire (GHQ-12), the Eysenck Personality Inventory (EPI) and the Coping Strategies Inventory. The results show that neuroticism was the only EPI subscore significantly correlated with GHQ-12 score. A habitual method of coping with adversity known as 'engagement' has a negative correlation with GHQ-12 score; that is, patients who actively confront their illness and the uncertainty that surrounds it show better psychological health. Stepwise multiple regression reveals that neuroticism and an engagement coping strategy are the most significant predictors towards GHQ-12 score prior to the diagnosis of breast cancer.

Adaptation, Psychological↗

PubMed2006

Assessment of clinical reasoning in the context of uncertainty: the effect of variability within the reference panel.

The Script Concordance Test (SCT) assesses reasoning in the context of uncertainty. Because there is no single correct answer, scoring is based on the comparison of answers provided by examinees with those provided by members of a reference panel made up of experienced practitioners. The study aimed to assess the discriminatory power of the SCT based on the variability of the reference panel's answers. Items from a bank covering different family medicine domains were classified into 3 groups according to the degree of variability of answers provided by a pool of experienced doctors. A variability index (mean squared error) was used to select items in the low, moderate and high variability categories. A 102-item test (Cronbach's alpha 0.70), made up of 3 subtests of each category, was administered to 3 contrasting groups in family medicine: 157 clerkship students, 30 residents and 30 practising doctors. anova and effect size (ES) were used to quantify and test the discrimination power of the 3 subtests. The high variability subtest showed high effect size for discrimination between extreme groups (ES = 1.5; F = 16.3, P < 0.001), whereas the moderate variability subtest showed less effect size (ES = 0.56; F = 57, P = 0.041). The low variability subtest did not discriminate significantly (ES = 0.31; F = 2.9, P = 0.06). Variability of answers within the reference panel is a key component of the discriminatory power of the SCT. In accordance with theory, the presence of variability ensures discrimination between levels of clinical experience. These results imply important considerations for the construction of efficient SCTs.

Analysis of Variance↗

PubMed2002

Anatomical variability of the anterior cingulate gyrus and basic dimensions of human personality.

This study focused on investigating a possible relationship between interindividual variability in the morphology of the cingulate gyrus and behavioral styles. Using magnetic resonance images obtained from 100 healthy young volunteers (50 women and 50 men), we measured the surface area of the anterior cingulate gyrus and related it to the scores on the Temperament and Character Inventory. Anatomical data revealed that hemispheric asymmetry in the anterior cingulate gyrus surface area was very common (83% of cases) and that a prominent right anterior cingulate was more frequent in women than in men. In the correlational analysis, surface measurements of the right anterior cingulate gyrus accounted for a 24% score variance in Harm Avoidance. Both women and men with larger right anterior cingulate described themselves as experiencing greater worry about possible problems, fearfulness in the face of uncertainty, shyness with strangers, and fatigability. Furthermore, women reported overall higher scores in Harm Avoidance than men; these gender differences were largely explained by gender differences in the right anterior cingulate area in a covariate analysis. Our observations suggest that a large right anterior cingulate is related to a temperamental disposition to fear and anticipatory worry in both genders and that a higher prevalence of these traits in women may be coupled with a greater expansion of this brain region.

Adult↗

PubMed2003

Understanding adolescent worry: the application of a cognitive model.

The relationship between worry and 4 cognitive variables, intolerance of uncertainty, positive beliefs about worry, negative problem orientation, and cognitive avoidance, was examined in an adolescent sample of 528 boys and girls aged 14-18. The participants completed questionnaires assessing worry, somatic anxiety symptoms, and the variables mentioned above. The results show that (a) intolerance of uncertainty, positive beliefs about worry, and negative problem orientation each account for a significant amount of variance in adolescent worry scores in the multiple regression, and (b) the discriminant function derived from the 4 variables is effective in classifying moderate and high worriers into their respective groups (72.8% correct classification). Furthermore, analyses demonstrate that intolerance of uncertainty has the strongest association with worry scores and is the most important variable in discriminating between moderate and high adolescent worriers. These results suggest that intolerance of uncertainty plays a key role in our understanding of adolescent worry.

Adaptation, Psychological↗

PubMed2006

An intuitive visualisation of intercomparison results applied to the KCDB.

A simple and intuitive graphical method is presented for producing a summary overview of experimental results of a common measurand, e.g. in the frame of an intercomparison. The PomPlots display (relative) deviations of individual results from the consensus value on the horizontal axis and (relative) uncertainties on the vertical axis. The z-scores, z=1, 2 and 3, are represented by diagonal lines, creating the aspect of a pyramidal structure. The most accurate and precise measurement results should be situated close to the top of the pyramid. The plots are used to visualise data from the BIPM key comparison database on primary radioactivity measurements.

Algorithms↗

PubMed2006

The ties problem resulting from counting-based error estimators and its impact on gene selection algorithms.

MOTIVATION: Feature selection approaches, such as filter and wrapper, have been applied to address the gene selection problem in the literature of microarray data analysis. In wrapper methods, the classification error is usually used as the evaluation criterion of feature subsets. Due to the nature of high dimensionality and small sample size of microarray data, however, counting-based error estimation may not necessarily be an ideal criterion for gene selection problem. RESULTS: Our study reveals that evaluating genes in terms of counting-based error estimators such as resubstitution error, leave-one-out error, cross-validation error and bootstrap error may encounter severe ties problem, i.e. two or more gene subsets score equally, and this in turn results in uncertainty in gene selection. Our analysis finds that the ties problem is caused by the discrete nature of counting-based error estimators and could be avoided by using continuous evaluation criteria instead. Experiment results show that continuous evaluation criteria such as generalised the absolute value of w2 measure for support vector machines and modified Relief's measure for k-nearest neighbors produce improved gene selection compared with counting-based error estimators. AVAILABILITY: The companion website is at http://www.ntu.edu.sg/home5/pg02776030/wrappers/ The website contains (1) the source code of all the gene selection algorithms and (2) the complete set of tables and figures of experiments.

Algorithms↗

PubMed2005

Assessment in the context of uncertainty: how many members are needed on the panel of reference of a script concordance test?

PURPOSE: The script concordance test (SCT) assesses clinical reasoning in the context of uncertainty. Because there is no single correct answer, scoring is based on a comparison of answers provided by examinees with those provided by members of a panel of reference made up of experienced practitioners. This study aims to determine how many members are needed on the panel to obtain reliable scores to compare against the scores of examinees. METHODS: A group of 80 residents were tested on 73 items (Cronbach's alpha: 0.76). A total of 38 family doctors made up the pool of experienced practitioners, from which 1000 random panels of reference of increasing sizes (5, 10, 15, 20, 25 and 30) were generated with a resampling procedure. Residents' scores were computed for each panel sample. Units of analysis were means of residents' score, test reliability coefficient and correlation coefficient between scores obtained with a given panel of reference versus the scores obtained with the full panel of 38. Statistics were averaged across the 1000 samples for each panel size for the mean and test reliability computations, and across 100 samples for the correlation computation. RESULTS: For sample variability, there was a 3-fold increase in standard deviation of means between a sample panel size of 5 (SD=1.57) and a panel size of 30 (SD=0.50). For reliability, there was a large difference in precision between a panel size of 5 (0.62) and a panel size of 10 (0.70). When the panel size was over 20, the gain became negligible (0.74 for 20 and 0.76 for 38). For correlation, the mean correlation coefficient values were 0.90 with 5 panel members, 0.95 with 10 members and 0.98 with 20 members. CONCLUSION: Any number over 10 is associated with acceptable reliability and good correlation between the samples versus the full panel of 38. For high stake examinations, using a panel of 20 members is recommended. Recruiting more than 20 panel members shows only a marginal benefit in terms of psychometric properties.

Adult↗

PubMed1994

Comparison of two indices of dental fluorosis in low, moderate and high fluorosis Tanzanian populations.

This study aimed at comparing the Thylstrup-Fejerskov index (TFI) and the Dean's Index (DI) which were applied on three communities with different severity of dental fluorosis. A total of 1565 children aged between 11 and 18 yr with a mean age of 14.7 were examined for dental fluorosis with the TFI and 1155 of these children were also examined with the DI. The measurement error for the TFI was 0.50 (10 scale point) compared to 0.53 for DI (6 scale point). The Kappa values and the measurement-remeasurement correlation appeared to be better for the TFI. No difficulties were encountered in applying the TFI in contrast to the DI, which caused uncertainties in assessing the "questionable" and "very mild" scores, and this may explain the relatively better reproducibility of the TFI. The correspondence between both indices was determined. TFI 0 corresponded well with DI 0. The conversion values for TFI 1, 2, 3 and 4 into DI scores were 0.3, 0.8, 1.4 and 2.4 respectively. The TFI 5-9 corresponded with DI score 4. TFI could discriminate the severe forms of dental fluorosis which were categorized in Dean's highest score 4. TFI was able to reveal more dental fluorosis than DI in communities with minor and moderate dental fluorosis. In the community with severe dental fluorosis where more than 85% of all teeth exhibited a DI > or = 1, both indices revealed a comparable prevalence of dental fluorosis. The TFI is considered a near ideal instrument.

Adolescent↗

PubMed2006

Quantification of the variation in percentage identity for protein sequence alignments.

BACKGROUND: Percentage Identity (PID) is frequently quoted in discussion of sequence alignments since it appears simple and easy to understand. However, although there are several different ways to calculate percentage identity and each may yield a different result for the same alignment, the method of calculation is rarely reported. Accordingly, quantification of the variation in PID caused by the different calculations would help in interpreting PID values in the literature. In this study, the variation in PID was quantified systematically on a reference set of 1028 alignments generated by comparison of the protein three-dimensional structures. Since the alignment algorithm may also affect the range of PID, this study also considered the effect of algorithm, and the combination of algorithm and PID method. RESULTS: The maximum variation in PID due to the calculation method was 11.5% while the effect of alignment algorithm on PID was up to 14.6% across three popular alignment methods. The combined effect of alignment algorithm and PID calculation gave a variation of up to 22% on the test data, with an average of 5.3% +/- 2.8% for sequence pairs with < 30% identity. In order to see which PID method was most highly correlated with structural similarity, four different PID calculations were compared to similarity scores (Sc) from the comparison of the corresponding protein three-dimensional structures. The highest correlation coefficient for a PID calculation was 0.80. In contrast, the more sophisticated Z-score calculated by reference to randomized sequences gave a correlation coefficient of 0.84. CONCLUSION: Although it is well known amongst expert sequence analysts that PID is a poor score for discriminating between protein sequences, the apparent simplicity of the percentage identity score encourages its widespread use in establishing cutoffs for structural similarity. This paper illustrates that not only is PID a poor measure of sequence similarity when compared to the Z-score, but that there is also a large uncertainty in reported PID values. Since better alternatives to PID exist to quantify sequence similarity, these should be quoted where possible in preference to PID. The findings presented here should prove helpful to those new to sequence analysis, and in warning those who seek to interpret the value of a PID reported in the literature.

Algorithms↗